SCOP 1.65: Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Lineage for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
   core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.26.1: Nucleotidylyl transferase [52374] (5 families)

5. Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (11 proteins)
   contains a conserved all-alpha subdomain at the C-terminal extension

Proteins:

1. Arginyl-tRNA synthetase (ArgRS) [52392] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52393] (3 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [69454] (1 PDB entry)

2. Class I lysyl-tRNA synthetase [75159] (1 species)
   similar domain organisation to GluRS

   • Species Archaeon Pyrococcus horikoshii [TaxId:53953] [75160] (1 PDB entry)

3. Cysteinyl-tRNA synthetase (CysRS) [75161] (1 species)

   • Species Escherichia coli [TaxId:562] [75162] (2 PDB entries)

4. Glutaminyl-tRNA synthetase (GlnRS) [52380] (1 species)

   • Species Escherichia coli [TaxId:562] [52381] (13 PDB entries)

5. Glutamyl-tRNA synthetase (GluRS) [52382] (1 species)
   Catalytic domain is very similar to that of GlnRS

   • Species Thermus thermophilus [TaxId:274] [52383] (6 PDB entries)

6. Isoleucyl-tRNA synthetase (IleRS) [52387] (2 species)

   1. Species Staphylococcus aureus [TaxId:1280] [52389] (3 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [52388] (3 PDB entries)

7. Leucyl-tRNA synthetase (LeuRS) [82356] (1 species)

   • Species Thermus thermophilus [TaxId:274] [82357] (3 PDB entries)
     contains a non-conserved insertion (residues 581-633) that forms a separate subdomain; possible rudiment Zn finger

8. Methionyl-tRNA synthetase (MetRS) [52384] (2 species)

   1. Species Escherichia coli [TaxId:562] [52386] (2 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [52385] (1 PDB entry)

9. Tryptophanyl-tRNA synthetase (TrpRS) [52378] (1 species)
   overall structure is similar to TyrRS

   • Species Bacillus stearothermophilus [TaxId:1422] [52379] (8 PDB entries)

10. Tyrosyl-tRNA synthetase (TyrRS) [52376] (5 species)

    1. Species Archaeon Methanococcus jannaschii [TaxId:2190] [89611] (1 PDB entry)

    2. Species Bacillus stearothermophilus, nca 1503 [TaxId:1422] [52377] (7 PDB entries)

    3. Species Human (Homo sapiens) [TaxId:9606] [82355] (1 PDB entry)

    4. Species Staphylococcus aureus [TaxId:1280] [69453] (4 PDB entries)

    5. Species Thermus thermophilus [TaxId:274] [82354] (2 PDB entries)

11. Valyl-tRNA synthetase (ValRS) [52390] (1 species)

    • Species Thermus thermophilus [TaxId:274] [52391] (3 PDB entries)

More info for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Timeline for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain:

• Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain appears in SCOP 1.63
  
• Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain appears in SCOP 1.67
  
• Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain appears in the current release, SCOPe 2.08