Lineage for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2116932Fold c.47: Thioredoxin fold [52832] (2 superfamilies)
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
  4. 2116933Superfamily c.47.1: Thioredoxin-like [52833] (24 families) (S)
  5. 2117361Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain [52862] (19 protein domains)

Protein Domains:

  1. 2117362Chloride intracellular channel 1 (clic1) [69514] (1 species)
    similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition
  2. 2117372Class alpha GST [81360] (8 species)
    1. 2117373Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89704] (4 PDB entries)
    2. 2117381Species Fasciola hepatica [TaxId:6192] [52879] (2 PDB entries)
    3. 2117385Species Human (Homo sapiens), (a1-1) [TaxId:9606] [52870] (30 PDB entries)
      Uniprot P08263
    4. 2117478Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [52872] (2 PDB entries)
    5. 2117483Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [52873] (2 PDB entries)
    6. 2117488Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89703] (1 PDB entry)
    7. 2117491Species Norway rat (Rattus norvegicus), (a1-1) [TaxId:10116] [52871] (2 PDB entries)
    8. 2117498Species Schistosoma japonicum [TaxId:6182] [52878] (14 PDB entries)
      Uniprot P08515
  3. 2117514Class beta GST [81368] (4 species)
    1. 2117515Species Escherichia coli [TaxId:562] [52883] (3 PDB entries)
    2. 2117521Species Ochrobactrum anthropi [TaxId:529] [225311] (2 PDB entries)
    3. 2117524Species Proteus mirabilis [TaxId:584] [52884] (2 PDB entries)
    4. 2117530Species Sphingomonas paucimobilis [TaxId:13689] [52885] (1 PDB entry)
  4. 2117535Class delta GST [81366] (6 species)
    formerly a part of class theta enzymes
    1. 2117536Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [102441] (1 PDB entry)
    2. 2117539Species Anopheles dirus [TaxId:7168] [224892] (2 PDB entries)
    3. 2117544Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [75234] (1 PDB entry)
    4. 2117551Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [75235] (1 PDB entry)
    5. 2117554Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [102439] (1 PDB entry)
    6. 2117556Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [102440] (1 PDB entry)
  5. 2117561Class mu GST [81359] (3 species)
    1. 2117562Species Chicken (Gallus gallus) [TaxId:9031] [52869] (2 PDB entries)
    2. 2117569Species Human (Homo sapiens) [TaxId:9606] [52867] (16 PDB entries)
      Uniprot P09488 ! Uniprot P28161
    3. 2117623Species Norway rat (Rattus norvegicus) [TaxId:10116] [52868] (16 PDB entries)
  6. 2117659Class omega GST [81363] (1 species)
  7. 2117662Class phi GST [81367] (3 species)
    1. 2117663Species Maize (Zea mays), type I [TaxId:4577] [52881] (2 PDB entries)
    2. 2117670Species Maize (Zea mays), type III [TaxId:4577] [52882] (1 PDB entry)
    3. 2117672Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [52880] (2 PDB entries)
  8. 2117676Class pi GST [81358] (4 species)
    1. 2117677Species Human (Homo sapiens) [TaxId:9606] [52864] (59 PDB entries)
    2. 2117792Species Mouse (Mus musculus) [TaxId:10090] [52866] (9 PDB entries)
    3. 2117814Species Onchocerca volvulus [TaxId:6282] [117595] (2 PDB entries)
      Uniprot P46427
    4. 2117821Species Pig (Sus scrofa) [TaxId:9823] [52865] (1 PDB entry)
  9. 2117824Class sigma GST [81362] (5 species)
    1. 2117825Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [82427] (1 PDB entry)
    2. 2117828Species Heligmosomoides polygyrus [TaxId:6339] [110608] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment
    3. 2117837Species Human (Homo sapiens) [TaxId:9606] [89705] (7 PDB entries)
      Uniprot O60760
      synonym: hematopoietic prostaglandin D synthase
    4. 2117864Species Norway rat (Rattus norvegicus) [TaxId:10116] [52875] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase
    5. 2117867Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [52876] (2 PDB entries)
  10. 2117870Class tau GST [81365] (2 species)
    1. 2117871Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [75236] (1 PDB entry)
    2. 2117875Species Rice (Oryza sativa) [TaxId:4530] [89706] (1 PDB entry)
  11. 2117880Class theta GST [81361] (1 species)
  12. 2117888Class zeta GST [81364] (2 species)
    1. 2117889Species Human (Homo sapiens) [TaxId:9606] [64058] (1 PDB entry)
      maleylacetoacetate isomerase
    2. 2117891Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [64059] (1 PDB entry)
  13. 2117893Glutaredoxin 2 [64060] (1 species)
    similar to class zeta enzymes
  14. 2117896GST-like domain of elongation factor 1-gamma [82428] (1 species)
  15. 2117899Hypothetical protein AGR_pAT_752p/Atu5508 [142361] (1 species)
    putative glutathione S-transferase
  16. 2117905Microsomal prostaglandin E synthase-2 [142363] (1 species)
  17. 2117915Pf GST [102442] (1 species)
    cannot be assigned to any of the known GST classes
  18. 2117929Yeast prion protein ure2p, nitrogen regulation fragment [52886] (1 species)
    similar to class phi enzymes
  19. 2117957automated matches [227019] (3 species)
    not a true protein
    1. 2117958Species Human (Homo sapiens) [TaxId:9606] [232826] (7 PDB entries)
    2. 2117968Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [225817] (3 PDB entries)
    3. 2275572Species Arabidopsis thaliana [TaxId:3702] [318873] (4 PDB entries)

More info for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

Timeline for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain: