SCOPe 2.03: Family c.47.1.10: Glutathione peroxidase-like

Lineage for Family c.47.1.10: Glutathione peroxidase-like

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.47: Thioredoxin fold [52832] (2 superfamilies)
   core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest

4. Superfamily c.47.1: Thioredoxin-like [52833] (24 families)

5. Family c.47.1.10: Glutathione peroxidase-like [52901] (29 proteins)

Proteins:

1. 1-Cys peroxiredoxin [52909] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [52910] (1 PDB entry)

   2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [142367] (1 PDB entry)
      Uniprot Q5MYR6 60-238

   3. Species Plasmodium yoelii yoelii [TaxId:73239] [117599] (2 PDB entries)
      Uniprot Q7RGR1

2. Alkyl hydroperoxide reductase AhpC [69516] (4 species)

   1. Species Amphibacillus xylanus [TaxId:1449] [142369] (1 PDB entry)
      Uniprot O87200 2-167

   2. Species Mycobacterium tuberculosis [TaxId:1773] [142368] (1 PDB entry)
      Uniprot Q7BHK8 2-170

   3. Species Salmonella enterica [TaxId:90371] [229124] (1 PDB entry)

   4. Species Salmonella typhimurium [TaxId:90371] [69517] (5 PDB entries)

3. Bacterioferritin comigratory protein [142377] (1 species)

   • Species Aeropyrum pernix [TaxId:56636] [142378] (4 PDB entries)
     Uniprot Q9YA14 4-163

4. Glutathione peroxidase [52902] (2 species)
   contains many insertions in the common fold

   1. Species Cow (Bos taurus) [TaxId:9913] [52903] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [142365] (1 PDB entry)
      Uniprot P07203 12-195

5. Lipoprotein DsbF [142375] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [142376] (1 PDB entry)
     Uniprot O53924 47-180

6. Membrane-anchored thioredoxin-like protein TlpA, soluble domain [64068] (1 species)

   • Species Bradyrhizobium japonicum [TaxId:375] [64069] (1 PDB entry)

7. N-terminal, Prx domain of Hybrid-Prx5 [89708] (1 species)

   • Species Haemophilus influenzae [TaxId:727] [89709] (1 PDB entry)
     HI0572

8. Peptide methionine sulfoxide reductase MsrA/MsrB, N-terminal domain [142385] (2 species)

   1. Species Neisseria gonorrhoeae [TaxId:485] [187786] (1 PDB entry)

   2. Species Neisseria meningitidis serogroup A [TaxId:65699] [142386] (3 PDB entries)
      Uniprot Q9JWM8 33-175

9. Peroxiredoxin [117601] (1 species)

   • Species Aeropyrum pernix [TaxId:56636] [117602] (2 PDB entries)
     Uniprot Q9Y9L0 # APE2278

10. Peroxiredoxin 5 [64066] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [64067] (4 PDB entries)
      Uniprot P30044

11. Peroxiredoxin dot5 [142387] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [142388] (1 PDB entry)
      Uniprot P40553 59-214

12. Peroxiredoxin-3 (AOP-1, SP-22) [142391] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [142392] (1 PDB entry)
      Uniprot P35705 63-220

13. Phenol hydroxylase, C-terminal domain [52911] (1 species)

    • Species Soil-living yeast (Trichosporon cutaneum) [TaxId:5554] [52912] (2 PDB entries)

14. Plant peroxiredoxin [142379] (1 species)

    • Species Western balsam poplar (Populus trichocarpa) [TaxId:3694] [142380] (1 PDB entry)
      Uniprot Q8S3L0 1-162

15. Probable thiol peroxidase PsaD [89710] (1 species)

    • Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [89711] (1 PDB entry)

16. Probable thiol-disulfide isomerase/thioredoxin TTHA0593 [142389] (1 species)

    • Species Thermus thermophilus [TaxId:274] [142390] (2 PDB entries)
      Uniprot Q5SKQ0 2-188

17. Putative peroxiredoxin Rv2238c/MT2298 [142381] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [142382] (2 PDB entries)
      Uniprot P65688 1-153

18. Soluble secreted antigen MPT53 [102457] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [102458] (1 PDB entry)

19. Thiol peroxidase Tpx [102452] (4 species)

    1. Species Escherichia coli K-12 [TaxId:83333] [189089] (4 PDB entries)

    2. Species Escherichia coli [TaxId:562] [102453] (1 PDB entry)

    3. Species Haemophilus influenzae [TaxId:727] [102454] (1 PDB entry)
       HI0751

    4. Species Mycobacterium tuberculosis [TaxId:1773] [117600] (2 PDB entries)
       Uniprot P66952

20. Thiol-disulfide oxidoreductase ResA [102455] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [102456] (7 PDB entries)

21. thiol:disulfide oxidoreductase YkuV [142373] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [142374] (2 PDB entries)
      Uniprot O31699 1-143

22. Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin) [52906] (3 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [52908] (1 PDB entry)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [52907] (1 PDB entry)
       heme-binding protein 23, HBP23

    3. Species Plasmodium yoelii [TaxId:5861] [142366] (1 PDB entry)
       Uniprot Q86SB2 8-177

23. Thioredoxin reductase TsaA [142383] (1 species)

    • Species Helicobacter pylori [TaxId:210] [142384] (1 PDB entry)
      Uniprot P56876 1-170

24. Thioredoxin-like protein CcmG (CycY, DsbE) [75237] (2 species)

    1. Species Bradyrhizobium japonicum [TaxId:375] [75238] (1 PDB entry)

    2. Species Escherichia coli [TaxId:562] [142370] (1 PDB entry)
       Uniprot P0AA86 49-184

25. Thioredoxin-like protein Sco1 (YpmQ), soluble domain [102459] (3 species)

    1. Species Bacillus subtilis [TaxId:1423] [102460] (2 PDB entries)

    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [142372] (2 PDB entries)
       Uniprot P23833 111-262

    3. Species Human (Homo sapiens) [TaxId:9606] [142371] (2 PDB entries)
       Uniprot O75880 138-297

26. Tryparedoxin I [52904] (2 species)

    1. Species Crithidia fasciculata [TaxId:5656] [52905] (8 PDB entries)

    2. Species Trypanosoma brucei brucei [TaxId:5702] [89707] (1 PDB entry)

27. Tryparedoxin II [64062] (1 species)

    • Species Crithidia fasciculata [TaxId:5656] [64063] (6 PDB entries)

28. Tryparedoxin peroxidase (thioredoxin peroxidase homologue) [64064] (2 species)

    1. Species Crithidia fasciculata [TaxId:5656] [64065] (1 PDB entry)

    2. Species Trypanosoma cruzi [TaxId:5693] [117598] (1 PDB entry)
       Uniprot O96763

29. automated matches [190100] (15 species)
    not a true protein

    1. Species Aeropyrum pernix [TaxId:272557] [186846] (8 PDB entries)

    2. Species Aeropyrum pernix [TaxId:56636] [187260] (1 PDB entry)

    3. Species Amphibacillus xylanus [TaxId:1449] [186822] (1 PDB entry)

    4. Species Ancylostoma ceylanicum [TaxId:53326] [197299] (1 PDB entry)

    5. Species Arenicola marina [TaxId:6344] [188412] (4 PDB entries)

    6. Species Bacillus subtilis [TaxId:1423] [188552] (2 PDB entries)

    7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [226432] (1 PDB entry)

    8. Species Burkholderia cenocepacia [TaxId:216591] [196688] (1 PDB entry)

    9. Species Escherichia coli [TaxId:562] [187437] (1 PDB entry)

    10. Species Human (Homo sapiens) [TaxId:9606] [187259] (7 PDB entries)

    11. Species Leishmania major [TaxId:5664] [226407] (2 PDB entries)

    12. Species Mycobacterium tuberculosis [TaxId:1773] [186863] (1 PDB entry)

    13. Species Norway rat (Rattus norvegicus) [TaxId:10116] [225384] (1 PDB entry)

    14. Species Salmonella enterica [TaxId:90371] [229121] (1 PDB entry)

    15. Species Trypanosoma cruzi [TaxId:5693] [228237] (1 PDB entry)

More info for Family c.47.1.10: Glutathione peroxidase-like

Timeline for Family c.47.1.10: Glutathione peroxidase-like:

• Family c.47.1.10: Glutathione peroxidase-like first appeared (with stable ids) in SCOP 1.55
  
• Family c.47.1.10: Glutathione peroxidase-like appears in SCOPe 2.02
  
• Family c.47.1.10: Glutathione peroxidase-like appears in SCOPe 2.04
  
• Family c.47.1.10: Glutathione peroxidase-like appears in the current release, SCOPe 2.08