SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.26.2.1: N-type ATP pyrophosphatases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2105373Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
  4. 2106293Superfamily c.26.2: Adenine nucleotide alpha hydrolases-like [52402] (7 families) (S)
    share similar mode of ligand (Adenosine group) binding
    can be subdivided into two group with closer relationships within each group than between the groups; the first three families form one group whereas the last two families form the other group
  5. 2106294Family c.26.2.1: N-type ATP pyrophosphatases [52403] (9 protein domains)

Protein Domains:

  1. 2106295Argininosuccinate synthetase, N-terminal domain [69458] (3 species)
    1. 2106296Species Escherichia coli [TaxId:562] [69459] (4 PDB entries)
    2. 2106301Species Thermotoga maritima [TaxId:2336] [110493] (1 PDB entry)
      Uniprot Q9X2A1
    3. 2106306Species Thermus thermophilus [TaxId:274] [75167] (7 PDB entries)
  2. 2106335Asparagine synthetase B, C-terminal domain [52408] (1 species)
  3. 2106341beta-Lactam synthetase [69456] (2 species)
    Asparagine synthetase B homologue
    1. 2106342Species Pectobacterium carotovorum [TaxId:554] [102263] (2 PDB entries)
      carbapenam synthetase CarA
    2. 2106351Species Streptomyces clavuligerus [TaxId:1901] [69457] (5 PDB entries)
  4. 2106362GMP synthetase, central domain [52404] (2 species)
    1. 2106363Species Escherichia coli [TaxId:562] [52405] (1 PDB entry)
    2. 2106368Species Thermus thermophilus HB8 [TaxId:300852] [255716] (2 PDB entries)
  5. 2106377Hypothetical protein PH1257 [142085] (1 species)
    probable orthologue of PF0828
  6. 2106380NH3-dependent NAD+-synthetase [52406] (4 species)
    1. 2106381Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188002] (3 PDB entries)
    2. 2106390Species Bacillus subtilis [TaxId:1423] [52407] (7 PDB entries)
    3. 2106405Species Escherichia coli [TaxId:562] [142083] (1 PDB entry)
      Uniprot P18843 2-275
    4. 2106407Species Helicobacter pylori [TaxId:210] [142084] (1 PDB entry)
      Uniprot O25096 3-257
  7. 2106409Putative N-type ATP pyrophosphatase PF0828 [102264] (1 species)
  8. 2106418Queuosine biosynthesis protein QueC [159496] (1 species)
  9. 2106421automated matches [190257] (3 species)
    not a true protein
    1. 2106422Species Helicobacter pylori [TaxId:210] [188123] (2 PDB entries)
    2. 2106425Species Pyrococcus horikoshii [TaxId:53953] [187044] (1 PDB entry)
    3. 2106429Species Salmonella typhimurium [TaxId:90371] [188917] (1 PDB entry)

More info for Family c.26.2.1: N-type ATP pyrophosphatases

Timeline for Family c.26.2.1: N-type ATP pyrophosphatases: