Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.03
  2. 1336837Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1362078Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 1362079Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families) (S)
    division into families based on beta-sheet topologies
  5. 1362829Family c.37.1.8: G proteins [52592] (79 proteins)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

  1. 1362830ADP-ribosylation factor [52614] (16 species)
    1. 1362831Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 1362833Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 1362836Species Human (Homo sapiens) [TaxId:9606] [142220] (1 PDB entry)
      Uniprot P84085 6-179
    4. 1362838Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (12 PDB entries)
      Uniprot P32889
    5. 1362860Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 1362863Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 1362870Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)
    8. 1362879Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 1362881Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 1362883Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 1362885Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 1362887Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries)
    13. 1362894Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (4 PDB entries)
    14. 1362900Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (2 PDB entries)
    15. 1362904Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    16. 1362908Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
  2. 1362911CDC42 [52619] (2 species)
    1. 1362912Species Human (Homo sapiens) [TaxId:9606] [52620] (26 PDB entries)
    2. 1362951Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry)
  3. 1362954Centaurin gamma 1, G domain [142249] (1 species)
  4. 1362957cH-p21 Ras protein [52593] (1 species)
  5. 1363074Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 1363079di-Ras1 [142277] (1 species)
  7. 1363085di-Ras2 [142267] (1 species)
  8. 1363088Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 1363089Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 1363091Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 1363094Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)
  10. 1363128Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 1363129Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 1363136Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 1363141Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 1363142Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 1363153Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 1363156Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 1363170Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 1363171Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 1363177Species Escherichia coli [TaxId:562] [52627] (9 PDB entries)
      Uniprot P02990
    3. 1363192Species Thermus aquaticus [TaxId:271] [52628] (5 PDB entries)
    4. 1363204Species Thermus thermophilus [TaxId:274] [52629] (6 PDB entries)
  14. 1363215Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 1363220GTP-binding protein engB [142257] (1 species)
  16. 1363223GTP-binding protein GEM [142289] (1 species)
  17. 1363228GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. GTP-binding protein RheB [142275] (1 species)
  19. 1363237GTPase Era, N-terminal domain [52637] (3 species)
    1. 1363238Species Escherichia coli [TaxId:562] [52638] (2 PDB entries)
    2. 1363242Species Escherichia coli [TaxId:83333] [224886] (1 PDB entry)
    3. 1363245Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries)
      Uniprot Q5SM23
  20. 1363248GTPase Ytp1 [110544] (1 species)
  21. 1363252Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 1363253Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 1363255Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 1363261Species Sulfolobus solfataricus [TaxId:2287] [142227] (5 PDB entries)
      Uniprot Q980A5 2-206
  22. 1363268Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 1363273Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 1363277Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 1363287Obg GTP-binding protein middle domain [82408] (2 species)
    1. 1363288Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 1363291Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 1363293Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 1363297Probable GTPase EngB [89667] (2 species)
    1. 1363298Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 1363304Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 1363307Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 1363308Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 1363310Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  29. 1363314Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 1363317Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 1363320r-Ras [142273] (1 species)
  32. 1363323r-Ras2 [142281] (1 species)
  33. 1363326Rab-22a [142253] (1 species)
  34. 1363330Rab-33b [142279] (1 species)
  35. 1363334Rab-related protein Sec4 [52607] (1 species)
  36. 1363344Rab-related protein ypt7p [75199] (1 species)
  37. 1363348Rab11a [102362] (2 species)
    1. 1363349Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries)
    2. 1363355Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries)
  38. 1363362Rab11b [142237] (1 species)
  39. 1363366Rab14 [142271] (1 species)
  40. 1363369Rab18 [142233] (1 species)
  41. 1363372Rab1a [142241] (1 species)
  42. 1363377Rab21 [142285] (1 species)
  43. 1363382Rab23 [142231] (1 species)
  44. 1363385Rab26 [142259] (1 species)
  45. 1363388Rab27b [142263] (1 species)
  46. 1363392Rab2a [142265] (1 species)
  47. 1363395Rab2b [142287] (1 species)
  48. 1363398Rab30 [142239] (1 species)
  49. 1363401Rab31 [142235] (1 species)
  50. 1363404Rab3a [52601] (1 species)
  51. 1363408Rab4a [142247] (1 species)
  52. 1363414Rab5a [82399] (1 species)
  53. 1363436Rab5c [52603] (1 species)
  54. 1363442Rab6 [52605] (2 species)
    1. 1363443Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 1363445Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 1363447Rab7 [110540] (2 species)
    1. 1363448Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 1363454Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  56. 1363465Rab8a [142293] (1 species)
  57. 1363469Rab9a [110537] (3 species)
    1. 1363470Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 1363473Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 1363476Species Mouse (Mus musculus) [TaxId:10090] [142229] (1 PDB entry)
      Uniprot Q9R0M6 4-175
  58. 1363478Rac [52595] (1 species)
  59. 1363507Rac3 [142255] (1 species)
  60. 1363510Rad [142295] (1 species)
  61. 1363513Ran [52609] (2 species)
    1. 1363514Species Dog (Canis familiaris) [TaxId:9615] [52610] (9 PDB entries)
      Uniprot P62825
    2. 1363532Species Human (Homo sapiens) [TaxId:9606] [52611] (28 PDB entries)
  62. 1363576Rap1A [52597] (1 species)
  63. 1363580Rap2a [52599] (1 species)
  64. 1363586Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 1363589Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 1363592Ras-related protein RalA [89662] (2 species)
    1. 1363593Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 1363600Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 1363609RhoA [52612] (1 species)
  68. 1363646RhoB [142243] (1 species)
  69. 1363649RhoC [142245] (1 species)
  70. 1363656RhoE (RND3) [75201] (1 species)
  71. 1363661RhoQ [142261] (1 species)
  72. 1363665SAR1 [69483] (3 species)
    1. 1363666Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 1363670Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 1363673Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  73. 1363676Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 1363677Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 1363679Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  74. 1363682Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 1363685Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 1363686Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries)
      Uniprot P04896 39-388
    2. 1363710Species Human (Homo sapiens) [TaxId:9606] [159560] (7 PDB entries)
    3. 1363725Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 1363734Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries)
      Uniprot P10824
  76. 1363761TrmE GTPase domain [117535] (1 species)
  77. 1363765YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 1363766Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 1363768Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 1363771Ypt51 [52621] (1 species)
  79. 1363774automated matches [190047] (16 species)
    not a true protein
    1. 1363775Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (3 PDB entries)
    2. 1363781Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (2 PDB entries)
    3. 1363785Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    4. 1363790Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    5. 1363792Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry)
    6. 1363795Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (1 PDB entry)
    7. 1363798Species Escherichia coli [TaxId:469008] [187117] (3 PDB entries)
    8. 1363809Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    9. 1363812Species Human (Homo sapiens) [TaxId:9606] [186768] (113 PDB entries)
    10. 1364026Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    11. 1364028Species Mouse (Mus musculus) [TaxId:10090] [186896] (13 PDB entries)
    12. 1364053Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (2 PDB entries)
    13. 1364058Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    14. 1364067Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    15. 1364073Species Pyrococcus horikoshii [TaxId:70601] [187582] (1 PDB entry)
    16. 1364076Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: