SCOP 1.63: Protein: Transketolase (TK), PP and Pyr modules

Lineage for Protein: Transketolase (TK), PP and Pyr modules

Root: SCOP 1.63
Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families)

both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules

Family c.36.1.2: TK-like THDP-binding domains [52528] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Transketolase (TK), PP and Pyr modules [52529] (2 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52530] (7 PDB entries)
1. Domains for 1ay0:
  1. Domain d1ay0a1: 1ay0 A:3-337 [31823]
    Other proteins in same PDB: d1ay0a3, d1ay0b3
  2. Domain d1ay0a2: 1ay0 A:338-534 [31824]
    Other proteins in same PDB: d1ay0a3, d1ay0b3
  3. Domain d1ay0b1: 1ay0 B:3-337 [31825]
    Other proteins in same PDB: d1ay0a3, d1ay0b3
  4. Domain d1ay0b2: 1ay0 B:338-534 [31826]
    Other proteins in same PDB: d1ay0a3, d1ay0b3
    complexed with ca, tpp; mutant
2. Domains for 1gpu:
  1. Domain d1gpua1: 1gpu A:3-337 [65454]
    Other proteins in same PDB: d1gpua3, d1gpub3
  2. Domain d1gpua2: 1gpu A:338-534 [65455]
    Other proteins in same PDB: d1gpua3, d1gpub3
  3. Domain d1gpub1: 1gpu B:3-337 [65457]
    Other proteins in same PDB: d1gpua3, d1gpub3
  4. Domain d1gpub2: 1gpu B:338-534 [65458]
    Other proteins in same PDB: d1gpua3, d1gpub3
    complexed with ca, thd
3. Domains for 1ngs:
  1. Domain d1ngsa1: 1ngs A:3-337 [31819]
    Other proteins in same PDB: d1ngsa3, d1ngsb3
  2. Domain d1ngsa2: 1ngs A:338-534 [31820]
    Other proteins in same PDB: d1ngsa3, d1ngsb3
  3. Domain d1ngsb1: 1ngs B:3-337 [31821]
    Other proteins in same PDB: d1ngsa3, d1ngsb3
  4. Domain d1ngsb2: 1ngs B:338-534 [31822]
    Other proteins in same PDB: d1ngsa3, d1ngsb3
    complexed with ca, e4p, tpp
4. Domains for 1tka:
  1. Domain d1tkaa1: 1tka A:3-337 [31815]
    Other proteins in same PDB: d1tkaa3, d1tkab3
  2. Domain d1tkaa2: 1tka A:338-534 [31816]
    Other proteins in same PDB: d1tkaa3, d1tkab3
  3. Domain d1tkab1: 1tka B:3-337 [31817]
    Other proteins in same PDB: d1tkaa3, d1tkab3
  4. Domain d1tkab2: 1tka B:338-534 [31818]
    Other proteins in same PDB: d1tkaa3, d1tkab3
    complexed with ca, n3t
5. Domains for 1tkb:
  1. Domain d1tkba1: 1tkb A:3-337 [31807]
    Other proteins in same PDB: d1tkba3, d1tkbb3
  2. Domain d1tkba2: 1tkb A:338-534 [31808]
    Other proteins in same PDB: d1tkba3, d1tkbb3
  3. Domain d1tkbb1: 1tkb B:3-337 [31809]
    Other proteins in same PDB: d1tkba3, d1tkbb3
  4. Domain d1tkbb2: 1tkb B:338-534 [31810]
    Other proteins in same PDB: d1tkba3, d1tkbb3
    complexed with ca, n1t
6. Domains for 1tkc:
  1. Domain d1tkca1: 1tkc A:3-337 [31811]
    Other proteins in same PDB: d1tkca3, d1tkcb3
  2. Domain d1tkca2: 1tkc A:338-534 [31812]
    Other proteins in same PDB: d1tkca3, d1tkcb3
  3. Domain d1tkcb1: 1tkc B:3-337 [31813]
    Other proteins in same PDB: d1tkca3, d1tkcb3
  4. Domain d1tkcb2: 1tkc B:338-534 [31814]
    Other proteins in same PDB: d1tkca3, d1tkcb3
    complexed with ca, m6t
7. Domains for 1trk:
  1. Domain d1trka1: 1trk A:3-337 [31803]
    Other proteins in same PDB: d1trka3, d1trkb3
  2. Domain d1trka2: 1trk A:338-534 [31804]
    Other proteins in same PDB: d1trka3, d1trkb3
  3. Domain d1trkb1: 1trk B:3-337 [31805]
    Other proteins in same PDB: d1trka3, d1trkb3
  4. Domain d1trkb2: 1trk B:338-534 [31806]
    Other proteins in same PDB: d1trka3, d1trkb3
    complexed with ca, tpp
Maize (Zea mays) [TaxId:4577] [82392] (1 PDB entry)
- Domains for 1itz:
  1. Domain d1itza1: 1itz A:10-347 [76797]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
  2. Domain d1itza2: 1itz A:348-539 [76798]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
  3. Domain d1itzb1: 1itz B:10-347 [76800]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
  4. Domain d1itzb2: 1itz B:348-539 [76801]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
  5. Domain d1itzc1: 1itz C:10-347 [76803]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
  6. Domain d1itzc2: 1itz C:348-539 [76804]
    Other proteins in same PDB: d1itza3, d1itzb3, d1itzc3
    complexed with mg, tpp

More info for Protein Transketolase (TK), PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains

Timeline for Protein Transketolase (TK), PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains:

Protein Transketolase (TK), PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains first appeared (with stable ids) in SCOP 1.55, called Protein Transketolase, TK from c.36.1.2: Transketolase, TK
Protein Transketolase (TK), PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains was called Protein Transketolase, TK from c.36.1.2: TK-like in SCOP 1.61
Protein Transketolase (TK), PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains does not appear in SCOP 1.65