SCOP 1.75: Protein: Transhydrogenase domain III (dIII)

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families)
binds cofactor molecules in the opposite direction than classical Rossmann fold
Family c.31.1.4: Transhydrogenase domain III (dIII) [52484] (1 protein)
binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode
Protein Transhydrogenase domain III (dIII) [52485] (3 species)

Cow (Bos taurus) [TaxId:9913] [52487] (1 PDB entry)
- Domain for 1d4o:
  - Domain d1d4oa_: 1d4o A: [31748]
Human (Homo sapiens) [TaxId:9606] [52486] (3 PDB entries)
1. Domains for 1djl:
  1. Domain d1djla_: 1djl A: [31746]
  2. Domain d1djlb_: 1djl B: [31747]
    complexed with gol, nap, so4
2. Domains for 1pt9:
  1. Domain d1pt9a_: 1pt9 A: [95097]
  2. Domain d1pt9b_: 1pt9 B: [95098]
    complexed with gol, so4, tap
3. Domains for 1u31:
  1. Domain d1u31a1: 1u31 A:23-204 [119491]
    automatically matched to d1djla_
    complexed with gol, nap, so4
  2. Domain d1u31b1: 1u31 B:23-204 [119492]
    automatically matched to d1djla_
    complexed with gol, nap, so4

Domain for 1e3t:
- Domain d1e3ta_: 1e3t A: [31749]
  complexed with nap
Domain for 1hzz:
- Domain d1hzzc_: 1hzz C: [61474]
  Other proteins in same PDB: d1hzza1, d1hzza2, d1hzzb1, d1hzzb2
  complexed with dI component
  complexed with nad, nap
Domain for 1nm5:
- Domain d1nm5c_: 1nm5 C: [91972]
  Other proteins in same PDB: d1nm5a1, d1nm5a2, d1nm5b1, d1nm5b2
  complexed with dI component
  complexed with gol, nad, nap; mutant
Domains for 1pno:
1. Domain d1pnoa_: 1pno A: [94953]
2. Domain d1pnob_: 1pno B: [94954]
  complexed with nap
Domains for 1pnq:
1. Domain d1pnqa_: 1pnq A: [94955]
2. Domain d1pnqb_: 1pnq B: [94956]
  complexed with ndp
Domain for 1ptj:
- Domain d1ptjc_: 1ptj C: [95103]
  Other proteins in same PDB: d1ptja1, d1ptja2, d1ptjb1, d1ptjb2
  complexed with dI component
  complexed with gol, nap, snd
Domain for 1u28:
- Domain d1u28c1: 1u28 C:33-203 [119472]
  Other proteins in same PDB: d1u28a1, d1u28a2, d1u28b1, d1u28b2
  automatically matched to d1pnoa_
  complexed with gol, nad, nap
Domain for 1u2d:
- Domain d1u2dc1: 1u2d C:33-203 [119479]
  Other proteins in same PDB: d1u2da1, d1u2da2, d1u2db1, d1u2db2
  automatically matched to d1pnoa_
  complexed with gol, nad, ndp
Domain for 1u2g:
- Domain d1u2gc1: 1u2g C:33-203 [119484]
  Other proteins in same PDB: d1u2ga1, d1u2ga2, d1u2gb1, d1u2gb2
  automatically matched to d1pnoa_
  complexed with apr, gol, ndp

Domains for 1xlt:

Domain d1xltc1: 1xlt C:291-464 [122126]
Other proteins in same PDB: d1xlta1, d1xlta2, d1xltb1, d1xltb2, d1xltd1, d1xltd2, d1xlte1, d1xlte2, d1xltg1, d1xltg2, d1xlth1, d1xlth2
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc

Domain d1xltf1: 1xlt F:292-464 [122131]
Other proteins in same PDB: d1xlta1, d1xlta2, d1xltb1, d1xltb2, d1xltd1, d1xltd2, d1xlte1, d1xlte2, d1xltg1, d1xltg2, d1xlth1, d1xlth2
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc

Domain d1xlti1: 1xlt I:292-464 [122136]
Other proteins in same PDB: d1xlta1, d1xlta2, d1xltb1, d1xltb2, d1xltd1, d1xltd2, d1xlte1, d1xlte2, d1xltg1, d1xltg2, d1xlth1, d1xlth2
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc

Domain for 2fr8:
- Domain d2fr8c1: 2fr8 C:33-203 [133977]
  Other proteins in same PDB: d2fr8a1, d2fr8a2, d2fr8b1, d2fr8b2
  automatically matched to d1pnoa_
  complexed with nad, nap; mutant
Domain for 2frd:
- Domain d2frdc1: 2frd C:33-203 [133984]
  Other proteins in same PDB: d2frda1, d2frda2, d2frdb1, d2frdb2
  automatically matched to d1pnoa_
  complexed with nad, nap; mutant
Domain for 2fsv:
- Domain d2fsvc1: 2fsv C:30-203 [134041]
  Other proteins in same PDB: d2fsva1, d2fsva2, d2fsvb1, d2fsvb2
  complexed with gol, nad, nap; mutant
Domain for 2oo5:
- Domain d2oo5c1: 2oo5 C:33-203 [139166]
  Other proteins in same PDB: d2oo5a1, d2oo5a2, d2oo5b1, d2oo5b2
  automatically matched to d1pnoa_
  complexed with nap, so4, txd
Domain for 2oor:
- Domain d2oorc1: 2oor C:33-202 [139175]
  Other proteins in same PDB: d2oora1, d2oora2, d2oorb1, d2oorb2
  automatically matched to d1pnoa_
  complexed with gol, nad, txp

Timeline for Protein Transhydrogenase domain III (dIII) from c.31.1.4: Transhydrogenase domain III (dIII):

Protein Transhydrogenase domain III (dIII) from c.31.1.4: Transhydrogenase domain III (dIII) first appeared (with stable ids) in SCOP 1.55
Protein Transhydrogenase domain III (dIII) from c.31.1.4: Transhydrogenase domain III (dIII) appears in SCOP 1.73
Protein Transhydrogenase domain III (dIII) from c.31.1.4: Transhydrogenase domain III (dIII) appears in SCOPe 2.01
Protein Transhydrogenase domain III (dIII) from c.31.1.4: Transhydrogenase domain III (dIII) appears in the current release, SCOPe 2.08