Lineage for Protein: Dihydrofolate reductase, prokaryotic type

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 707730Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 707731Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) (S)
  5. 707732Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 707752Protein Dihydrofolate reductase, prokaryotic type [53599] (6 species)

Species:

  1. 707753Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
  2. 707755Escherichia coli [TaxId:562] [53600] (45 PDB entries)
    1. Domains for 1ddr:
      1. 707785Domain d1ddra_: 1ddr A: [34856]
      2. 707786Domain d1ddrb_: 1ddr B: [34857]
        complexed with ca, cl, mtx, ure
    2. Domains for 1dds:
      1. 707788Domain d1ddsa_: 1dds A: [34858]
      2. 707789Domain d1ddsb_: 1dds B: [34859]
        complexed with ca, cl, mtx
    3. Domains for 1dhi:
      1. 707772Domain d1dhia_: 1dhi A: [34844]
      2. 707773Domain d1dhib_: 1dhi B: [34845]
        complexed with ca, cl, mtx; mutant
    4. Domains for 1dhj:
      1. 707764Domain d1dhja_: 1dhj A: [34833]
      2. 707765Domain d1dhjb_: 1dhj B: [34834]
        complexed with ca, cl, mtx; mutant
    5. Domains for 1dra:
      1. 707760Domain d1draa_: 1dra A: [34831]
      2. 707761Domain d1drab_: 1dra B: [34832]
        complexed with ca, cl, mtx; mutant
    6. Domains for 1drb:
      1. 707762Domain d1drba_: 1drb A: [34828]
      2. 707763Domain d1drbb_: 1drb B: [34829]
        complexed with ca, cl, eoh, mtx; mutant
    7. Domain for 1dre:
    8. Domain for 1drh:
    9. Domains for 1dyh:
      1. 707774Domain d1dyha_: 1dyh A: [34842]
      2. 707775Domain d1dyhb_: 1dyh B: [34843]
        complexed with ca, cl, dzf
    10. Domains for 1dyi:
      1. 707766Domain d1dyia_: 1dyi A: [34837]
      2. 707767Domain d1dyib_: 1dyi B: [34838]
        complexed with ca, cl, fol
    11. Domains for 1dyj:
      1. 707768Domain d1dyja_: 1dyj A: [34826]
      2. 707769Domain d1dyjb_: 1dyj B: [34827]
        complexed with ca, cl, ddf
    12. Domains for 1jol:
      1. 707779Domain d1jola_: 1jol A: [34846]
      2. 707780Domain d1jolb_: 1jol B: [34847]
        complexed with ca, cl, ffo
    13. Domain for 1jom:
    14. Domain for 1ra1:
    15. Domain for 1ra2:
    16. Domain for 1ra3:
    17. Domain for 1ra8:
    18. Domain for 1ra9:
    19. Domains for 1rb2:
      1. 707806Domain d1rb2a_: 1rb2 A: [34863]
      2. 707807Domain d1rb2b_: 1rb2 B: [34864]
        complexed with fol, nap
    20. Domains for 1rb3:
      1. 707809Domain d1rb3a_: 1rb3 A: [34861]
      2. 707810Domain d1rb3b_: 1rb3 B: [34862]
        complexed with mtx, nap
    21. Domain for 1rc4:
    22. Domains for 1rd7:
      1. 707799Domain d1rd7a_: 1rd7 A: [34871]
      2. 707800Domain d1rd7b_: 1rd7 B: [34872]
        complexed with bme, fol
    23. Domains for 1re7:
      1. 707804Domain d1re7a_: 1re7 A: [34875]
      2. 707805Domain d1re7b_: 1re7 B: [34876]
        complexed with fol
    24. Domain for 1rf7:
    25. Domain for 1rg7:
    26. Domain for 1rh3:
    27. Domain for 1rx1:
    28. Domain for 1rx2:
    29. Domain for 1rx3:
    30. Domain for 1rx4:
    31. Domain for 1rx5:
    32. Domain for 1rx6:
    33. Domain for 1rx7:
    34. Domain for 1rx8:
    35. Domain for 1rx9:
    36. Domains for 1tdr:
      1. 707791Domain d1tdra_: 1tdr A: [34865]
      2. 707792Domain d1tdrb_: 1tdr B: [34866]
        complexed with ca, cl, mtx, te
    37. Domain for 2ano:
    38. Domain for 2anq:
    39. Domains for 2drc:
      1. 707781Domain d2drca_: 2drc A: [34848]
      2. 707782Domain d2drcb_: 2drc B: [34849]
        complexed with ca, cl, mtx; mutant
    40. Domains for 2inq:
      1. 707812Domain d2inqa1: 2inq A:1-159 [137531]
        automatically matched to d1dre__
        complexed with mt1; mutant
      2. 707813Domain d2inqb1: 2inq B:1-159 [137532]
        automatically matched to d1dre__
        complexed with mt1; mutant
    41. Domains for 3drc:
      1. 707777Domain d3drca_: 3drc A: [34840]
      2. 707778Domain d3drcb_: 3drc B: [34841]
        complexed with ca, cl, mtx
    42. Domains for 4dfr:
      1. 707757Domain d4dfra_: 4dfr A: [34822]
      2. 707758Domain d4dfrb_: 4dfr B: [34823]
        complexed with ca, cl, mtx
    43. Domain for 5dfr:
    44. Domain for 6dfr:
    45. Domain for 7dfr:
  3. 707820Haloferax volcanii [TaxId:2246] [53604] (1 PDB entry)
  4. 707823Lactobacillus casei [TaxId:1582] [53601] (8 PDB entries)
    1. Domain for 1ao8:
    2. Domain for 1bzf:
    3. Domain for 1dis:
    4. Domain for 1diu:
    5. Domain for 1lud:
    6. Domain for 2hm9:
    7. Domain for 2hqp:
    8. Domain for 3dfr:
  5. 707832Mycobacterium tuberculosis [TaxId:1773] [53602] (4 PDB entries)
    1. Domain for 1df7:
    2. Domain for 1dg5:
    3. Domain for 1dg7:
    4. Domain for 1dg8:
  6. 707837Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
    1. Domains for 1cz3:
      1. 707838Domain d1cz3a_: 1cz3 A: [34891]
      2. 707839Domain d1cz3b_: 1cz3 B: [34892]
        complexed with so4
    2. Domains for 1d1g:
      1. 707840Domain d1d1ga_: 1d1g A: [34889]
      2. 707841Domain d1d1gb_: 1d1g B: [34890]
        complexed with mtx, ndp

More info for Protein Dihydrofolate reductase, prokaryotic type from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Dihydrofolate reductase, prokaryotic type from c.71.1.1: Dihydrofolate reductases: