Lineage for Family c.37.1.8: G proteins

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 695085Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 695086Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families) (S)
    division into families based on beta-sheet topologies
  5. 695634Family c.37.1.8: G proteins [52592] (78 proteins)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

  1. 695635ADP-ribosylation factor [52614] (14 species)
    1. 695636Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 695638Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 695641Species Human (Homo sapiens) [TaxId:9606] [142220] (1 PDB entry)
    4. 695643Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (9 PDB entries)
    5. 695661Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
    6. 695664Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 695671Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)
    8. 695680Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (2 PDB entries)
    9. 695684Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
    10. 695686Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
    11. 695688Species Human(Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
    12. 695690Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)
    13. 695694Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (1 PDB entry)
    14. 695696Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
  2. 695700CDC42 [52619] (1 species)
  3. 695730Centaurin gamma 1, G domain [142249] (1 species)
  4. 695733cH-p21 Ras protein [52593] (1 species)
  5. 695799Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 695804di-Ras1 [142277] (1 species)
  7. 695810di-Ras2 [142267] (1 species)
  8. 695814Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 695815Species Rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Dynamin-1
    2. 695817Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 695820Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)
  10. 695845Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 695846Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
    2. 695851Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
  11. 695858Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 695859Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 695870Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (1 PDB entry)
      TTHA1498
  12. 695872Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 695886Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 695887Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
    2. 695893Species Escherichia coli [TaxId:562] [52627] (9 PDB entries)
    3. 695908Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 695917Species Thermus thermophilus [TaxId:274] [52629] (7 PDB entries)
  14. 695931Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 695936GTP-binding protein engB [142257] (1 species)
  16. 695941GTP-binding protein GEM [142289] (1 species)
  17. 695944GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. 695947GTP-binding protein RheB [142275] (1 species)
  19. 695952GTPase Era, N-terminal domain [52637] (2 species)
    1. 695953Species Escherichia coli [TaxId:562] [52638] (3 PDB entries)
    2. 695958Species Thermus thermophilus [TaxId:274] [117533] (1 PDB entry)
  20. 695960GTPase Ytp1 [110544] (1 species)
  21. 695964Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83
    1. 695965Species Archaeon Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 695967Species Archaeon Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 695973Species Sulfolobus solfataricus [TaxId:2287] [142227] (1 PDB entry)
  22. 695975Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 695980Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 695984Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 695994Obg GTP-binding protein middle domain [82408] (2 species)
    1. 695995Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 695998Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 696000Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 696004Probable GTPase EngB [89667] (2 species)
    1. 696005Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
    2. 696011Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 696014Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 696015Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
    2. 696017Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
  29. 696021Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 696024Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 696037r-Ras [142273] (1 species)
  32. 696040r-Ras2 [142281] (1 species)
  33. 696044Rab-22a [142253] (1 species)
  34. 696048Rab-33b [142279] (1 species)
  35. 696051Rab-related protein Sec4 [52607] (1 species)
  36. 696061Rab-related protein ypt7p [75199] (1 species)
  37. 696065Rab11a [102362] (1 species)
  38. 696081Rab11b [142237] (1 species)
  39. 696085Rab14 [142271] (1 species)
  40. 696089Rab18 [142233] (1 species)
  41. 696092Rab1a [142241] (1 species)
  42. 696095Rab21 [142285] (1 species)
  43. 696106Rab23 [142231] (1 species)
  44. 696110Rab26 [142259] (1 species)
  45. 696113Rab27b [142263] (1 species)
  46. 696117Rab2a [142265] (1 species)
  47. 696123Rab2b [142287] (1 species)
  48. 696126Rab30 [142239] (1 species)
  49. 696129Rab31 [142235] (1 species)
  50. 696132Rab3a [52601] (1 species)
  51. 696136Rab4a [142247] (1 species)
  52. 696143Rab5a [82399] (1 species)
  53. 696163Rab5c [52603] (1 species)
  54. 696169Rab6 [52605] (2 species)
    1. 696170Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
    2. 696172Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 696174Rab7 [110540] (2 species)
    1. 696175Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
    2. 696181Species Rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
  56. 696192Rab8a [142293] (1 species)
  57. 696196Rab9a [110537] (3 species)
    1. 696197Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
    2. 696200Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
    3. 696203Species Mouse (Mus musculus) [TaxId:10090] [142229] (1 PDB entry)
  58. 696205Rac [52595] (1 species)
  59. 696233Rac3 [142255] (1 species)
  60. 696237Rad [142295] (1 species)
  61. 696241Ran [52609] (2 species)
    1. 696242Species Dog (Canis familiaris) [TaxId:9615] [52610] (6 PDB entries)
    2. 696256Species Human (Homo sapiens) [TaxId:9606] [52611] (6 PDB entries)
  62. 696272Rap1A [52597] (1 species)
  63. 696276Rap2a [52599] (1 species)
  64. 696282Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 696285Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 696289Ras-related protein RalA [89662] (2 species)
    1. 696290Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
    2. 696297Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 696306RhoA [52612] (1 species)
  68. 696329RhoB [142243] (1 species)
  69. 696332RhoC [142245] (1 species)
  70. 696336RhoE (RND3) [75201] (1 species)
  71. 696341RhoQ [142261] (1 species)
  72. 696345SAR1 [69483] (3 species)
    1. 696346Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (1 PDB entry)
    2. 696349Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (2 PDB entries)
    3. 696354Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
  73. 696357Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 696358Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 696360Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
  74. 696363Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 696366Transducin (alpha subunit) [52623] (3 species)
    common fold is interrupted with an all-alpha domain
    1. 696367Species Cow (Bos taurus) [TaxId:9913] [52624] (15 PDB entries)
    2. 696388Species Mouse (Mus musculus) [TaxId:10090] [142225] (3 PDB entries)
    3. 696393Species Rat (Rattus norvegicus) [TaxId:10116] [52625] (26 PDB entries)
  76. 696431TrmE GTPase domain [117535] (1 species)
  77. 696435YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 696436Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 696438Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 696441Ypt51 [52621] (1 species)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: