Lineage for Protein: Mammalian type I hexokinase

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2460924Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
  4. 2460925Superfamily c.55.1: Actin-like ATPase domain [53067] (16 families) (S)
    duplication contains two domains of this fold
  5. 2461618Family c.55.1.3: Hexokinase [53083] (3 protein domains)
  6. 2461640Protein Mammalian type I hexokinase [53086] (2 species)
    further duplication: consists of two very similar lobes

Species:

  1. 2461641Human (Homo sapiens) [TaxId:9606] [53087] (10 PDB entries)
    1. Domains for 1cza:
      1. 2461642Domain d1czan1: 1cza N:16-222 [33463]
        complexed with adp, g6p, glc; mutant
      2. 2461643Domain d1czan2: 1cza N:223-465 [33464]
        complexed with adp, g6p, glc; mutant
      3. 2461644Domain d1czan3: 1cza N:466-670 [33465]
        complexed with adp, g6p, glc; mutant
      4. 2461645Domain d1czan4: 1cza N:671-913 [33466]
        complexed with adp, g6p, glc; mutant
    2. Domains for 1dgk:
      1. 2461698Domain d1dgkn1: 1dgk N:16-222 [33487]
        complexed with adp, glc, po4; mutant
      2. 2461699Domain d1dgkn2: 1dgk N:223-465 [33488]
        complexed with adp, glc, po4; mutant
      3. 2461700Domain d1dgkn3: 1dgk N:466-670 [33489]
        complexed with adp, glc, po4; mutant
      4. 2461701Domain d1dgkn4: 1dgk N:671-913 [33490]
        complexed with adp, glc, po4; mutant
    3. Domains for 1hkb:
      1. 2461690Domain d1hkba1: 1hkb A:16-222 [33479]
        complexed with bgc, ca, g6p
      2. 2461691Domain d1hkba2: 1hkb A:223-465 [33480]
        complexed with bgc, ca, g6p
      3. 2461692Domain d1hkba3: 1hkb A:466-670 [33481]
        complexed with bgc, ca, g6p
      4. 2461693Domain d1hkba4: 1hkb A:671-914 [33482]
        complexed with bgc, ca, g6p
      5. 2461694Domain d1hkbb1: 1hkb B:16-222 [33483]
        complexed with bgc, ca, g6p
      6. 2461695Domain d1hkbb2: 1hkb B:223-465 [33484]
        complexed with bgc, ca, g6p
      7. 2461696Domain d1hkbb3: 1hkb B:466-670 [33485]
        complexed with bgc, ca, g6p
      8. 2461697Domain d1hkbb4: 1hkb B:671-914 [33486]
        complexed with bgc, ca, g6p
    4. Domains for 1hkc:
      1. 2461662Domain d1hkca1: 1hkc A:16-222 [33475]
        complexed with bgc, k, po4
      2. 2461663Domain d1hkca2: 1hkc A:223-465 [33476]
        complexed with bgc, k, po4
      3. 2461664Domain d1hkca3: 1hkc A:466-670 [33477]
        complexed with bgc, k, po4
      4. 2461665Domain d1hkca4: 1hkc A:671-914 [33478]
        complexed with bgc, k, po4
    5. Domains for 1qha:
      1. 2461646Domain d1qhaa1: 1qha A:12-222 [33467]
        complexed with anp, g6p, glc, mg
      2. 2461647Domain d1qhaa2: 1qha A:223-465 [33468]
        complexed with anp, g6p, glc, mg
      3. 2461648Domain d1qhaa3: 1qha A:466-670 [33469]
        complexed with anp, g6p, glc, mg
      4. 2461649Domain d1qhaa4: 1qha A:671-914 [33470]
        complexed with anp, g6p, glc, mg
      5. 2461650Domain d1qhab1: 1qha B:16-222 [33471]
        complexed with anp, g6p, glc, mg
      6. 2461651Domain d1qhab2: 1qha B:223-465 [33472]
        complexed with anp, g6p, glc, mg
      7. 2461652Domain d1qhab3: 1qha B:466-670 [33473]
        complexed with anp, g6p, glc, mg
      8. 2461653Domain d1qhab4: 1qha B:671-914 [33474]
        complexed with anp, g6p, glc, mg
    6. Domains for 4f9o:
      1. 2461674Domain d4f9oa1: 4f9o A:16-222 [251937]
        automated match to d1czan1
        complexed with 0nz, bgc, cit, na
      2. 2461675Domain d4f9oa2: 4f9o A:223-465 [251938]
        automated match to d1czan2
        complexed with 0nz, bgc, cit, na
      3. 2461676Domain d4f9oa3: 4f9o A:466-670 [251939]
        automated match to d1czan3
        complexed with 0nz, bgc, cit, na
      4. 2461677Domain d4f9oa4: 4f9o A:671-914 [251940]
        automated match to d1czan4
        complexed with 0nz, bgc, cit, na
      5. 2461678Domain d4f9ob1: 4f9o B:16-222 [251941]
        automated match to d1czan1
        complexed with 0nz, bgc, cit, na
      6. 2461679Domain d4f9ob2: 4f9o B:223-465 [251942]
        automated match to d1czan2
        complexed with 0nz, bgc, cit, na
      7. 2461680Domain d4f9ob3: 4f9o B:466-670 [251943]
        automated match to d1czan3
        complexed with 0nz, bgc, cit, na
      8. 2461681Domain d4f9ob4: 4f9o B:671-914 [251944]
        automated match to d1czan4
        complexed with 0nz, bgc, cit, na
    7. Domains for 4foe:
      1. 2461682Domain d4foea1: 4foe A:16-222 [221393]
        automated match to d1hkba1
        complexed with bgc, cit, m6d, na
      2. 2461683Domain d4foea2: 4foe A:223-465 [221394]
        automated match to d1hkba2
        complexed with bgc, cit, m6d, na
      3. 2461684Domain d4foea3: 4foe A:466-670 [221395]
        automated match to d1hkba3
        complexed with bgc, cit, m6d, na
      4. 2461685Domain d4foea4: 4foe A:671-914 [221396]
        automated match to d1hkba4
        complexed with bgc, cit, m6d, na
      5. 2461686Domain d4foeb1: 4foe B:16-222 [221397]
        automated match to d1hkba1
        complexed with bgc, cit, m6d, na
      6. 2461687Domain d4foeb2: 4foe B:223-465 [221398]
        automated match to d1hkba2
        complexed with bgc, cit, m6d, na
      7. 2461688Domain d4foeb3: 4foe B:466-670 [221399]
        automated match to d1hkba3
        complexed with bgc, cit, m6d, na
      8. 2461689Domain d4foeb4: 4foe B:671-914 [221400]
        automated match to d1hkba4
        complexed with bgc, cit, m6d, na
    8. Domains for 4foi:
      1. 2461654Domain d4foia1: 4foi A:16-222 [252045]
        automated match to d1czan1
        complexed with bgc, cit, g16, na; mutant
      2. 2461655Domain d4foia2: 4foi A:223-465 [252046]
        automated match to d1czan2
        complexed with bgc, cit, g16, na; mutant
      3. 2461656Domain d4foia3: 4foi A:466-670 [252047]
        automated match to d1czan3
        complexed with bgc, cit, g16, na; mutant
      4. 2461657Domain d4foia4: 4foi A:671-914 [252048]
        automated match to d1czan4
        complexed with bgc, cit, g16, na; mutant
      5. 2461658Domain d4foib1: 4foi B:16-222 [252049]
        automated match to d1czan1
        complexed with bgc, cit, g16, na; mutant
      6. 2461659Domain d4foib2: 4foi B:223-465 [252050]
        automated match to d1czan2
        complexed with bgc, cit, g16, na; mutant
      7. 2461660Domain d4foib3: 4foi B:466-670 [252051]
        automated match to d1czan3
        complexed with bgc, cit, g16, na; mutant
      8. 2461661Domain d4foib4: 4foi B:671-914 [252052]
        automated match to d1czan4
        complexed with bgc, cit, g16, na; mutant
    9. Domains for 4fpa:
      1. 2461666Domain d4fpaa1: 4fpa A:16-222 [252053]
        automated match to d1czan1
        complexed with bg6, bgc, cit, na; mutant
      2. 2461667Domain d4fpaa2: 4fpa A:223-465 [252054]
        automated match to d1czan2
        complexed with bg6, bgc, cit, na; mutant
      3. 2461668Domain d4fpaa3: 4fpa A:466-670 [252055]
        automated match to d1czan3
        complexed with bg6, bgc, cit, na; mutant
      4. 2461669Domain d4fpaa4: 4fpa A:671-914 [252056]
        automated match to d1czan4
        complexed with bg6, bgc, cit, na; mutant
      5. 2461670Domain d4fpab1: 4fpa B:16-222 [252057]
        automated match to d1czan1
        complexed with bg6, bgc, cit, na; mutant
      6. 2461671Domain d4fpab2: 4fpa B:223-465 [252058]
        automated match to d1czan2
        complexed with bg6, bgc, cit, na; mutant
      7. 2461672Domain d4fpab3: 4fpa B:466-670 [252059]
        automated match to d1czan3
        complexed with bg6, bgc, cit, na; mutant
      8. 2461673Domain d4fpab4: 4fpa B:671-914 [252060]
        automated match to d1czan4
        complexed with bg6, bgc, cit, na; mutant
    10. Domains for 4fpb:
      1. 2461702Domain d4fpba1: 4fpb A:16-222 [252061]
        automated match to d1czan1
        complexed with 0wk, bgc, cit, na
      2. 2461703Domain d4fpba2: 4fpb A:223-465 [252062]
        automated match to d1czan2
        complexed with 0wk, bgc, cit, na
      3. 2461704Domain d4fpba3: 4fpb A:466-670 [252063]
        automated match to d1czan3
        complexed with 0wk, bgc, cit, na
      4. 2461705Domain d4fpba4: 4fpb A:671-914 [252064]
        automated match to d1czan4
        complexed with 0wk, bgc, cit, na
      5. 2461706Domain d4fpbb1: 4fpb B:16-222 [252065]
        automated match to d1czan1
        complexed with 0wk, bgc, cit, na
      6. 2461707Domain d4fpbb2: 4fpb B:223-465 [252066]
        automated match to d1czan2
        complexed with 0wk, bgc, cit, na
      7. 2461708Domain d4fpbb3: 4fpb B:466-670 [252067]
        automated match to d1czan3
        complexed with 0wk, bgc, cit, na
      8. 2461709Domain d4fpbb4: 4fpb B:671-914 [252068]
        automated match to d1czan4
        complexed with 0wk, bgc, cit, na
  2. 2461710Norway rat (Rattus norvegicus) [TaxId:10116] [53088] (1 PDB entry)

More info for Protein Mammalian type I hexokinase from c.55.1.3: Hexokinase

Timeline for Protein Mammalian type I hexokinase from c.55.1.3: Hexokinase: