SCOP 1.75: Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Lineage for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (5 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (6 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Proteins:

1. Protein-tyrosine phosphatase alpha [102420] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [102421] (1 PDB entry)

2. Protein-tyrosine phosphatase YopH, catalytic domain [100952] (1 species)

   • Species Yersinia enterocolitica [TaxId:630] [52812] (11 PDB entries)

3. RPTP Lar [52815] (1 species)
   duplication: tandem repeat of the phosphatase domain

   • Species Human (Homo sapiens) [TaxId:9606] [52816] (1 PDB entry)

4. SptP tyrosine phosphatase, catalytic domain [52813] (1 species)

   • Species Salmonella typhimurium [TaxId:90371] [52814] (2 PDB entries)

5. Tyrosine phosphatase [52806] (7 species)

   1. Species Human (Homo sapiens), 1B [TaxId:9606] [52807] (91 PDB entries)
      Uniprot P18031 2-300
      Uniprot P18031 1-298
      Uniprot P18031 2-299
      Uniprot P18031 2-300 ! Uniprot P18031 1-298 ! Uniprot P18031 2-299

   2. Species Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry)
      receptor protein tyrosine phosphatase mu, domain 1

   3. Species Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (2 PDB entries)

   4. Species Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)

   5. Species Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry)
      non-receptor type 2

   6. Species Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry)
      receptor protein tyrosine phosphatase alpha, domain 1

   7. Species Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry)

6. Tyrosine-protein phosphatase, non-receptor type 13 (PTPL1) [117581] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117582] (1 PDB entry)
     Uniprot Q12923 2170-2477 # structure of a PDZ domain (1361-1456) is also known ((50169))

More info for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Timeline for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases:

• Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases first appeared (with stable ids) in SCOP 1.55
  
• Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases appears in SCOP 1.73
  
• Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases appears in SCOPe 2.01
  
• Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases appears in the current release, SCOPe 2.08