SCOPe 2.02: Family c.56.2.1: Purine and uridine phosphorylases

Lineage for Family c.56.2.1: Purine and uridine phosphorylases

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (2 families)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (7 proteins)

Proteins:

1. 5'-deoxy-5'-methylthioadenosine phosphorylase [53174] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [53175] (8 PDB entries)
      Uniprot Q13126

   2. Species Sulfolobus solfataricus [TaxId:2287] [69536] (9 PDB entries)

   3. Species Sulfolobus tokodaii [TaxId:111955] [117657] (1 PDB entry)
      Uniprot Q975C3

2. 5'-Methylthioadenosine/S-Adenosylhomocysteine nucleosidase [82448] (3 species)

   1. Species Escherichia coli [TaxId:562] [82449] (8 PDB entries)

   2. Species Neisseria meningitidis [TaxId:491] [188964] (1 PDB entry)

   3. Species Staphylococcus aureus [TaxId:1280] [188463] (1 PDB entry)

3. AMP nucleosidase [110645] (2 species)
   contains extra N-terminal oligomerisation (sub)domain (8-153)

   1. Species Bacteroides thetaiotaomicron [TaxId:818] [117658] (1 PDB entry)
      Uniprot Q7MVU1

   2. Species Escherichia coli [TaxId:562] [110646] (4 PDB entries)
      Uniprot P15272

4. Purine nucleoside phosphorylase, PNP [53169] (11 species)

   1. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [117655] (1 PDB entry)
      Uniprot Q81T09

   2. Species Bacillus cereus [TaxId:1396] [195935] (3 PDB entries)

   3. Species Bacillus cereus [TaxId:269801] [186942] (1 PDB entry)

   4. Species Cellulomonas sp. [TaxId:40001] [53173] (2 PDB entries)

   5. Species Cow (Bos taurus) [TaxId:9913] [53171] (20 PDB entries)
      Uniprot P55859

   6. Species Escherichia coli [TaxId:562] [53172] (21 PDB entries)

   7. Species Human (Homo sapiens) [TaxId:9606] [53170] (27 PDB entries)
      Uniprot P00491

   8. Species Mycobacterium tuberculosis [TaxId:1773] [64098] (3 PDB entries)

   9. Species Thermotoga maritima [TaxId:2336] [117654] (1 PDB entry)
      Uniprot Q9X1T2

   10. Species Thermus thermophilus [TaxId:274] [89721] (4 PDB entries)

   11. Species Vibrio cholerae [TaxId:666] [102499] (2 PDB entries)

5. Putative uridine phosphorylase [102500] (1 species)

   • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [102501] (3 PDB entries)

6. Uridine phosphorylase [53176] (2 species)

   1. Species Escherichia coli [TaxId:562] [53177] (15 PDB entries)

   2. Species Salmonella typhimurium [TaxId:90371] [117656] (23 PDB entries)
      Uniprot P0A1F6

7. automated matches [190142] (15 species)
   not a true protein

   1. Species Aeropyrum pernix [TaxId:272557] [188092] (1 PDB entry)

   2. Species Bacillus subtilis [TaxId:1423] [193503] (1 PDB entry)

   3. Species Cow (Bos taurus) [TaxId:9913] [187265] (1 PDB entry)

   4. Species Escherichia coli [TaxId:562] [186867] (2 PDB entries)

   5. Species Klebsiella pneumoniae [TaxId:272620] [193517] (1 PDB entry)

   6. Species Mycobacterium tuberculosis [TaxId:1773] [189596] (2 PDB entries)

   7. Species Plasmodium falciparum [TaxId:36329] [186993] (2 PDB entries)

   8. Species Plasmodium vivax [TaxId:5855] [188970] (1 PDB entry)

   9. Species Salmonella enterica [TaxId:904139] [196952] (2 PDB entries)

   10. Species Salmonella typhimurium [TaxId:99287] [187772] (1 PDB entry)

   11. Species Sulfolobus solfataricus [TaxId:2287] [187383] (2 PDB entries)

   12. Species Trichomonas vaginalis [TaxId:5722] [187838] (9 PDB entries)

   13. Species Vibrio cholerae [TaxId:243277] [189490] (2 PDB entries)

   14. Species Vibrio cholerae [TaxId:666] [188799] (2 PDB entries)

   15. Species Yersinia pseudotuberculosis [TaxId:502800] [189524] (1 PDB entry)

More info for Family c.56.2.1: Purine and uridine phosphorylases

Timeline for Family c.56.2.1: Purine and uridine phosphorylases:

• Family c.56.2.1: Purine and uridine phosphorylases first appeared (with stable ids) in SCOP 1.55
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOPe 2.01
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOPe 2.03
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in the current release, SCOPe 2.08