Lineage for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (8 proteins)
    N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Proteins:

  1. Acetohydroxyacid synthase catalytic subunit [69463] (3 species)
    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69464] (8 PDB entries)
      Uniprot P07342 84-687
    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [314108] (3 PDB entries)
    3. Species Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142123] (12 PDB entries)
      Uniprot P17597 281-459
  2. Benzoylformate decarboxylase [52482] (1 species)
  3. Carboxyethylarginine synthase [102290] (1 species)
  4. Catabolic acetolactate synthase [102288] (1 species)
  5. Indole-3-pyruvate decarboxylase [89637] (1 species)
  6. Oxalyl-CoA decarboxylase [142124] (1 species)
  7. Pyruvate decarboxylase [52478] (3 species)
    rudiment domain with a variant fold, lacks FAD-binding
    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52480] (2 PDB entries)
    2. Species Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [52479] (1 PDB entry)
    3. Species Zymomonas mobilis [TaxId:542] [52481] (1 PDB entry)
  8. Pyruvate oxidase [52476] (2 species)
    binds FAD
    1. Species Aerococcus viridans [TaxId:1377] [142122] (2 PDB entries)
    2. Species Lactobacillus plantarum [TaxId:1590] [52477] (8 PDB entries)

More info for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Timeline for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain: