Lineage for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 482378Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
  4. 482379Superfamily c.26.1: Nucleotidylyl transferase [52374] (5 families) (S)
  5. 482380Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (12 proteins)
    contains a conserved all-alpha subdomain at the C-terminal extension

Proteins:

  1. 482381Arginyl-tRNA synthetase (ArgRS) [52392] (2 species)
    1. 482382Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52393] (3 PDB entries)
    2. 482386Species Thermus thermophilus [TaxId:274] [69454] (1 PDB entry)
  2. 482388Class I lysyl-tRNA synthetase [75159] (1 species)
    similar domain organization to GluRS
  3. 482392Cysteinyl-tRNA synthetase (CysRS) [75161] (1 species)
  4. 482398Glutaminyl-tRNA synthetase (GlnRS) [52380] (1 species)
  5. 482413Glutamyl-Q tRNA-Asp synthetase YadB [102257] (1 species)
    truncated GluRS and GlnRS homologue lacking the anticodon-binding domain; glutamylates the modified base queuosine (Q) of tRNA-Asp
  6. 482416Glutamyl-tRNA synthetase (GluRS) [52382] (1 species)
    Catalytic domain is very similar to that of GlnRS
  7. 482427Isoleucyl-tRNA synthetase (IleRS) [52387] (2 species)
    1. 482428Species Staphylococcus aureus [TaxId:1280] [52389] (3 PDB entries)
    2. 482432Species Thermus thermophilus [TaxId:274] [52388] (3 PDB entries)
  8. 482436Leucyl-tRNA synthetase (LeuRS) [82356] (1 species)
    • 482437Species Thermus thermophilus [TaxId:274] [82357] (3 PDB entries)
      contains a non-conserved insertion (residues 581-633) that forms a separate subdomain; possible rudiment Zn finger
  9. 482441Methionyl-tRNA synthetase (MetRS) [52384] (3 species)
    1. 482442Species Escherichia coli [TaxId:562] [52386] (9 PDB entries)
    2. 482452Species Pyrococcus abyssi [TaxId:29292] [110490] (1 PDB entry)
    3. 482454Species Thermus thermophilus [TaxId:274] [52385] (1 PDB entry)
  10. 482456Tryptophanyl-tRNA synthetase (TrpRS) [52378] (2 species)
    overall structure is similar to TyrRS
    1. 482457Species Bacillus stearothermophilus [TaxId:1422] [52379] (8 PDB entries)
    2. 482481Species Human (Homo sapiens) [TaxId:9606] [102256] (4 PDB entries)
  11. 482489Tyrosyl-tRNA synthetase (TyrRS) [52376] (5 species)
    1. 482490Species Archaeon Methanococcus jannaschii [TaxId:2190] [89611] (1 PDB entry)
    2. 482492Species Bacillus stearothermophilus, nca 1503 [TaxId:1422] [52377] (7 PDB entries)
    3. 482501Species Human (Homo sapiens) [TaxId:9606] [82355] (2 PDB entries)
    4. 482504Species Staphylococcus aureus [TaxId:1280] [69453] (4 PDB entries)
    5. 482509Species Thermus thermophilus [TaxId:274] [82354] (2 PDB entries)
  12. 482513Valyl-tRNA synthetase (ValRS) [52390] (1 species)

More info for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Timeline for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain: