Lineage for Protein: Pyruvate decarboxylase

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1843167Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. 1843168Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. 1843195Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (8 proteins)
    N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
  6. 1843359Protein Pyruvate decarboxylase [52478] (3 species)
    rudiment domain with a variant fold, lacks FAD-binding

Species:

  1. 1843360Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52480] (2 PDB entries)
    1. Domains for 1pvd:
      1. 1843361Domain d1pvda1: 1pvd A:182-360 [31737]
        Other proteins in same PDB: d1pvda2, d1pvda3, d1pvdb2, d1pvdb3
        complexed with mg, tpp
      2. 1843362Domain d1pvdb1: 1pvd B:182-360 [31738]
        Other proteins in same PDB: d1pvda2, d1pvda3, d1pvdb2, d1pvdb3
        complexed with mg, tpp
    2. Domains for 1qpb:
      1. 1843363Domain d1qpba1: 1qpb A:182-360 [31739]
        Other proteins in same PDB: d1qpba2, d1qpba3, d1qpbb2, d1qpbb3
        complexed with mg, pym, tpp
      2. 1843364Domain d1qpbb1: 1qpb B:182-360 [31740]
        Other proteins in same PDB: d1qpba2, d1qpba3, d1qpbb2, d1qpbb3
        complexed with mg, pym, tpp
  2. 1843365Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [52479] (1 PDB entry)
  3. 1843368Zymomonas mobilis [TaxId:542] [52481] (1 PDB entry)

More info for Protein Pyruvate decarboxylase from c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Timeline for Protein Pyruvate decarboxylase from c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain: