SCOPe 2.01: Family c.37.1.14: RNA helicase

Lineage for Family c.37.1.14: RNA helicase

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.14: RNA helicase [52724] (3 proteins)
   duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

Proteins:

1. Dengue virus helicase [142328] (1 species)

   • Species Dengue virus type 2 [TaxId:11060] [142329] (2 PDB entries)
     Uniprot Q91H74 1653-1957! Uniprot Q91H74 1958-2093

2. HCV helicase domain [52725] (1 species)

   • Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [52726] (6 PDB entries)

3. YFV helicase domain [142330] (1 species)

   • Species Yellow fever virus [TaxId:11089] [142331] (1 PDB entry)
     Uniprot P19901 1669-1842! Uniprot P19901 1843-2107

More info for Family c.37.1.14: RNA helicase

Timeline for Family c.37.1.14: RNA helicase:

• Family c.37.1.14: RNA helicase first appeared (with stable ids) in SCOP 1.55
  
• Family c.37.1.14: RNA helicase appears in SCOP 1.75
  
• Family c.37.1.14: RNA helicase appears in SCOPe 2.02
  
• Family c.37.1.14: RNA helicase appears in the current release, SCOPe 2.08