Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1845072Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 1845073Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families) (S)
    division into families based on beta-sheet topologies
  5. 1845934Family c.37.1.8: G proteins [52592] (79 protein domains)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Protein Domains:

  1. 1845935ADP-ribosylation factor [52614] (16 species)
    1. 1845936Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 1845938Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 1845941Species Human (Homo sapiens) [TaxId:9606] [142220] (2 PDB entries)
    4. 1845945Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (12 PDB entries)
      Uniprot P32889
    5. 1845967Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 1845970Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 1845977Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)
    8. 1845986Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 1845988Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 1845990Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 1845992Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 1845994Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries)
    13. 1846001Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (5 PDB entries)
    14. 1846009Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (2 PDB entries)
    15. 1846013Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    16. 1846017Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
  2. 1846020CDC42 [52619] (2 species)
    1. 1846021Species Human (Homo sapiens) [TaxId:9606] [52620] (28 PDB entries)
    2. 1846062Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry)
  3. 1846065Centaurin gamma 1, G domain [142249] (1 species)
  4. 1846068cH-p21 Ras protein [52593] (1 species)
  5. 1846197Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 1846202di-Ras1 [142277] (1 species)
  7. 1846208di-Ras2 [142267] (1 species)
  8. 1846211Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 1846212Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 1846214Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 1846217Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (2 species)
    1. 1846218Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries)
      Uniprot P32324
    2. 1846244Species Homo sapiens [TaxId:9606] [268001] (1 PDB entry)
  10. 1846246Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 1846247Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 1846254Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 1846259Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 1846260Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 1846271Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 1846274Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 1846288Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 1846289Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 1846295Species Escherichia coli [TaxId:562] [52627] (10 PDB entries)
      Uniprot P02990
    3. 1846312Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 1846321Species Thermus thermophilus [TaxId:274] [52629] (4 PDB entries)
  14. 1846330Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 1846335GTP-binding protein engB [142257] (1 species)
  16. 1846338GTP-binding protein GEM [142289] (1 species)
  17. 1846343GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. 1846346GTP-binding protein RheB [142275] (2 species)
    1. 1846347Species Human (Homo sapiens) [TaxId:9606] [142276] (3 PDB entries)
      Uniprot Q15382 3-169
    2. 1846352Species Norway rat (Rattus norvegicus) [TaxId:10116] [255395] (1 PDB entry)
  19. 1846354GTPase Era, N-terminal domain [52637] (3 species)
    1. 1846355Species Escherichia coli K-12 [TaxId:83333] [224886] (1 PDB entry)
    2. 1846358Species Escherichia coli [TaxId:562] [52638] (2 PDB entries)
    3. 1846362Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries)
      Uniprot Q5SM23
  20. 1846365GTPase Ytp1 [110544] (1 species)
  21. 1846369Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 1846370Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 1846372Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 1846378Species Sulfolobus solfataricus [TaxId:2287] [142227] (10 PDB entries)
      Uniprot Q980A5 2-206
  22. 1846396Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 1846401Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 1846405Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 1846415Obg GTP-binding protein middle domain [82408] (2 species)
    1. 1846416Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 1846419Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 1846421Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 1846425Probable GTPase EngB [89667] (2 species)
    1. 1846426Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 1846432Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 1846435Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 1846436Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 1846438Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  29. 1846442Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 1846445Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 1846448r-Ras [142273] (1 species)
  32. 1846451r-Ras2 [142281] (1 species)
  33. 1846454Rab-22a [142253] (1 species)
  34. 1846458Rab-33b [142279] (1 species)
  35. 1846462Rab-related protein Sec4 [52607] (1 species)
  36. 1846471Rab-related protein ypt7p [75199] (1 species)
  37. 1846475Rab11a [102362] (2 species)
    1. 1846476Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries)
    2. 1846482Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries)
  38. 1846489Rab11b [142237] (1 species)
  39. 1846493Rab14 [142271] (1 species)
  40. 1846496Rab18 [142233] (1 species)
  41. 1846499Rab1a [142241] (1 species)
  42. 1846507Rab21 [142285] (1 species)
  43. 1846512Rab23 [142231] (1 species)
  44. 1846515Rab26 [142259] (1 species)
  45. 1846518Rab27b [142263] (2 species)
    1. 1846519Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry)
      Uniprot O00194 4-189
    2. 1846522Species Mouse (Mus musculus) [TaxId:10090] [256388] (1 PDB entry)
  46. 1846525Rab2a [142265] (1 species)
  47. 1846528Rab2b [142287] (1 species)
  48. 1846531Rab30 [142239] (1 species)
  49. 1846534Rab31 [142235] (1 species)
  50. 1846537Rab3a [52601] (1 species)
  51. 1846541Rab4a [142247] (1 species)
  52. 1846547Rab5a [82399] (1 species)
  53. 1846569Rab5c [52603] (1 species)
  54. 1846575Rab6 [52605] (2 species)
    1. 1846576Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 1846578Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 1846580Rab7 [110540] (2 species)
    1. 1846581Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 1846587Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  56. 1846598Rab8a [142293] (2 species)
    1. 1846599Species Human (Homo sapiens) [TaxId:9606] [254870] (4 PDB entries)
    2. 1846614Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry)
      Uniprot P55258 3-175
  57. 1846617Rab9a [110537] (3 species)
    1. 1846618Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 1846621Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 1846624Species Mouse (Mus musculus) [TaxId:10090] [142229] (2 PDB entries)
      Uniprot Q9R0M6 4-175
  58. 1846627Rac [52595] (1 species)
  59. 1846656Rac3 [142255] (1 species)
  60. 1846659Rad [142295] (1 species)
  61. 1846662Ran [52609] (2 species)
    1. 1846663Species Dog (Canis familiaris) [TaxId:9615] [52610] (11 PDB entries)
      Uniprot P62825
    2. 1846687Species Human (Homo sapiens) [TaxId:9606] [52611] (40 PDB entries)
  62. 1846752Rap1A [52597] (1 species)
  63. 1846756Rap2a [52599] (1 species)
  64. 1846762Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 1846765Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 1846768Ras-related protein RalA [89662] (2 species)
    1. 1846769Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 1846776Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 1846785RhoA [52612] (1 species)
  68. 1846827RhoB [142243] (1 species)
  69. 1846830RhoC [142245] (1 species)
  70. 1846837RhoE (RND3) [75201] (1 species)
  71. 1846842RhoQ [142261] (1 species)
  72. 1846846SAR1 [69483] (3 species)
    1. 1846847Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 1846851Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 1846854Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  73. 1846857Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 1846858Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 1846860Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  74. 1846863Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 1846866Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 1846867Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries)
      Uniprot P04896 39-388
    2. 1846891Species Human (Homo sapiens) [TaxId:9606] [159560] (7 PDB entries)
    3. 1846906Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 1846915Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries)
      Uniprot P10824
  76. 1846942TrmE GTPase domain [117535] (1 species)
  77. 1846946YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 1846947Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 1846949Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 1846952Ypt51 [52621] (1 species)
  79. 1846955automated matches [190047] (27 species)
    not a true protein
    1. 1846956Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (9 PDB entries)
    2. 1846974Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (4 PDB entries)
    3. 1846981Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    4. 1846986Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    5. 1846988Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry)
    6. 1846991Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (1 PDB entry)
    7. 1846994Species Entamoeba histolytica [TaxId:294381] [273048] (1 PDB entry)
    8. 1846997Species Escherichia coli K-12 [TaxId:83333] [256110] (3 PDB entries)
    9. 1847003Species Escherichia coli [TaxId:316385] [272313] (3 PDB entries)
    10. 1847010Species Escherichia coli [TaxId:469008] [187117] (4 PDB entries)
    11. 1847022Species Escherichia coli [TaxId:83333] [272301] (1 PDB entry)
    12. 1847025Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    13. 1847028Species Human (Homo sapiens) [TaxId:9606] [186768] (145 PDB entries)
    14. 1847278Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    15. 1847280Species Mouse (Mus musculus) [TaxId:10090] [186896] (12 PDB entries)
    16. 1847298Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (6 PDB entries)
    17. 1847308Species Oryza sativa [TaxId:39947] [259129] (1 PDB entry)
    18. 1847310Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    19. 1847319Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    20. 1847325Species Pyrococcus horikoshii [TaxId:70601] [187582] (1 PDB entry)
    21. 1847328Species Saccharomyces cerevisiae [TaxId:764097] [261066] (1 PDB entry)
    22. 1847330Species Sulfolobus solfataricus [TaxId:2287] [255781] (3 PDB entries)
    23. 1847337Species Sulfolobus solfataricus [TaxId:273057] [256083] (11 PDB entries)
    24. 1847349Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries)
    25. 1847363Species Thermus aquaticus [TaxId:271] [254880] (1 PDB entry)
    26. 1847367Species Thermus thermophilus HB8 [TaxId:300852] [255082] (2 PDB entries)
    27. 1847370Species Thermus thermophilus [TaxId:274] [256283] (6 PDB entries)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: