Lineage for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 584246Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 584247Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (4 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 584295Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (6 proteins)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Proteins:

  1. 584296Protein-tyrosine phosphatase alpha [102420] (1 species)
  2. 584300Protein-tyrosine phosphatase YopH, catalytic domain [100952] (1 species)
  3. 584311RPTP Lar [52815] (1 species)
    duplication: tandem repeat of the phosphatase domain
  4. 584317SptP tyrosine phosphatase, catalytic domain [52813] (1 species)
  5. 584321Tyrosine phosphatase [52806] (7 species)
    1. 584322Species Human (Homo sapiens), 1B [TaxId:9606] [52807] (63 PDB entries)
    2. 584394Species Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry)
      receptor protein tyrosine phosphatase mu, domain 1
    3. 584397Species Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (2 PDB entries)
    4. 584400Species Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)
    5. 584403Species Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry)
      non-receptor type 2
    6. 584405Species Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry)
      receptor protein tyrosine phosphatase alpha, domain 1
    7. 584408Species Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry)
  6. 584410Tyrosine-protein phosphatase, non-receptor type 13 (PTPL1) [117581] (1 species)

More info for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Timeline for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases: