SCOP 1.73: Family c.56.2.1: Purine and uridine phosphorylases

Lineage for Family c.56.2.1: Purine and uridine phosphorylases

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (7 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (1 family)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (6 proteins)

Proteins:

1. 5'-deoxy-5'-methylthioadenosine phosphorylase [53174] (3 species)

   1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69536] (9 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [53175] (5 PDB entries)

   3. Species Sulfolobus tokodaii [TaxId:111955] [117657] (1 PDB entry)

2. 5'-Methylthioadenosine/S-Adenosylhomocysteine nucleosidase [82448] (1 species)

   • Species Escherichia coli [TaxId:562] [82449] (6 PDB entries)

3. AMP nucleosidase [110645] (2 species)
   contains extra N-terminal oligomerisation (sub)domain (8-153)

   1. Species Bacteroides thetaiotaomicron [TaxId:818] [117658] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [110646] (4 PDB entries)

4. Purine nucleoside phosphorylase, PNP [53169] (9 species)

   1. Species Bacillus anthracis [TaxId:1392] [117655] (2 PDB entries)

   2. Species Cellulomonas sp. [TaxId:40001] [53173] (2 PDB entries)

   3. Species Cow (Bos taurus) [TaxId:9913] [53171] (19 PDB entries)

   4. Species Escherichia coli [TaxId:562] [53172] (19 PDB entries)

   5. Species Human (Homo sapiens) [TaxId:9606] [53170] (15 PDB entries)

   6. Species Mycobacterium tuberculosis [TaxId:1773] [64098] (3 PDB entries)

   7. Species Thermotoga maritima [TaxId:2336] [117654] (1 PDB entry)

   8. Species Thermus thermophilus [TaxId:274] [89721] (4 PDB entries)

   9. Species Vibrio cholerae [TaxId:666] [102499] (2 PDB entries)

5. Putative uridine phosphorylase [102500] (1 species)

   • Species Plasmodium falciparum [TaxId:5833] [102501] (4 PDB entries)

6. Uridine phosphorylase [53176] (2 species)

   1. Species Escherichia coli [TaxId:562] [53177] (13 PDB entries)
      also includes the PDB entry (1rxs) where protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP

   2. Species Salmonella typhimurium [TaxId:90371] [117656] (1 PDB entry)

More info for Family c.56.2.1: Purine and uridine phosphorylases

Timeline for Family c.56.2.1: Purine and uridine phosphorylases:

• Family c.56.2.1: Purine and uridine phosphorylases first appeared (with stable ids) in SCOP 1.55
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOP 1.71
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in SCOP 1.75
  
• Family c.56.2.1: Purine and uridine phosphorylases appears in the current release, SCOPe 2.08