Lineage for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 698982Fold c.47: Thioredoxin fold [52832] (2 superfamilies)
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
  4. 698983Superfamily c.47.1: Thioredoxin-like [52833] (22 families) (S)
  5. 699243Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain [52862] (18 proteins)

Proteins:

  1. 699244Chloride intracellular channel 1 (clic1) [69514] (1 species)
    similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition
  2. 699254Class alpha GST [81360] (8 species)
    1. 699255Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89704] (8 PDB entries)
    2. 699270Species Fasciola hepatica [TaxId:6192] [52879] (2 PDB entries)
    3. 699274Species Human (Homo sapiens), (a1-1) [TaxId:9606] [52870] (17 PDB entries)
    4. 699327Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [52872] (2 PDB entries)
    5. 699332Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [52873] (2 PDB entries)
    6. 699337Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89703] (1 PDB entry)
    7. 699340Species Rat (Rattus norvegicus), (a1-1) [TaxId:10116] [52871] (2 PDB entries)
    8. 699347Species Schistosoma japonicum [TaxId:6182] [52878] (9 PDB entries)
  3. 699358Class beta GST [81368] (3 species)
    1. 699359Species Escherichia coli [TaxId:562] [52883] (3 PDB entries)
    2. 699365Species Proteus mirabilis [TaxId:584] [52884] (2 PDB entries)
    3. 699371Species Sphingomonas paucimobilis [TaxId:13689] [52885] (1 PDB entry)
  4. 699376Class delta GST [81366] (5 species)
    formerly a part of class theta enzymes
    1. 699377Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [102441] (1 PDB entry)
    2. 699380Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [75234] (1 PDB entry)
    3. 699387Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [75235] (1 PDB entry)
    4. 699390Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [102439] (1 PDB entry)
    5. 699392Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [102440] (1 PDB entry)
  5. 699397Class mu GST [81359] (3 species)
    1. 699398Species Chicken (Gallus gallus) [TaxId:9031] [52869] (2 PDB entries)
    2. 699405Species Human (Homo sapiens) [TaxId:9606] [52867] (15 PDB entries)
    3. 699459Species Rat (Rattus norvegicus) [TaxId:10116] [52868] (16 PDB entries)
  6. 699495Class omega GST [81363] (1 species)
  7. 699498Class phi GST [81367] (3 species)
    1. 699499Species Maize (Zea mays), type I [TaxId:4577] [52881] (2 PDB entries)
    2. 699506Species Maize (Zea mays), type III [TaxId:4577] [52882] (1 PDB entry)
    3. 699508Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [52880] (2 PDB entries)
  8. 699512Class pi GST [81358] (4 species)
    1. 699513Species Human (Homo sapiens) [TaxId:9606] [52864] (39 PDB entries)
    2. 699603Species Mouse (Mus musculus) [TaxId:10090] [52866] (9 PDB entries)
    3. 699626Species Onchocerca volvulus [TaxId:6282] [117595] (2 PDB entries)
    4. 699633Species Pig (Sus scrofa) [TaxId:9823] [52865] (1 PDB entry)
  9. 699636Class sigma GST [81362] (5 species)
    1. 699637Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [82427] (1 PDB entry)
    2. 699640Species Heligmosomoides polygyrus [TaxId:6339] [110608] (1 PDB entry)
    3. 699649Species Human (Homo sapiens) [TaxId:9606] [89705] (4 PDB entries)
      synonym: hematopoietic prostaglandin D synthase
    4. 699666Species Rat (Rattus norvegicus) [TaxId:10116] [52875] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase
    5. 699669Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [52876] (2 PDB entries)
  10. 699672Class tau GST [81365] (2 species)
    1. 699673Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [75236] (1 PDB entry)
    2. 699677Species Rice (Oryza sativa) [TaxId:4530] [89706] (1 PDB entry)
  11. 699682Class theta GST [81361] (1 species)
  12. 699690Class zeta GST [81364] (2 species)
    1. 699691Species Human (Homo sapiens) [TaxId:9606] [64058] (1 PDB entry)
      maleylacetoacetate isomerase
    2. 699693Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [64059] (1 PDB entry)
  13. 699695Glutaredoxin 2 [64060] (1 species)
    similar to class zeta enzymes
  14. 699698GST-like domain of elongation factor 1-gamma [82428] (1 species)
  15. 699701Hypothetical protein AGR_pAT_752p/Atu5508 [142361] (1 species)
    putative glutathione S-transferase
  16. 699705Microsomal prostaglandin E synthase-2 [142363] (1 species)
  17. 699711Pf GST [102442] (1 species)
    cannot be assigned to any of the known GST classes
  18. 699721Yeast prion protein ure2p, nitrogen regulation fragment [52886] (1 species)
    similar to class phi enzymes

More info for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

Timeline for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain: