SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies

Families:

  1. 2109205c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 protein domains)
    parallel beta-sheet of 5 strands, order 23145
  2. 2109815c.37.1.2: Shikimate kinase (AroK) [52566] (2 protein domains)
    similar to the nucleotide/nucleoside kinases but acts on different substrate
    automatically mapped to Pfam PF01202
  3. 2109861c.37.1.3: Chloramphenicol phosphotransferase [52569] (1 protein)
    similar to the nucleotide/nucleoside kinases but acts on different substrate
    automatically mapped to Pfam PF07931
  4. 2109870c.37.1.4: Adenosine-5'phosphosulfate kinase (APS kinase) [52572] (2 protein domains)
    automatically mapped to Pfam PF01583
  5. 2109901c.37.1.5: PAPS sulfotransferase [52575] (15 protein domains)
    Pfam PF00685
    similar to the nucleotide/nucleoside kinases but transfer sulphate group
  6. 2110026c.37.1.6: Phosphoribulokinase/pantothenate kinase [52584] (6 protein domains)
  7. 2110089c.37.1.7: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52589] (1 protein)
    automatically mapped to Pfam PF01591
  8. 2110099c.37.1.8: G proteins [52592] (79 protein domains)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest
  9. 2111568c.37.1.9: Motor proteins [52641] (5 protein domains)
  10. 2111791c.37.1.10: Nitrogenase iron protein-like [52652] (16 protein domains)
    core: parallel beta-sheet of 7 strands; order 3241567
  11. 2112131c.37.1.11: RecA protein-like (ATPase-domain) [52670] (21 protein domains)
    core: mixed beta-sheet of 8 strands, order 32451678; strand 7 is antiparallel to the rest
  12. 2112785c.37.1.12: ABC transporter ATPase domain-like [52686] (25 protein domains)
    there are two additional subdomains inserted into the central core that has a RecA-like topology
  13. 2113070c.37.1.14: RNA helicase [52724] (4 protein domains)
    duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension
  14. 2113175c.37.1.15: ATP sulfurylase C-terminal domain [64011] (1 protein)
  15. 2113198c.37.1.16: Helicase-like "domain" of reverse gyrase [69496] (1 protein)
  16. 2113207c.37.1.17: Gluconate kinase [75195] (1 protein)
    similar to the nucleotide/nucleoside kinases
    automatically mapped to Pfam PF01202
  17. 2113222c.37.1.18: YjeE-like [75213] (1 protein)
    mixed beta-sheet; order 234156(0), strands 2 and 6 are antiparallel to the rest
    automatically mapped to Pfam PF02367
  18. 2113231c.37.1.19: Tandem AAA-ATPase domain [81268] (24 protein domains)
    duplication: tandem repeat of two RecA-like (AAA) domains
  19. 2113456c.37.1.20: Extended AAA-ATPase domain [81269] (29 protein domains)
    fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain
  20. 2113807c.37.1.21: Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82395] (2 protein domains)
    similar to the nucleotide/nucleoside kinases; extra N- and C-terminal structures
  21. 2113816c.37.1.22: Bacterial cell division inhibitor SulA [89678] (1 protein)
    homologous to RecA but lacks its P-loop motif; the fold is C-terminally truncated; 5-stranded parallel beta-sheet, order: 15423
  22. 2113825c.37.1.23: DNA helicase UvsW [102396] (1 protein)
    contains extra N-terminal alpha+beta subdomain
  23. 2113830c.37.1.24: Type II thymidine kinase [117558] (2 protein domains)
    N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)
  24. 2113879c.37.1.25: Atu3015-like [142332] (2 protein domains)
    unknown function; similar to the nucleotide/nucleoside kinases
  25. 2113886c.37.1.26: Adenosine phosphateisopentenyltransferase (IPT)-like [310655] (1 protein)
  26. 2113903c.37.1.0: automated matches [191323] (1 protein)
    not a true family

More info for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases

Timeline for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases: