SCOP 1.75: Family c.56.2.1: Purine and uridine phosphorylases

Lineage for Family c.56.2.1: Purine and uridine phosphorylases

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (1 family)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (6 proteins)

Proteins:

1. 5'-deoxy-5'-methylthioadenosine phosphorylase [53174] (3 species)

   1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69536] (9 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [53175] (5 PDB entries)
      Uniprot Q13126

   3. Species Sulfolobus tokodaii [TaxId:111955] [117657] (1 PDB entry)
      Uniprot Q975C3

2. 5'-Methylthioadenosine/S-Adenosylhomocysteine nucleosidase [82448] (1 species)

   • Species Escherichia coli [TaxId:562] [82449] (6 PDB entries)

3. AMP nucleosidase [110645] (2 species)
   contains extra N-terminal oligomerisation (sub)domain (8-153)

   1. Species Bacteroides thetaiotaomicron [TaxId:818] [117658] (1 PDB entry)
      Uniprot Q7MVU1

   2. Species Escherichia coli [TaxId:562] [110646] (4 PDB entries)
      Uniprot P15272

4. Purine nucleoside phosphorylase, PNP [53169] (9 species)

   1. Species Bacillus anthracis [TaxId:1392] [117655] (2 PDB entries)
      Uniprot Q81T09

   2. Species Cellulomonas sp. [TaxId:40001] [53173] (2 PDB entries)

   3. Species Cow (Bos taurus) [TaxId:9913] [53171] (20 PDB entries)
      Uniprot P55859

   4. Species Escherichia coli [TaxId:562] [53172] (19 PDB entries)

   5. Species Human (Homo sapiens) [TaxId:9606] [53170] (17 PDB entries)
      Uniprot P00491

   6. Species Mycobacterium tuberculosis [TaxId:1773] [64098] (3 PDB entries)

   7. Species Thermotoga maritima [TaxId:2336] [117654] (1 PDB entry)
      Uniprot Q9X1T2

   8. Species Thermus thermophilus [TaxId:274] [89721] (4 PDB entries)

   9. Species Vibrio cholerae [TaxId:666] [102499] (2 PDB entries)

5. Putative uridine phosphorylase [102500] (1 species)

   • Species Plasmodium falciparum [TaxId:5833] [102501] (4 PDB entries)

6. Uridine phosphorylase [53176] (2 species)

   1. Species Escherichia coli [TaxId:562] [53177] (13 PDB entries)
      also includes the PDB entry (1rxs) where protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP
      also includes the PDB entry (1rxs) where protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP

   2. Species Salmonella typhimurium [TaxId:90371] [117656] (1 PDB entry)
      Uniprot P0A1F6

More info for Family c.56.2.1: Purine and uridine phosphorylases

Timeline for Family c.56.2.1: Purine and uridine phosphorylases:

• Family c.56.2.1: Purine and uridine phosphorylases first appeared (with stable ids) in SCOP 1.55
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOP 1.73
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOPe 2.01
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in the current release, SCOPe 2.08