Lineage for Family c.71.1.1: Dihydrofolate reductases

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2153715Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2153716Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2153717Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

Proteins:

  1. 2153718Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)
    1. 2153719Species Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries)
      Uniprot Q5CGA3 Q27552
    2. 2153735Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
  2. 2153746Dihydrofolate reductase, prokaryotic type [53599] (8 species)
    1. 2153747Species Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
    2. 2153749Species Escherichia coli K-12 [TaxId:83333] [187149] (6 PDB entries)
    3. 2153757Species Escherichia coli [TaxId:562] [53600] (79 PDB entries)
    4. 2153863Species Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)
    5. 2153868Species Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)
    6. 2153879Species Mycobacterium tuberculosis [TaxId:1773] [53602] (6 PDB entries)
    7. 2153889Species Staphylococcus aureus [TaxId:1280] [188976] (25 PDB entries)
    8. 2153915Species Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
  3. 2153920Dihydrofolate reductases, eukaryotic type [53605] (7 species)
    1. 2153921Species Candida glabrata [TaxId:284593] [237803] (4 PDB entries)
    2. 2153930Species Candida glabrata [TaxId:5478] [188672] (1 PDB entry)
    3. 2153933Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)
    4. 2153942Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)
    5. 2153968Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
    6. 2154054Species Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)
    7. 2154061Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
  4. 2154096automated matches [190514] (11 species)
    not a true protein
    1. 2154097Species Escherichia coli [TaxId:562] [187587] (3 PDB entries)
    2. 2154102Species Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)
    3. 2154105Species Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)
    4. 2154111Species Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)
    5. 2154114Species Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)
    6. 2154117Species Mycobacterium tuberculosis [TaxId:83332] [329359] (1 PDB entry)
    7. 2154119Species Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)
    8. 2154124Species Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)
    9. 2154126Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)
    10. 2154135Species Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)
    11. 2154137Species Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases: