SCOP 1.67: Family c.37.1.8: G proteins

Lineage for Family c.37.1.8: G proteins

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (22 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (37 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

1. ADP-ribosylation factor [52614] (8 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)

   3. Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (7 PDB entries)

   4. Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (2 PDB entries)

   5. Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)

   6. Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)

   7. Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (1 PDB entry)

   8. Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)

2. CDC42 [52619] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52620] (16 PDB entries)

3. cH-p21 Ras protein [52593] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52594] (46 PDB entries)

4. Chloroplast protein translocon GTPase Toc34 [69485] (1 species)

   • Species Garden pea (Pisum sativum) [TaxId:3888] [69486] (1 PDB entry)

5. Dynamin G domain [69488] (1 species)
   the family common core is decorated with large insertions

   • Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)

6. Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (2 PDB entries)

7. Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
   eukaryotic and archaeal homologue of EF-Tu

   1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69487] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (4 PDB entries)

8. Elongation factor G (EF-G), N-terminal (G) domain [52633] (1 species)
   has internal nucleotide exchange factor built in as an insertion subdomain

   • Species Thermus thermophilus [TaxId:274] [52634] (6 PDB entries)
     residues 160-252 comprise insertion subdomain

9. Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)

   1. Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [52627] (6 PDB entries)

   3. Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)

   4. Species Thermus thermophilus [TaxId:274] [52629] (3 PDB entries)

10. GTPase Era, N-terminal domain [52637] (1 species)

    • Species Escherichia coli [TaxId:562] [52638] (1 PDB entry)

11. Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (2 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83

    1. Species Archaeon Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)

    2. Species Archaeon Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)

12. Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)

    • Species Archaeon Methanobacterium thermoautotrophicum [TaxId:145262] [52636] (3 PDB entries)

13. Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52640] (2 PDB entries)

14. Obg GTP-binding protein middle domain [82408] (2 species)

    1. Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)

    2. Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
       TT1381

15. Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains

    • Species Thermotoga maritima [TaxId:243274] [82407] (1 PDB entry)

16. Probable GTPase EngB [89667] (1 species)

    • Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)

17. Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain

    • Species Bacillus subtilis [TaxId:1423] [89670] (1 PDB entry)

18. Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)

    • Species Escherichia coli [TaxId:562] [102367] (1 PDB entry)

19. Rab-related protein Sec4 [52607] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52608] (2 PDB entries)

20. Rab-related protein ypt7p [75199] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75200] (2 PDB entries)

21. Rab11a [102362] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [102363] (2 PDB entries)

22. Rab3a [52601] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [52602] (2 PDB entries)

23. Rab5a [82399] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82400] (9 PDB entries)

24. Rab5c [52603] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [52604] (1 PDB entry)

25. Rab6 [52605] (1 species)

    • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)

26. Rac [52595] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52596] (12 PDB entries)

27. Ran [52609] (2 species)

    1. Species Dog (Canis familiaris) [TaxId:9615] [52610] (5 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [52611] (6 PDB entries)

28. Rap1A [52597] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52598] (2 PDB entries)

29. Rap2a [52599] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52600] (3 PDB entries)

30. Ras-related protein RalA [89662] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89663] (1 PDB entry)

31. RhoA [52612] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52613] (10 PDB entries)

32. RhoE (RND3) [75201] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [75202] (2 PDB entries)

33. SAR1 [69483] (2 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (1 PDB entry)

    2. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)

34. Signal recognition particle receptor beta-subunit [89664] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)

35. Transducin (alpha subunit) [52623] (2 species)
    common fold is interrupted with an all-alpha domain

    1. Species Cow (Bos taurus) [TaxId:9913] [52624] (11 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [52625] (18 PDB entries)

36. YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain

    1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)

    2. Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
       HI0393

37. Ypt51 [52621] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52622] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins:

• Family c.37.1.8: G proteins first appeared (with stable ids) in SCOP 1.55
  
• Family c.37.1.8: G proteins appears in SCOP 1.65
  
• Family c.37.1.8: G proteins appears in SCOP 1.69
  
• Family c.37.1.8: G proteins appears in the current release, SCOPe 2.08