Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily) core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest |
Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families) many members have left-handed crossover connection between strand 8 and additional strand 9 |
c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins) automatically mapped to Pfam PF00135 |
c.69.1.2: Carboxylesterase [53487] (7 proteins) |
c.69.1.3: Mycobacterial antigens [53491] (5 proteins) automatically mapped to Pfam PF00756 |
c.69.1.4: Prolyl oligopeptidase, C-terminal domain [53496] (2 proteins) N-terminal domain is a 7-bladed beta-propeller automatically mapped to Pfam PF00326 |
c.69.1.5: Serine carboxypeptidase-like [53499] (4 proteins) automatically mapped to Pfam PF00450 |
c.69.1.6: Gastric lipase [53506] (2 proteins) |
c.69.1.7: Proline iminopeptidase-like [53509] (4 proteins) |
c.69.1.8: Haloalkane dehalogenase [53513] (2 proteins) |
c.69.1.9: Dienelactone hydrolase [53518] (2 proteins) automatically mapped to Pfam PF01738 |
c.69.1.10: Carbon-carbon bond hydrolase [53522] (3 proteins) closely related to the Proline iminopeptidase-like family |
c.69.1.11: Epoxide hydrolase [53525] (3 proteins) |
c.69.1.12: Haloperoxidase [53531] (8 proteins) automatically mapped to Pfam PF12697 automatically mapped to Pfam PF00561 |
c.69.1.13: Thioesterases [53542] (4 proteins) |
c.69.1.14: Carboxylesterase/thioesterase 1 [53547] (5 proteins) |
c.69.1.15: A novel bacterial esterase [53552] (2 proteins) |
c.69.1.16: Lipase [53555] (2 proteins) |
c.69.1.17: Fungal lipases [53558] (5 proteins) |
c.69.1.18: Bacterial lipase [53570] (4 proteins) lack the first two strands of the common fold |
c.69.1.19: Pancreatic lipase, N-terminal domain [53577] (2 proteins) automatically mapped to Pfam PF00151 |
c.69.1.20: Hydroxynitrile lyase-like [53585] (3 proteins) automatically mapped to Pfam PF12697 |
c.69.1.21: PepX catalytic domain-like [69581] (4 proteins) |
c.69.1.22: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4 proteins) Pfam PF00975 |
c.69.1.23: Ccg1/TafII250-interacting factor B (Cib) [75285] (1 protein) |
c.69.1.24: DPP6 catalytic domain-like [82497] (2 proteins) N-terminal domain is a 8-bladed beta-propeller automatically mapped to Pfam PF00326 |
c.69.1.25: Acetyl xylan esterase-like [82504] (3 proteins) Pfam PF05448; AXE1 |
c.69.1.26: Biotin biosynthesis protein BioH [82509] (2 proteins) automatically mapped to Pfam PF12697 automatically mapped to Pfam PF00561 |
c.69.1.27: Hypothetical protein TT1662 [102616] (1 protein) automatically mapped to Pfam PF12697 |
c.69.1.28: Aclacinomycin methylesterase RdmC [102620] (1 protein) automatically mapped to Pfam PF12697 |
c.69.1.29: Carboxylesterase/lipase [102623] (1 protein) automatically mapped to Pfam PF12697 |
c.69.1.30: Cutinase-like [52260] (3 proteins) minimal alpha/beta hydrolase lacking peripheral secondary structures; similar to a flavodoxin-like fold automatically mapped to Pfam PF01083 |
c.69.1.31: YdeN-like [110699] (1 protein) Pfam PF06821; DUF1234; lack the first two strands of the common fold |
c.69.1.32: Putative serine hydrolase Ydr428c [110702] (1 protein) |
c.69.1.33: Acylamino-acid-releasing enzyme, C-terminal donain [117711] (1 protein) closely related to the prolyl peptidase and DPP6 domains ((53496) and 82497) automatically mapped to Pfam PF12697 |
c.69.1.34: Hypothetical esterase YJL068C [117714] (2 proteins) part of Pfam PF00756 |
c.69.1.35: Hypothetical protein VC1974 [117717] (1 protein) automatically mapped to Pfam PF00561 automatically mapped to Pfam PF12697 |
c.69.1.36: Atu1826-like [159742] (2 proteins) |
c.69.1.37: PHB depolymerase-like [159747] (1 protein) |
c.69.1.38: IroE-like [159750] (1 protein) |
c.69.1.39: TTHA1544-like [159753] (2 proteins) minimal hydrolase fold (one strand less than the cutinase-like family); there is neither catalytic triad, nor nucleopilic residue in the elbow motif |
c.69.1.40: O-acetyltransferase [159756] (2 proteins) |
c.69.1.41: 2,6-dihydropseudooxynicotine hydrolase-like [159762] (1 protein) Pfam PF06500; DUF1100 |
c.69.1.0: automated matches [191404] (1 protein) not a true family |
Timeline for Superfamily c.69.1: alpha/beta-Hydrolases: