SCOP 1.63: Family c.37.1.8: G proteins

Lineage for Family c.37.1.8: G proteins

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.37: P-loop containing nucleotide triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleotide triphosphate hydrolases [52540] (20 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (31 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

1. ADP-ribosylation factor [52614] (7 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)

   3. Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (1 PDB entry)

   4. Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (2 PDB entries)

   5. Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)

   6. Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (1 PDB entry)

   7. Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)

2. CDC42 [52619] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52620] (15 PDB entries)

3. cH-p21 Ras protein [52593] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52594] (38 PDB entries)

4. Chloroplast protein translocon GTPase Toc34 [69485] (1 species)

   • Species Garden pea (Pisum sativum) [TaxId:3888] [69486] (1 PDB entry)

5. Dynamin G domain [69488] (1 species)
   the family common core is decorated with large insertions

   • Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)

6. Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (2 PDB entries)

7. Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
   eukaryotic and archaeal homologue of EF-Tu

   1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69487] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (4 PDB entries)

8. Elongation factor G (EF-G), N-terminal (G) domain [52633] (1 species)
   has internal nucleotide exchange factor built in as an insertion subdomain

   • Species Thermus thermophilus [TaxId:274] [52634] (5 PDB entries)
     residues 160-252 comprise insertion subdomain

9. Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)

   1. Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [52627] (6 PDB entries)

   3. Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)

   4. Species Thermus thermophilus [TaxId:274] [52629] (3 PDB entries)

10. GTPase Era, N-terminal domain [52637] (1 species)

    • Species Escherichia coli [TaxId:562] [52638] (1 PDB entry)

11. Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (1 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83

    • Species Archaeon Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)

12. Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)

    • Species Archaeon Methanobacterium thermoautotrophicum [TaxId:145262] [52636] (3 PDB entries)

13. Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52640] (2 PDB entries)

14. Obg GTP-binding protein C-terminal domain [82408] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)

15. Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains

    • Species Thermotoga maritima [TaxId:243274] [82407] (1 PDB entry)

16. Rab-related protein Sec4 [52607] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52608] (2 PDB entries)

17. Rab-related protein ypt7p [75199] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75200] (2 PDB entries)

18. Rab3a [52601] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [52602] (2 PDB entries)

19. Rab5a [82399] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82400] (8 PDB entries)

20. Rab5c [52603] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [52604] (1 PDB entry)

21. Rab6 [52605] (1 species)

    • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)

22. Rac [52595] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52596] (10 PDB entries)

23. Ran [52609] (2 species)

    1. Species Dog (Canis familiaris) [TaxId:9615] [52610] (5 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [52611] (6 PDB entries)

24. Rap1A [52597] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52598] (2 PDB entries)

25. Rap2a [52599] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52600] (3 PDB entries)

26. RhoA [52612] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52613] (7 PDB entries)

27. RhoE (RND3) [75201] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [75202] (2 PDB entries)

28. SAR1 [69483] (2 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (1 PDB entry)

    2. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)

29. Transducin (alpha subunit) [52623] (2 species)
    common fold is interrupted with an all-alpha domain

    1. Species Cow (Bos taurus) [TaxId:9913] [52624] (11 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [52625] (18 PDB entries)

30. YchF GTP-binding protein N-terminal domain [82410] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain

    • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)

31. Ypt51 [52621] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52622] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins:

• Family c.37.1.8: G proteins first appeared (with stable ids) in SCOP 1.55
  
• Family c.37.1.8: G proteins appears in SCOP 1.61
  
• Family c.37.1.8: G proteins appears in SCOP 1.65
  
• Family c.37.1.8: G proteins appears in the current release, SCOPe 2.08