Lineage for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 999457Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 999458Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families) (S)

Families:

  1. 999459c.66.1.1: COMT-like [53336] (4 proteins)
  2. 999508c.66.1.2: RNA methyltransferase FtsJ [53339] (1 protein)
  3. 999513c.66.1.3: Fibrillarin homologue [53342] (2 proteins)
  4. 999529c.66.1.4: Hypothetical protein MJ0882 [53345] (1 protein)
  5. 999533c.66.1.5: Glycine N-methyltransferase [53348] (1 protein)
  6. 999592c.66.1.6: Arginine methyltransferase [53351] (3 proteins)
    lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain
  7. 999611c.66.1.7: Protein-L-isoaspartyl O-methyltransferase [53354] (1 protein)
    topological variant; strand order 3214567; strand 6 is antiparallel to the rest
  8. 999632c.66.1.8: Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1 protein)
    contains additional N-terminal all-alpha domain, res. 11-91
  9. 999637c.66.1.11: Type II DNA methylase [53377] (3 proteins)
    circularly permuted version of the common fold
  10. 999652c.66.1.12: Plant O-methyltransferase, C-terminal domain [64111] (5 proteins)
  11. 999682c.66.1.13: tRNA(1-methyladenosine) methyltransferase-like [64117] (5 proteins)
    contains additional N-terminal beta-sandwich domain
  12. 999698c.66.1.14: Hypothetical protein HI0319 (YecO) [69544] (1 protein)
  13. 999703c.66.1.15: Arylamine N-methyltransferase [69547] (3 proteins)
  14. 999787c.66.1.16: Guanidinoacetate methyltransferase [69550] (1 protein)
  15. 999804c.66.1.17: Spermidine synthase [69557] (3 proteins)
    contains additional N-terminal tetramerisation all-beta domain, res. 1-71
  16. 999868c.66.1.18: Mycolic acid cyclopropane synthase [69560] (7 proteins)
  17. 999904c.66.1.19: Histamine methyltransferase [75261] (1 protein)
  18. 999921c.66.1.20: Glucose-inhibited division protein B (GidB) [75264] (1 protein)
  19. 999927c.66.1.21: Hypothetical Protein YjhP [82469] (1 protein)
  20. 999933c.66.1.22: Precorrin-6Y methyltransferase (CbiT) [82472] (1 protein)
  21. 999966c.66.1.23: MraW-like putative methyltransferases [82475] (1 protein)
  22. 999976c.66.1.24: rRNA adenine dimethylase-like [88784] (5 proteins)
  23. 1000000c.66.1.25: mRNA cap methylase [88785] (3 proteins)
  24. 1000062c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (4 proteins)
  25. 1000106c.66.1.27: DNA methylase TaqI, N-terminal domain [88787] (1 protein)
  26. 1000131c.66.1.28: N6 adenine-specific DNA methylase, DAM [88788] (2 proteins)
  27. 1000155c.66.1.29: rRNA methyltransferase AviRa [89738] (1 protein)
  28. 1000160c.66.1.30: N5-glutamine methyltransferase, HemK [89743] (2 proteins)
  29. 1000176c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)
  30. 1000187c.66.1.32: Ta1320-like [89751] (2 proteins)
  31. 1000198c.66.1.33: rRNA methyltransferase RlmA [102557] (1 protein)
  32. 1000203c.66.1.34: mRNA cap (Guanine N-7) methyltransferase [102560] (1 protein)
    mRNA capping enzyme
  33. 1000213c.66.1.35: Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1 protein)
  34. 1000217c.66.1.36: Thiopurine S-methyltransferase [102566] (1 protein)
  35. 1000225c.66.1.37: Leucine carboxy methyltransferase Ppm1 [102569] (1 protein)
  36. 1000244c.66.1.38: NOL1/NOP2/sun [102575] (3 proteins)
    Pfam PF01189; contains additional N-terminal 3-helical and ferredoxin-like domains
  37. 1000255c.66.1.39: Ribosomal protein L11 methyltransferase PrmA [102578] (1 protein)
    contains additional N-terminal ferredoxin-like domain
  38. 1000270c.66.1.40: (Uracil-5-)-methyltransferase [102581] (1 protein)
    Pfam PF05958
  39. 1000276c.66.1.41: UbiE/COQ5-like [110671] (5 proteins)
    Pfam PF01209
  40. 1000305c.66.1.42: AD-003 protein-like [117685] (3 proteins)
    Pfam PF05891; DUF858
  41. 1000315c.66.1.43: CAC2371-like [117688] (3 proteins)
    similar overall fold to the Glycine N-methyltransferase (53348) and mRNA cap (Guanine N-7) methyltransferase (102560) families
  42. 1000328c.66.1.44: TehB-like [142603] (2 proteins)
    Pfam PF03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam PF05724)
  43. 1000342c.66.1.45: N-6 DNA Methylase-like [142606] (3 proteins)
    Pfam PF02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (88788)
  44. 1000354c.66.1.46: YhhF-like [142611] (6 proteins)
    Pfam PF03602
  45. 1000380c.66.1.47: Met-10+ protein-like [142622] (1 protein)
    Pfam PF02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf (102740)
  46. 1000384c.66.1.48: Nsp15 N-terminal domain-like [142625] (1 protein)
    rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain
  47. 1000401c.66.1.49: BC2162-like [142629] (2 proteins)
    contains extra helical regions inserted after strands 5 and 6 of the canonical fold
  48. 1000410c.66.1.50: CmcI-like [142632] (1 protein)
    Pfam PF04989; may have evolved different enzymatic activity
  49. 1000449c.66.1.51: hypothetical RNA methyltransferase [142635] (4 proteins)
    C-terminal part of Pfam PF03602; similar to (Uracil-5-)-methyltransferase (Pfam PF05958)
  50. 1000474c.66.1.52: RPA4359-like [142644] (1 protein)
    Pfam PF02636; DUF185
  51. 1000479c.66.1.53: TrmB-like [142647] (1 protein)
    Pfam PF02390
  52. 1000487c.66.1.54: Methyltransferase 10 domain [142651] (2 proteins)
    Pfam PF05971; DUF890
  53. 1000495c.66.1.55: YhiQ-like [159686] (1 protein)
    Pfam PF04445; DUF548; contains extra N-terminal alpha+beta subdomain [beta-alpha-beta(4)]
  54. 1000503c.66.1.56: FkbM-like [159691] (1 protein)
    contains extra N-terminal alpha/beta and all-alpha subdomains
  55. 1000507c.66.1.57: ML2640-like [159694] (2 proteins)
    Pfam PF02409; O-methyltransferase N-terminus (DUF142); most similar structure to the Leucine carboxy methyltransferase Ppm1 family
  56. 1000516c.66.1.58: TRM1-like [159697] (1 protein)
    Pfam PF02005; contains extra C-terminal alpha+beta subdomain
  57. 1000524c.66.1.59: LPG1296-like [159700] (1 protein)
    Pfam PF04378; DUF519
  58. 1000528c.66.1.0: automated matches [191451] (1 protein)
    not a true family

More info for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

Timeline for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases: