Lineage for Protein: Acetylcholinesterase

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2474355Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
  4. 2474356Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families) (S)
    many members have left-handed crossover connection between strand 8 and additional strand 9
  5. 2474357Family c.69.1.1: Acetylcholinesterase-like [53475] (6 protein domains)
    automatically mapped to Pfam PF00135
  6. 2474358Protein Acetylcholinesterase [53476] (6 species)

Species:

  1. 2474359Electric eel (Electrophorus electricus) [TaxId:8005] [53478] (3 PDB entries)
    1. Domain for 1c2b:
    2. Domains for 1c2o:
      1. 2474361Domain d1c2oa_: 1c2o A: [34610]
      2. 2474362Domain d1c2ob_: 1c2o B: [34611]
      3. 2474363Domain d1c2oc_: 1c2o C: [34612]
      4. 2474364Domain d1c2od_: 1c2o D: [34613]
    3. Domain for 1eea:
  2. 2474366Fruit fly (Drosophila melanogaster) [TaxId:7227] [53481] (3 PDB entries)
    1. Domain for 1dx4:
    2. Domain for 1qo9:
    3. Domain for 1qon:
  3. 2474370Human (Homo sapiens) [TaxId:9606] [53480] (16 PDB entries)
    1. Domain for 1b41:
    2. Domain for 1f8u:
    3. Domains for 4ey4:
      1. 2474377Domain d4ey4a_: 4ey4 A: [194513]
        automated match to d1maac_
        complexed with edo, fuc, nag, no3, pe8
      2. 2474378Domain d4ey4b_: 4ey4 B: [194514]
        automated match to d1maac_
        complexed with edo, fuc, nag, no3, pe8
    4. Domains for 4ey5:
      1. 2474385Domain d4ey5a_: 4ey5 A: [194518]
        automated match to d1maac_
        complexed with dms, edo, fuc, hup, nag, no3
      2. 2474386Domain d4ey5b_: 4ey5 B: [194517]
        automated match to d1maac_
        complexed with dms, edo, fuc, hup, nag, no3
    5. Domains for 4ey6:
      1. 2474391Domain d4ey6a_: 4ey6 A: [194511]
        automated match to d1maac_
        complexed with edo, fuc, gnt, nag, no3, pe8
      2. 2474392Domain d4ey6b_: 4ey6 B: [194510]
        automated match to d1maac_
        complexed with edo, fuc, gnt, nag, no3, pe8
    6. Domains for 4ey7:
      1. 2474389Domain d4ey7a_: 4ey7 A: [194515]
        automated match to d1maac_
        complexed with e20, edo, fuc, nag, no3
      2. 2474390Domain d4ey7b_: 4ey7 B: [194516]
        automated match to d1maac_
        complexed with e20, edo, fuc, nag, no3
    7. Domain for 4ey8:
    8. Domains for 4m0e:
      1. 2474371Domain d4m0ea_: 4m0e A: [228381]
        automated match to d4ey6b_
        complexed with 1yl, edo, nag, no3
      2. 2474372Domain d4m0eb_: 4m0e B: [228383]
        automated match to d4ey6b_
        complexed with 1yl, edo, nag, no3
    9. Domains for 4m0f:
      1. 2474373Domain d4m0fa_: 4m0f A: [228384]
        automated match to d4ey6b_
        complexed with 1yk, edo, nag, no3
      2. 2474374Domain d4m0fb_: 4m0f B: [228385]
        automated match to d4ey6b_
        complexed with 1yk, edo, nag, no3
    10. Domain for 4pqe:
    11. Domains for 5hf5:
      1. 2474375Domain d5hf5a_: 5hf5 A: [320058]
        automated match to d2xupa_
        complexed with dep, edo, fuc, nag, no3, pe8
      2. 2474376Domain d5hf5b_: 5hf5 B: [320120]
        automated match to d2xupa_
        complexed with dep, edo, fuc, nag, no3, pe8
    12. Domains for 5hf6:
      1. 2474387Domain d5hf6a_: 5hf6 A: [318768]
        automated match to d2xupa_
        complexed with edo, efs, fuc, nag
      2. 2474388Domain d5hf6b_: 5hf6 B: [318762]
        automated match to d2xupa_
        complexed with edo, efs, fuc, nag
    13. Domains for 5hf8:
      1. 2474396Domain d5hf8a_: 5hf8 A: [318867]
        automated match to d2xupa_
        complexed with dep, edo, efs, fuc, nag, no3
      2. 2474397Domain d5hf8b_: 5hf8 B: [318864]
        automated match to d2xupa_
        complexed with dep, edo, efs, fuc, nag, no3
    14. Domains for 5hf9:
      1. 2474382Domain d5hf9a_: 5hf9 A: [318767]
        automated match to d2xupa_
        complexed with dep, edo, fuc, hi6, nag, no3, pe8
      2. 2474383Domain d5hf9b_: 5hf9 B: [318863]
        automated match to d2xupa_
        complexed with dep, edo, fuc, hi6, nag, no3, pe8
    15. Domains for 5hfa:
      1. 2474380Domain d5hfaa_: 5hfa A: [318746]
        automated match to d2xupa_
        complexed with dep, edo, fp1, fuc, nag, no3
      2. 2474381Domain d5hfab_: 5hfa B: [318825]
        automated match to d2xupa_
        complexed with dep, edo, fp1, fuc, nag, no3
    16. Domains for 5hq3:
      1. 2474393Domain d5hq3a_: 5hq3 A: [320078]
        automated match to d1maac_
        complexed with mes, vx
      2. 2474394Domain d5hq3b_: 5hq3 B: [320086]
        automated match to d1maac_
        complexed with mes, vx
  4. 2474399Mouse (Mus musculus) [TaxId:10090] [53479] (30 PDB entries)
    1. Domains for 1j06:
      1. 2474408Domain d1j06a_: 1j06 A: [77021]
        complexed with ae3, co3, nag, p6g, pg4
      2. 2474409Domain d1j06b_: 1j06 B: [77022]
        complexed with ae3, co3, nag, p6g, pg4
    2. Domains for 1j07:
      1. 2474402Domain d1j07a_: 1j07 A: [77023]
        complexed with cl, co3, dcu, nag, p6g, pg4
      2. 2474403Domain d1j07b_: 1j07 B: [77024]
        complexed with cl, co3, dcu, nag, p6g, pg4
    3. Domain for 1ku6:
    4. Domains for 1maa:
      1. 2474433Domain d1maaa_: 1maa A: [34615]
        complexed with dme, gol, nag, po4
      2. 2474434Domain d1maab_: 1maa B: [34616]
        complexed with dme, gol, nag, po4
      3. 2474435Domain d1maac_: 1maa C: [34617]
        complexed with dme, gol, nag, po4
      4. 2474436Domain d1maad_: 1maa D: [34618]
        complexed with dme, gol, nag, po4
    5. Domain for 1mah:
    6. Domains for 1n5m:
      1. 2474416Domain d1n5ma_: 1n5m A: [80031]
        complexed with co3, gmn, iod, nag, p6g, pg4
      2. 2474417Domain d1n5mb_: 1n5m B: [80032]
        complexed with co3, gmn, iod, nag, p6g, pg4
    7. Domains for 1n5r:
      1. 2474422Domain d1n5ra_: 1n5r A: [80037]
        complexed with acy, nag, p6g, pg4, prm
      2. 2474423Domain d1n5rb_: 1n5r B: [80038]
        complexed with acy, nag, p6g, pg4, prm
    8. Domains for 1q83:
      1. 2474414Domain d1q83a_: 1q83 A: [96154]
        complexed with nag, p6g, tz5
      2. 2474415Domain d1q83b_: 1q83 B: [96155]
        complexed with nag, p6g, tz5
    9. Domains for 1q84:
      1. 2474404Domain d1q84a_: 1q84 A: [96156]
        complexed with nag, p6g, tz4
      2. 2474405Domain d1q84b_: 1q84 B: [96157]
        complexed with nag, p6g, tz4
    10. Domains for 2gyu:
      1. 2474400Domain d2gyua_: 2gyu A: [135873]
        automated match to d1maac_
        complexed with hi6, nag, p4g, p6g
      2. 2474401Domain d2gyub_: 2gyu B: [135874]
        automated match to d1maac_
        complexed with hi6, nag, p4g, p6g
    11. Domains for 2gyv:
      1. 2474420Domain d2gyva_: 2gyv A: [135875]
        automated match to d1maac_
        complexed with co3, hbp, nag, p3g
      2. 2474421Domain d2gyvb_: 2gyv B: [135876]
        automated match to d1maac_
        complexed with co3, hbp, nag, p3g
    12. Domains for 2gyw:
      1. 2474406Domain d2gywa_: 2gyw A: [135877]
        automated match to d1maac_
        complexed with co3, nag, obi, p6g
      2. 2474407Domain d2gywb_: 2gyw B: [135878]
        automated match to d1maac_
        complexed with co3, nag, obi, p6g
    13. Domains for 3dl4:
      1. 2474412Domain d3dl4a_: 3dl4 A: [174045]
        automated match to d1maac_
        complexed with p6g
      2. 2474413Domain d3dl4b_: 3dl4 B: [174046]
        automated match to d1maac_
        complexed with p6g
    14. Domains for 3dl7:
      1. 2474410Domain d3dl7a_: 3dl7 A: [174047]
        Other proteins in same PDB: d3dl7b2
        automated match to d1maac_
        complexed with cl, nag, p6g, pg4
      2. 2474411Domain d3dl7b1: 3dl7 B:4-543 [174048]
        Other proteins in same PDB: d3dl7b2
        automated match to d1maac_
        complexed with cl, nag, p6g, pg4
    15. Domains for 3zlv:
      1. 2474452Domain d3zlva_: 3zlv A: [192674]
        automated match to d1maac_
        complexed with 1ka, co3, hi6, pe4
      2. 2474453Domain d3zlvb_: 3zlv B: [192912]
        automated match to d1maac_
        complexed with 1ka, co3, hi6, pe4
    16. Domains for 4bc1:
      1. 2474429Domain d4bc1a_: 4bc1 A: [192858]
        automated match to d1maac_
        complexed with cl, nag, so4, tqv
      2. 2474430Domain d4bc1b_: 4bc1 B: [192856]
        automated match to d1maac_
        complexed with cl, nag, so4, tqv
      3. 2474431Domain d4bc1c_: 4bc1 C: [192619]
        automated match to d1maac_
        complexed with cl, nag, so4, tqv
      4. 2474432Domain d4bc1d_: 4bc1 D: [192857]
        automated match to d1maac_
        complexed with cl, nag, so4, tqv
    17. Domains for 4btl:
      1. 2474427Domain d4btla_: 4btl A: [227837]
        automated match to d1n5ra_
        complexed with 5gz, edo, nag, pe3
      2. 2474428Domain d4btlb_: 4btl B: [227836]
        automated match to d1n5rb_
        complexed with 5gz, edo, nag, pe3
    18. Domains for 5dti:
      1. 2474418Domain d5dtia1: 5dti A:1-542 [278353]
        Other proteins in same PDB: d5dtia2
        automated match to d2whqa_
      2. 2474419Domain d5dtib_: 5dti B: [278356]
        Other proteins in same PDB: d5dtia2
        automated match to d2whqa_
    19. Domains for 5dtj:
      1. 2474460Domain d5dtja1: 5dtj A:1-540 [278357]
        Other proteins in same PDB: d5dtja2
        automated match to d2whqa_
        complexed with 5g8
      2. 2474461Domain d5dtjb_: 5dtj B: [278355]
        Other proteins in same PDB: d5dtja2
        automated match to d2whqa_
        complexed with 5g8
    20. Domains for 5ehn:
      1. 2474454Domain d5ehna_: 5ehn A: [313718]
        automated match to d1j07a_
        complexed with 5nz, nag, p6g
      2. 2474455Domain d5ehnb_: 5ehn B: [313719]
        automated match to d1j07a_
        complexed with 5nz, nag, p6g
    21. Domains for 5ehq:
      1. 2474450Domain d5ehqa_: 5ehq A: [313803]
        automated match to d1j07a_
        complexed with 5o2, fuc, nag, p6g
      2. 2474451Domain d5ehqb_: 5ehq B: [313770]
        automated match to d1j07a_
        complexed with 5o2, fuc, nag, p6g
    22. Domains for 5ehz:
      1. 2474446Domain d5ehza_: 5ehz A: [313701]
        automated match to d1j07a_
        complexed with 5nz, nag, p6g
      2. 2474447Domain d5ehzb_: 5ehz B: [313797]
        automated match to d1j07b_
        complexed with 5nz, nag, p6g
    23. Domains for 5eia:
      1. 2474458Domain d5eiaa_: 5eia A: [313750]
        automated match to d1j07a_
        complexed with 5o2, nag, pg4
      2. 2474459Domain d5eiab_: 5eia B: [313812]
        automated match to d1j07b_
        complexed with 5o2, nag, pg4
    24. Domains for 5eie:
      1. 2474425Domain d5eiea_: 5eie A: [313894]
        automated match to d1j07a_
        complexed with 7pg, act, cl, fuc, nag, pg4, tz2
      2. 2474426Domain d5eieb_: 5eie B: [313645]
        automated match to d1j07a_
        complexed with 7pg, act, cl, fuc, nag, pg4, tz2
    25. Domains for 5eih:
      1. 2474456Domain d5eiha_: 5eih A: [313681]
        automated match to d1j07a_
        complexed with act, p6g, pz5, tz2
      2. 2474457Domain d5eihb_: 5eih B: [313665]
        automated match to d1j07b_
        complexed with act, p6g, pz5, tz2
    26. Domains for 5foq:
      1. 2474437Domain d5foqa_: 5foq A: [314462]
        automated match to d1maac_
        complexed with gc8, nag, p15, pg0
      2. 2474438Domain d5foqb_: 5foq B: [314469]
        automated match to d1maac_
        complexed with gc8, nag, p15, pg0
    27. Domains for 5fpp:
      1. 2474440Domain d5fppa1: 5fpp A:1-543 [317235]
        Other proteins in same PDB: d5fppa2, d5fppb2
        automated match to d1maac_
        complexed with ae3, co3, hi6, nag, p6g
      2. 2474441Domain d5fppb1: 5fpp B:5-543 [317257]
        Other proteins in same PDB: d5fppa2, d5fppb2
        automated match to d1maac_
        complexed with ae3, co3, hi6, nag, p6g
    28. Domains for 5fum:
      1. 2474448Domain d5fuma_: 5fum A: [322936]
        automated match to d1maac_
        complexed with pe4, pg0, sof
      2. 2474449Domain d5fumb_: 5fum B: [322944]
        automated match to d1maac_
        complexed with pe4, pg0, sof
    29. Domains for 5hcu:
      1. 2474444Domain d5hcua1: 5hcu A:1-540 [314894]
        Other proteins in same PDB: d5hcua2
        automated match to d2whqa_
      2. 2474445Domain d5hcub_: 5hcu B: [314650]
        Other proteins in same PDB: d5hcua2
        automated match to d2whqa_
    30. Domains for 5ov9:
      1. 2474442Domain d5ov9a_: 5ov9 A: [338607]
        automated match to d1maac_
        complexed with ae3, cvi, edo, etx, nag, pe4, peg, pg0, pge
      2. 2474443Domain d5ov9b_: 5ov9 B: [338611]
        automated match to d1maac_
        complexed with ae3, cvi, edo, etx, nag, pe4, peg, pg0, pge
  5. 2474462Pacific electric ray (Torpedo californica) [TaxId:7787] [53477] (91 PDB entries)
    Uniprot P04058 25-556
    1. Domain for 1acj:
    2. Domain for 1acl:
    3. Domain for 1amn:
    4. Domain for 1ax9:
    5. Domain for 1cfj:
    6. Domain for 1dx6:
    7. Domain for 1e3q:
    8. Domain for 1e66:
    9. Domain for 1ea5:
    10. Domain for 1eve:
    11. Domain for 1fss:
    12. Domain for 1gpk:
    13. Domain for 1gpn:
    14. Domain for 1gqr:
    15. Domain for 1gqs:
    16. Domain for 1h22:
    17. Domain for 1h23:
    18. Domain for 1hbj:
    19. Domain for 1jjb:
    20. Domain for 1oce:
    21. Domain for 1odc:
    22. Domain for 1qid:
    23. Domain for 1qie:
    24. Domain for 1qif:
    25. Domain for 1qig:
    26. Domain for 1qih:
    27. Domain for 1qii:
    28. Domain for 1qij:
    29. Domain for 1qik:
    30. Domain for 1qim:
    31. Domain for 1qti:
    32. Domain for 1som:
    33. Domain for 1u65:
    34. Domain for 1vot:
    35. Domain for 1vxo:
    36. Domain for 1vxr:
    37. Domain for 1w4l:
    38. Domain for 1w6r:
    39. Domains for 1w75:
      1. 2474506Domain d1w75a_: 1w75 A: [114313]
        complexed with nag
      2. 2474507Domain d1w75b_: 1w75 B: [114314]
        complexed with nag
    40. Domains for 1w76:
      1. 2474512Domain d1w76a_: 1w76 A: [114315]
        complexed with gnt, nag
      2. 2474513Domain d1w76b_: 1w76 B: [114316]
        complexed with gnt, nag
    41. Domain for 1zgb:
    42. Domains for 1zgc:
      1. 2474477Domain d1zgca_: 1zgc A: [125024]
        automated match to d1eve__
        complexed with a2e, nag
      2. 2474478Domain d1zgcb_: 1zgc B: [125025]
        automated match to d1eve__
        complexed with a2e, nag
    43. Domain for 2ace:
    44. Domain for 2ack:
    45. Domain for 2bag:
    46. Domain for 2c4h:
    47. Domain for 2c58:
    48. Domain for 2c5f:
    49. Domain for 2c5g:
    50. Domain for 2cek:
    51. Domain for 2ckm:
    52. Domain for 2cmf:
    53. Domain for 2dfp:
    54. Domain for 2j3d:
    55. Domain for 2j3q:
    56. Domain for 2j4f:
    57. Domains for 2v96:
      1. 2474509Domain d2v96a_: 2v96 A: [152797]
        automated match to d1evea_
        complexed with cfq, nag
      2. 2474510Domain d2v96b_: 2v96 B: [152798]
        automated match to d1evea_
        complexed with cfq, nag
    58. Domains for 2v97:
      1. 2474533Domain d2v97a_: 2v97 A: [152799]
        automated match to d1evea_
        complexed with cfq, cl, nag
      2. 2474534Domain d2v97b_: 2v97 B: [152800]
        automated match to d1evea_
        complexed with cfq, cl, nag
    59. Domains for 2va9:
      1. 2474497Domain d2va9a_: 2va9 A: [152824]
        automated match to d1evea_
        complexed with nag
      2. 2474498Domain d2va9b_: 2va9 B: [152825]
        automated match to d1evea_
        complexed with nag
    60. Domain for 2vb4:
    61. Domains for 2vja:
      1. 2474483Domain d2vjaa_: 2vja A: [153186]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
      2. 2474484Domain d2vjab_: 2vja B: [153187]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
    62. Domains for 2vjb:
      1. 2474490Domain d2vjba_: 2vjb A: [153188]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
      2. 2474491Domain d2vjbb_: 2vjb B: [153189]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
    63. Domains for 2vjc:
      1. 2474475Domain d2vjca_: 2vjc A: [153190]
        automated match to d1evea_
        complexed with ccd, chh, cl, nag, pge
      2. 2474476Domain d2vjcb_: 2vjc B: [153191]
        automated match to d1evea_
        complexed with ccd, chh, cl, nag, pge
    64. Domains for 2vjd:
      1. 2474486Domain d2vjda_: 2vjd A: [153192]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
      2. 2474487Domain d2vjdb_: 2vjd B: [153193]
        automated match to d1evea_
        complexed with ccd, cl, nag, pge
    65. Domain for 2vq6:
    66. Domains for 2vt6:
      1. 2474499Domain d2vt6a_: 2vt6 A: [153538]
        automated match to d1evea_
        complexed with cl, nag, pge
      2. 2474500Domain d2vt6b_: 2vt6 B: [153539]
        automated match to d1evea_
        complexed with cl, nag, pge
    67. Domains for 2vt7:
      1. 2474529Domain d2vt7a_: 2vt7 A: [153540]
        automated match to d1evea_
        complexed with cl, nag, pge
      2. 2474530Domain d2vt7b_: 2vt7 B: [153541]
        automated match to d1evea_
        complexed with cl, nag, pge
    68. Domain for 2wfz:
    69. Domain for 2wg0:
    70. Domain for 2wg1:
    71. Domain for 2wg2:
    72. Domains for 2xi4:
      1. 2474481Domain d2xi4a_: 2xi4 A: [170108]
        automated match to d1evea_
        complexed with aft, cl, k, nag, peg, pge
      2. 2474482Domain d2xi4b_: 2xi4 B: [170109]
        automated match to d1evea_
        complexed with aft, cl, k, nag, peg, pge
    73. Domain for 3gel:
    74. Domain for 3i6m:
    75. Domain for 3i6z:
    76. Domain for 3m3d:
    77. Domain for 4tvk:
    78. Domain for 4w63:
    79. Domain for 5bwb:
    80. Domain for 5bwc:
    81. Domain for 5dlp:
    82. Domain for 5e2i:
    83. Domain for 5e4j:
    84. Domain for 5e4t:
      • 2474542Domain d5e4ta_: 5e4t A: [313546]
        automated match to d1e66a_
        complexed with bma, edo, fuc, man, mbt, nag, peg, pge
    85. Domain for 5ehx:
    86. Domain for 5ei5:
    87. Domain for 5ih7:
    88. Domain for 5nap:
    89. Domain for 5nau:
    90. Domain for 5nuu:
    91. Domain for 6g17:
  6. 3056698Tetronarce californica [TaxId:7787] [356760] (2 PDB entries)
    1. Domain for 6fld:
    2. Domain for 6fqn:

More info for Protein Acetylcholinesterase from c.69.1.1: Acetylcholinesterase-like

Timeline for Protein Acetylcholinesterase from c.69.1.1: Acetylcholinesterase-like: