SCOP 1.75: Superfamily c.69.1: alpha/beta-Hydrolases

Lineage for Superfamily c.69.1: alpha/beta-Hydrolases

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (41 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

Families:

1. c.69.1.1: Acetylcholinesterase-like [53475] (5 proteins)

2. c.69.1.2: Carboxylesterase [53487] (6 proteins)

3. c.69.1.3: Mycobacterial antigens [53491] (4 proteins)

4. c.69.1.4: Prolyl oligopeptidase, C-terminal domain [53496] (1 protein)
   N-terminal domain is a 7-bladed beta-propeller

5. c.69.1.5: Serine carboxypeptidase-like [53499] (3 proteins)

6. c.69.1.6: Gastric lipase [53506] (1 protein)

7. c.69.1.7: Proline iminopeptidase-like [53509] (3 proteins)

8. c.69.1.8: Haloalkane dehalogenase [53513] (1 protein)

9. c.69.1.9: Dienelactone hydrolase [53518] (1 protein)

10. c.69.1.10: Carbon-carbon bond hydrolase [53522] (3 proteins)
    closely related to the Proline iminopeptidase-like family

11. c.69.1.11: Epoxide hydrolase [53525] (2 proteins)

12. c.69.1.12: Haloperoxidase [53531] (7 proteins)

13. c.69.1.13: Thioesterases [53542] (3 proteins)

14. c.69.1.14: Carboxylesterase/thioesterase 1 [53547] (4 proteins)

15. c.69.1.15: A novel bacterial esterase [53552] (1 protein)

16. c.69.1.16: Lipase [53555] (1 protein)

17. c.69.1.17: Fungal lipases [53558] (4 proteins)

18. c.69.1.18: Bacterial lipase [53570] (3 proteins)
    lack the first two strands of the common fold

19. c.69.1.19: Pancreatic lipase, N-terminal domain [53577] (1 protein)

20. c.69.1.20: Hydroxynitrile lyase-like [53585] (2 proteins)

21. c.69.1.21: PepX catalytic domain-like [69581] (3 proteins)

22. c.69.1.22: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4 proteins)
    Pfam PF00975

23. c.69.1.23: Ccg1/TafII250-interacting factor B (Cib) [75285] (1 protein)

24. c.69.1.24: DPP6 catalytic domain-like [82497] (2 proteins)
    N-terminal domain is a 8-bladed beta-propeller

25. c.69.1.25: Acetyl xylan esterase-like [82504] (2 proteins)
    Pfam PF05448; AXE1

26. c.69.1.26: Biotin biosynthesis protein BioH [82509] (1 protein)

27. c.69.1.27: Hypothetical protein TT1662 [102616] (1 protein)

28. c.69.1.28: Aclacinomycin methylesterase RdmC [102620] (1 protein)

29. c.69.1.29: Carboxylesterase/lipase [102623] (1 protein)

30. c.69.1.30: Cutinase-like [52260] (2 proteins)
    minimal alpha/beta hydrolase lacking peripheral secondary structures; similar to a flavodoxin-like fold

31. c.69.1.31: YdeN-like [110699] (1 protein)
    Pfam PF06821; DUF1234; lack the first two strands of the common fold

32. c.69.1.32: Putative serine hydrolase Ydr428c [110702] (1 protein)

33. c.69.1.33: Acylamino-acid-releasing enzyme, C-terminal donain [117711] (1 protein)
    closely related to the prolyl peptidase and DPP6 domains ((53496) and 82497)
    closely related to the prolyl peptidase and DPP6 domains ((53496) and 82497)

34. c.69.1.34: Hypothetical esterase YJL068C [117714] (1 protein)
    part of Pfam PF00756

35. c.69.1.35: Hypothetical protein VC1974 [117717] (1 protein)

36. c.69.1.36: Atu1826-like [159742] (2 proteins)

37. c.69.1.37: PHB depolymerase-like [159747] (1 protein)

38. c.69.1.38: IroE-like [159750] (1 protein)

39. c.69.1.39: TTHA1544-like [159753] (1 protein)
    minimal hydrolase fold (one strand less than the cutinase-like family); there is neither catalytic triad, nor nucleopilic residue in the elbow motif

40. c.69.1.40: O-acetyltransferase [159756] (2 proteins)

41. c.69.1.41: 2,6-dihydropseudooxynicotine hydrolase-like [159762] (1 protein)
    Pfam PF06500; DUF1100

More info for Superfamily c.69.1: alpha/beta-Hydrolases

Timeline for Superfamily c.69.1: alpha/beta-Hydrolases:

• Superfamily c.69.1: alpha/beta-Hydrolases first appeared (with stable ids) in SCOP 1.55
  
• Superfamily c.69.1: alpha/beta-Hydrolases appears in SCOP 1.73
  
• Superfamily c.69.1: alpha/beta-Hydrolases appears in SCOPe 2.01
  
• Superfamily c.69.1: alpha/beta-Hydrolases appears in the current release, SCOPe 2.08