SCOP 1.63: Family c.36.1.2: TK-like THDP-binding domains

Lineage for Family c.36.1.2: TK-like THDP-binding domains

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families)
   both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
   conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules

5. Family c.36.1.2: TK-like THDP-binding domains [52528] (2 proteins)
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Proteins:

1. Pyruvate dehydrogenase E1 component, PP and Pyr modules [75185] (1 species)
   E1A and E1B fused together in a single-chain protein

   • Species Escherichia coli [TaxId:562] [75186] (1 PDB entry)

2. Transketolase (TK), PP and Pyr modules [52529] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52530] (7 PDB entries)

   2. Species Maize (Zea mays) [TaxId:4577] [82392] (1 PDB entry)

More info for Family c.36.1.2: TK-like THDP-binding domains

Timeline for Family c.36.1.2: TK-like THDP-binding domains:

• Family c.36.1.2: TK-like THDP-binding domains first appeared (with stable ids) in SCOP 1.55, called Family c.36.1.2: Transketolase, TK
  
• Family c.36.1.2: TK-like THDP-binding domains was called Family c.36.1.2: TK-like in SCOP 1.61
  
• Family c.36.1.2: TK-like THDP-binding domains does not appear in SCOP 1.65