SCOPe 2.07: Family c.23.16.1: Class I glutamine amidotransferases (GAT)

Lineage for Family c.23.16.1: Class I glutamine amidotransferases (GAT)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
   3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

4. Superfamily c.23.16: Class I glutamine amidotransferase-like [52317] (10 families)
   conserved positions of the oxyanion hole and catalytic nucleophile; different constituent families contain different additional structures

5. Family c.23.16.1: Class I glutamine amidotransferases (GAT) [52318] (12 proteins)
   contains a catalytic Cys-His-Glu triad

Proteins:

1. Anthranilate synthase GAT subunit, TrpG [52323] (3 species)

   1. Species Salmonella typhimurium [TaxId:90371] [63969] (1 PDB entry)

   2. Species Serratia marcescens [TaxId:615] [63970] (2 PDB entries)

   3. Species Sulfolobus solfataricus [TaxId:2287] [52324] (1 PDB entry)

2. Carbamoyl phosphate synthetase, small subunit C-terminal domain [52321] (1 species)

   • Species Escherichia coli [TaxId:562] [52322] (10 PDB entries)
     Uniprot P00907

3. CTP synthase PyrG, C-terminal domain [110481] (2 species)

   1. Species Escherichia coli [TaxId:562] [110482] (1 PDB entry)
      Uniprot P08398

   2. Species Thermus thermophilus [TaxId:274] [110483] (3 PDB entries)
      Uniprot Q5SIA8

4. FGAM synthase PurL, amidotransferase domain [110484] (3 species)

   1. Species Salmonella enterica [TaxId:90371] [227357] (2 PDB entries)

   2. Species Salmonella typhimurium [TaxId:90371] [110485] (1 PDB entry)
      Uniprot P74881

   3. Species Salmonella typhimurium [TaxId:99287] [229696] (1 PDB entry)

5. gamma-glutamyl hydrolase [75154] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75155] (1 PDB entry)

6. GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF [69447] (4 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69449] (4 PDB entries)

   2. Species Thermotoga maritima [TaxId:2336] [69448] (9 PDB entries)

   3. Species Thermotoga maritima [TaxId:243274] [404399] (1 PDB entry)

   4. Species Thermus thermophilus [TaxId:274] [82350] (1 PDB entry)

7. GMP synthase subunit A, GuaAA [142065] (2 species)

   1. Species Pyrococcus horikoshii [TaxId:53953] [142067] (1 PDB entry)
      Uniprot O59071 1-188

   2. Species Thermoplasma acidophilum [TaxId:2303] [142066] (1 PDB entry)
      Uniprot Q9HJM3 1-196

8. GMP synthetase [52319] (2 species)

   1. Species Escherichia coli [TaxId:562] [52320] (1 PDB entry)

   2. Species Thermus thermophilus HB8 [TaxId:300852] [255715] (2 PDB entries)

9. Hypothetical protein TM1158 [89599] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [89600] (1 PDB entry)

10. Hypothetical protein YaaE [102250] (4 species)
    glutamine amidotransferase of SNO/PDX2 family implicated in pyridoxine biosynthesis

    1. Species Bacillus stearothermophilus [TaxId:1422] [102252] (1 PDB entry)

    2. Species Bacillus subtilis [TaxId:1423] [102251] (2 PDB entries)

    3. Species Thermotoga maritima [TaxId:2336] [187876] (1 PDB entry)

    4. Species Thermus thermophilus HB8 [TaxId:300852] [194720] (1 PDB entry)

11. Pyridoxine biosynthesis protein 2, Pdx2 [142068] (1 species)

    • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [142069] (1 PDB entry)
      Uniprot Q5ND68 2-219

12. automated matches [190743] (4 species)
    not a true protein

    1. Species Bacillus subtilis [TaxId:1423] [187927] (1 PDB entry)

    2. Species Geobacillus kaustophilus [TaxId:235909] [269093] (1 PDB entry)

    3. Species Methanocaldococcus jannaschii [TaxId:243232] [255467] (1 PDB entry)

    4. Species Pyrococcus horikoshii OT3 [TaxId:70601] [225180] (1 PDB entry)

More info for Family c.23.16.1: Class I glutamine amidotransferases (GAT)

Timeline for Family c.23.16.1: Class I glutamine amidotransferases (GAT):

• Family c.23.16.1: Class I glutamine amidotransferases (GAT) first appeared (with stable ids) in SCOP 1.55
  
• Family c.23.16.1: Class I glutamine amidotransferases (GAT) appears in SCOPe 2.06
  
• Family c.23.16.1: Class I glutamine amidotransferases (GAT) appears in the current release, SCOPe 2.08