SCOP 1.73: Family c.37.1.8: G proteins

Lineage for Family c.37.1.8: G proteins

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (78 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

1. ADP-ribosylation factor [52614] (14 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)

   3. Species Human (Homo sapiens) [TaxId:9606] [142220] (1 PDB entry)

   4. Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (9 PDB entries)

   5. Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)

   6. Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)

   7. Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)

   8. Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (2 PDB entries)

   9. Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)

   10. Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)

   11. Species Human(Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)

   12. Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)

   13. Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (1 PDB entry)

   14. Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)

2. CDC42 [52619] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52620] (18 PDB entries)

3. Centaurin gamma 1, G domain [142249] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [142250] (1 PDB entry)

4. cH-p21 Ras protein [52593] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52594] (52 PDB entries)

5. Chloroplast protein translocon GTPase Toc34 [69485] (1 species)

   • Species Garden pea (Pisum sativum) [TaxId:3888] [69486] (1 PDB entry)

6. di-Ras1 [142277] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [142278] (1 PDB entry)

7. di-Ras2 [142267] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [142268] (1 PDB entry)

8. Dynamin G domain [69488] (2 species)
   the family common core is decorated with large insertions

   1. Species Rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Dynamin-1

   2. Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)

9. Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries)

10. Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu

    1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)

    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)

11. Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain

    1. Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
       residues 160-252 comprise insertion subdomain

    2. Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (1 PDB entry)
       TTHA1498

12. Elongation factor SelB, N-terminal domain [117537] (1 species)

    • Species Methanococcus maripaludis [TaxId:39152] [117538] (3 PDB entries)

13. Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)

    1. Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)

    2. Species Escherichia coli [TaxId:562] [52627] (9 PDB entries)

    3. Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)

    4. Species Thermus thermophilus [TaxId:274] [52629] (7 PDB entries)

14. Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)

    • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [110536] (3 PDB entries)

15. GTP-binding protein engB [142257] (1 species)

    • Species Pyrococcus horikoshii [TaxId:53953] [142258] (1 PDB entry)
      PH0200

16. GTP-binding protein GEM [142289] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142290] (1 PDB entry)

17. GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain

    • Species Pyrococcus horikoshii [TaxId:53953] [142252] (1 PDB entry)

18. GTP-binding protein RheB [142275] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142276] (3 PDB entries)

19. GTPase Era, N-terminal domain [52637] (2 species)

    1. Species Escherichia coli [TaxId:562] [52638] (3 PDB entries)

    2. Species Thermus thermophilus [TaxId:274] [117533] (1 PDB entry)

20. GTPase Ytp1 [110544] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110545] (2 PDB entries)

21. Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83

    1. Species Archaeon Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)

    2. Species Archaeon Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)

    3. Species Sulfolobus solfataricus [TaxId:2287] [142227] (1 PDB entry)

22. Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)

    • Species Archaeon Methanobacterium thermoautotrophicum [TaxId:145262] [52636] (3 PDB entries)

23. Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52640] (2 PDB entries)

24. Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain

    • Species Mouse (Mus musculus) [TaxId:10090] [110547] (5 PDB entries)

25. Obg GTP-binding protein middle domain [82408] (2 species)

    1. Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)

    2. Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
       TT1381

26. Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains

    • Species Thermotoga maritima [TaxId:2336] [82407] (1 PDB entry)

27. Probable GTPase EngB [89667] (2 species)

    1. Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)

    2. Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)

28. Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain

    1. Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)

    2. Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)

29. Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain

    • Species Bacillus subtilis [TaxId:1423] [89670] (1 PDB entry)

30. Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)

    • Species Escherichia coli [TaxId:562] [102367] (4 PDB entries)

31. r-Ras [142273] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142274] (1 PDB entry)

32. r-Ras2 [142281] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142282] (1 PDB entry)

33. Rab-22a [142253] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [142254] (2 PDB entries)

34. Rab-33b [142279] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [142280] (1 PDB entry)

35. Rab-related protein Sec4 [52607] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52608] (4 PDB entries)

36. Rab-related protein ypt7p [75199] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75200] (2 PDB entries)

37. Rab11a [102362] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [102363] (9 PDB entries)

38. Rab11b [142237] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142238] (2 PDB entries)

39. Rab14 [142271] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142272] (2 PDB entries)

40. Rab18 [142233] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142234] (1 PDB entry)

41. Rab1a [142241] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142242] (1 PDB entry)

42. Rab21 [142285] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142286] (4 PDB entries)

43. Rab23 [142231] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [142232] (2 PDB entries)

44. Rab26 [142259] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142260] (1 PDB entry)

45. Rab27b [142263] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry)

46. Rab2a [142265] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142266] (1 PDB entry)

47. Rab2b [142287] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142288] (1 PDB entry)

48. Rab30 [142239] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142240] (1 PDB entry)

49. Rab31 [142235] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142236] (1 PDB entry)

50. Rab3a [52601] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [52602] (2 PDB entries)

51. Rab4a [142247] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142248] (4 PDB entries)

52. Rab5a [82399] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82400] (11 PDB entries)

53. Rab5c [52603] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [52604] (3 PDB entries)

54. Rab6 [52605] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)

    2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)

55. Rab7 [110540] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)

56. Rab8a [142293] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry)

57. Rab9a [110537] (3 species)

    1. Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)

    3. Species Mouse (Mus musculus) [TaxId:10090] [142229] (1 PDB entry)

58. Rac [52595] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52596] (16 PDB entries)

59. Rac3 [142255] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142256] (1 PDB entry)

60. Rad [142295] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142296] (1 PDB entry)

61. Ran [52609] (2 species)

    1. Species Dog (Canis familiaris) [TaxId:9615] [52610] (6 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [52611] (6 PDB entries)

62. Rap1A [52597] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52598] (2 PDB entries)

63. Rap2a [52599] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52600] (3 PDB entries)

64. Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142292] (1 PDB entry)

65. Ras-related protein M-Ras (XRas) [142283] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [142284] (2 PDB entries)

66. Ras-related protein RalA [89662] (2 species)

    1. Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)

67. RhoA [52612] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52613] (12 PDB entries)

68. RhoB [142243] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142244] (1 PDB entry)

69. RhoC [142245] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142246] (1 PDB entry)

70. RhoE (RND3) [75201] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [75202] (2 PDB entries)

71. RhoQ [142261] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142262] (1 PDB entry)

72. SAR1 [69483] (3 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (1 PDB entry)

    2. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (2 PDB entries)

    3. Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)

73. Signal recognition particle receptor beta-subunit [89664] (2 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)

74. Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)

    • Species Pseudomonas syringae pv. tomato [TaxId:323] [142270] (1 PDB entry)

75. Transducin (alpha subunit) [52623] (3 species)
    common fold is interrupted with an all-alpha domain

    1. Species Cow (Bos taurus) [TaxId:9913] [52624] (15 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [142225] (3 PDB entries)

    3. Species Rat (Rattus norvegicus) [TaxId:10116] [52625] (26 PDB entries)

76. TrmE GTPase domain [117535] (1 species)

    • Species Thermotoga maritima [TaxId:2336] [117536] (2 PDB entries)

77. YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain

    1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)

    2. Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
       HI0393

78. Ypt51 [52621] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52622] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins:

• Family c.37.1.8: G proteins first appeared (with stable ids) in SCOP 1.55
  
• Family c.37.1.8: G proteins appears in SCOP 1.71
  
• Family c.37.1.8: G proteins appears in SCOP 1.75
  
• Family c.37.1.8: G proteins appears in the current release, SCOPe 2.08