Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily) 3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes |
Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families) division into families based on beta-sheet topologies |
Family c.37.1.8: G proteins [52592] (79 proteins) core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest |
ADP-ribosylation factor [52614] (16 species) |
Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry) |
Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [142220] (2 PDB entries) |
Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (12 PDB entries) Uniprot P32889 |
Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry) Uniprot P18085 3-177 |
Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries) |
Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries) |
Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry) Uniprot Q9Y689 2-178 |
Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry) Uniprot Q96KC2 6-173 |
Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry) Uniprot Q96BM9 18-181 |
Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry) Uniprot Q9NVJ2 18-182 |
Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries) |
Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (5 PDB entries) |
Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (2 PDB entries) |
Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries) |
Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry) |
CDC42 [52619] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [52620] (28 PDB entries) |
Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry) |
Centaurin gamma 1, G domain [142249] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142250] (1 PDB entry) Uniprot Q99490 402-576 |
cH-p21 Ras protein [52593] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52594] (109 PDB entries) Uniprot Q6P716 |
Chloroplast protein translocon GTPase Toc34 [69485] (1 species) |
Species Pea (Pisum sativum) [TaxId:3888] [69486] (1 PDB entry) |
di-Ras1 [142277] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142278] (1 PDB entry) Uniprot O95057 4-176 |
di-Ras2 [142267] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142268] (1 PDB entry) Uniprot Q96HU8 6-176 |
Dynamin G domain [69488] (2 species) the family common core is decorated with large insertions |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry) Uniprot P21575 6-304 Dynamin-1 |
Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries) |
Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (2 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries) Uniprot P32324 |
Species Homo sapiens [TaxId:9606] [268001] (1 PDB entry) |
Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species) eukaryotic and archaeal homologue of EF-Tu |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries) |
Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries) Uniprot P35021 |
Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species) has internal nucleotide exchange factor built in as an insertion subdomain |
Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries) residues 160-252 comprise insertion subdomain |
Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries) Uniprot Q5SI76 1-267 TTHA1498 |
Elongation factor SelB, N-terminal domain [117537] (1 species) |
Species Methanococcus maripaludis [TaxId:39152] [117538] (3 PDB entries) Uniprot Q8J307 |
Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species) |
Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries) Uniprot P49410 56-452 |
Species Escherichia coli [TaxId:562] [52627] (10 PDB entries) Uniprot P02990 |
Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries) |
Species Thermus thermophilus [TaxId:274] [52629] (4 PDB entries) |
Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species) |
Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [110536] (3 PDB entries) Uniprot O74718 |
GTP-binding protein engB [142257] (1 species) |
Species Pyrococcus horikoshii [TaxId:53953] [142258] (1 PDB entry) Uniprot O57939 28-211 PH0200 |
GTP-binding protein GEM [142289] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142290] (2 PDB entries) Uniprot P55040 73-244 |
GTP-binding protein PH0525 [142251] (1 species) Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain |
Species Pyrococcus horikoshii [TaxId:53953] [142252] (1 PDB entry) Uniprot O58261 1-319 |
GTP-binding protein RheB [142275] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [142276] (3 PDB entries) Uniprot Q15382 3-169 |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [255395] (1 PDB entry) |
GTPase Era, N-terminal domain [52637] (3 species) |
Species Escherichia coli K-12 [TaxId:83333] [224886] (1 PDB entry) |
Species Escherichia coli [TaxId:562] [52638] (2 PDB entries) |
Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries) Uniprot Q5SM23 |
GTPase Ytp1 [110544] (1 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110545] (2 PDB entries) Uniprot P01123 |
Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species) includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211) |
Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry) |
Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries) |
Species Sulfolobus solfataricus [TaxId:2287] [142227] (10 PDB entries) Uniprot Q980A5 2-206 |
Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species) |
Species Methanobacterium thermoautotrophicum [TaxId:145262] [52636] (3 PDB entries) |
Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52640] (2 PDB entries) |
Interferon-inducible GTPase [110546] (1 species) G domain is inserted in all-alpha domain |
Species Mouse (Mus musculus) [TaxId:10090] [110547] (5 PDB entries) Uniprot Q9QZ85 # all-alpha domain (14-68,252-415) |
Obg GTP-binding protein middle domain [82408] (2 species) |
Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry) |
Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry) TT1381 |
Probable GTPase Der, N-terminal and middle domains [82406] (1 species) member of EngA subfamily of GTPases; contains two G domains |
Species Thermotoga maritima [TaxId:2336] [82407] (1 PDB entry) |
Probable GTPase EngB [89667] (2 species) |
Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries) Uniprot P38424 |
Species Escherichia coli [TaxId:562] [89668] (1 PDB entry) |
Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species) circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain |
Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry) Uniprot O34530 |
Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry) Uniprot Q9X242 # TM1717 |
Probable GTPase YlqF [89669] (1 species) naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain |
Species Bacillus subtilis [TaxId:1423] [89670] (1 PDB entry) |
Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species) |
Species Escherichia coli [TaxId:562] [102367] (1 PDB entry) |
r-Ras [142273] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142274] (1 PDB entry) Uniprot P10301 24-196 |
r-Ras2 [142281] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142282] (1 PDB entry) Uniprot P62070 10-180 |
Rab-22a [142253] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [142254] (2 PDB entries) Uniprot P35285 2-167! Uniprot P35285 2-168 |
Rab-33b [142279] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [142280] (2 PDB entries) Uniprot O35963 32-196 |
Rab-related protein Sec4 [52607] (1 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52608] (3 PDB entries) |
Rab-related protein ypt7p [75199] (1 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75200] (2 PDB entries) |
Rab11a [102362] (2 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries) |
Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries) |
Rab11b [142237] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142238] (2 PDB entries) Uniprot Q15907 7-181 |
Rab14 [142271] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142272] (1 PDB entry) Uniprot P61106 7-174 |
Rab18 [142233] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142234] (1 PDB entry) Uniprot Q9NP72 2-178 |
Rab1a [142241] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142242] (3 PDB entries) Uniprot P62820 7-175 |
Rab21 [142285] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142286] (3 PDB entries) Uniprot Q9UL25 16-182 |
Rab23 [142231] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [142232] (1 PDB entry) Uniprot P35288 8-171 |
Rab26 [142259] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142260] (1 PDB entry) Uniprot Q9ULW5 58-227 |
Rab27b [142263] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry) Uniprot O00194 4-189 |
Species Mouse (Mus musculus) [TaxId:10090] [256388] (1 PDB entry) |
Rab2a [142265] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142266] (1 PDB entry) Uniprot P61019 2-170 |
Rab2b [142287] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142288] (1 PDB entry) Uniprot Q8WUD1 4-176 |
Rab30 [142239] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142240] (1 PDB entry) Uniprot Q15771 5-175 |
Rab31 [142235] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142236] (1 PDB entry) Uniprot Q13636 3-167 |
Rab3a [52601] (1 species) |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [52602] (2 PDB entries) |
Rab4a [142247] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142248] (3 PDB entries) Uniprot P20338 2-172! Uniprot P20338 4-172! Uniprot P20338 4-184 |
Rab5a [82399] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [82400] (12 PDB entries) Uniprot P20339 18-182 |
Rab5c [52603] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [52604] (3 PDB entries) |
Rab6 [52605] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry) Uniprot P20340 13-176 |
Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry) |
Rab7 [110540] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries) Uniprot P51149 7-182 |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries) Uniprot P09527 |
Rab8a [142293] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [254870] (4 PDB entries) |
Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry) Uniprot P55258 3-175 |
Rab9a [110537] (3 species) |
Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry) Uniprot P24408 |
Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry) Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175) |
Species Mouse (Mus musculus) [TaxId:10090] [142229] (2 PDB entries) Uniprot Q9R0M6 4-175 |
Rac [52595] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52596] (17 PDB entries) |
Rac3 [142255] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142256] (1 PDB entry) Uniprot P60763 3-177 |
Rad [142295] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142296] (1 PDB entry) Uniprot P55042 91-258 |
Ran [52609] (2 species) |
Species Dog (Canis familiaris) [TaxId:9615] [52610] (11 PDB entries) Uniprot P62825 |
Species Human (Homo sapiens) [TaxId:9606] [52611] (40 PDB entries) |
Rap1A [52597] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52598] (2 PDB entries) |
Rap2a [52599] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52600] (3 PDB entries) |
Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142292] (1 PDB entry) Uniprot Q96A58 5-172 |
Ras-related protein M-Ras (XRas) [142283] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [142284] (1 PDB entry) Uniprot O08989 10-178 |
Ras-related protein RalA [89662] (2 species) |
Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries) Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322) |
Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries) |
RhoA [52612] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [52613] (23 PDB entries) Uniprot P61586 2-181 |
RhoB [142243] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142244] (1 PDB entry) Uniprot P62745 4-185 |
RhoC [142245] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142246] (3 PDB entries) Uniprot P08134 1-179 |
RhoE (RND3) [75201] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [75202] (2 PDB entries) |
RhoQ [142261] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142262] (1 PDB entry) Uniprot P17081 1-185 |
SAR1 [69483] (3 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries) |
Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry) Uniprot Q9NR31 13-198 |
Signal recognition particle receptor beta-subunit [89664] (2 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry) |
Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries) Uniprot P47758 63-269 |
Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species) |
Species Pseudomonas syringae pv. tomato [TaxId:323] [142270] (1 PDB entry) Uniprot Q87WW1 16-237 |
Transducin (alpha subunit) [52623] (4 species) common fold is interrupted with an all-alpha domain |
Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries) Uniprot P04896 39-388 |
Species Human (Homo sapiens) [TaxId:9606] [159560] (7 PDB entries) |
Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries) Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372 |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries) Uniprot P10824 |
TrmE GTPase domain [117535] (1 species) |
Species Thermotoga maritima [TaxId:2336] [117536] (2 PDB entries) Uniprot Q9WYA4 |
YchF GTP-binding protein N-terminal domain [82410] (2 species) Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain |
Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry) |
Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry) HI0393 |
Ypt51 [52621] (1 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52622] (1 PDB entry) |
automated matches [190047] (27 species) not a true protein |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (9 PDB entries) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (4 PDB entries) |
Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries) |
Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry) |
Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry) |
Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (1 PDB entry) |
Species Entamoeba histolytica [TaxId:294381] [273048] (1 PDB entry) |
Species Escherichia coli K-12 [TaxId:83333] [256110] (3 PDB entries) |
Species Escherichia coli [TaxId:316385] [272313] (3 PDB entries) |
Species Escherichia coli [TaxId:469008] [187117] (4 PDB entries) |
Species Escherichia coli [TaxId:83333] [272301] (1 PDB entry) |
Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [186768] (145 PDB entries) |
Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry) |
Species Mouse (Mus musculus) [TaxId:10090] [186896] (12 PDB entries) |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (6 PDB entries) |
Species Oryza sativa [TaxId:39947] [259129] (1 PDB entry) |
Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry) |
Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry) |
Species Pyrococcus horikoshii [TaxId:70601] [187582] (1 PDB entry) |
Species Saccharomyces cerevisiae [TaxId:764097] [261066] (1 PDB entry) |
Species Sulfolobus solfataricus [TaxId:2287] [255781] (3 PDB entries) |
Species Sulfolobus solfataricus [TaxId:273057] [256083] (11 PDB entries) |
Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries) |
Species Thermus aquaticus [TaxId:271] [254880] (1 PDB entry) |
Species Thermus thermophilus HB8 [TaxId:300852] [255082] (2 PDB entries) |
Species Thermus thermophilus [TaxId:274] [256283] (6 PDB entries) |
Timeline for Family c.37.1.8: G proteins: