SCOPe 2.08: Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain

Lineage for Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
   3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

4. Superfamily c.23.12: Formate/glycerate dehydrogenase catalytic domain-like [52283] (3 families)

5. Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain [52284] (7 proteins)
   this domain is interrupted by the Rossmann-fold domain

Proteins:

1. D-2-hydroxyisocaproate dehydrogenase [52289] (1 species)

   • Species Lactobacillus casei [TaxId:1582] [52290] (1 PDB entry)

2. D-glycerate dehydrogenase [52291] (1 species)

   • Species Hyphomicrobium methylovorum [TaxId:84] [52292] (1 PDB entry)

3. D-lactate dehydrogenase [52295] (1 species)

   • Species Lactobacillus helveticus [TaxId:1587] [52296] (3 PDB entries)

4. Formate dehydrogenase [52285] (1 species)
   contains an additional beta-hairpin after the common fold

   • Species Pseudomonas sp., strain 101 [TaxId:306] [52286] (2 PDB entries)

5. Phosphoglycerate dehydrogenase [52293] (2 species)
   has additional C-terminal domain of the ferredoxin fold

   1. Species Escherichia coli [TaxId:562] [52294] (7 PDB entries)

   2. Species Mycobacterium tuberculosis [TaxId:1773] [142063] (2 PDB entries)
      Uniprot P0A544 2-97,282-315
      there is an intervening domain between this domain and regulatory (C-terminal) domain

6. Putative formate dehydrogenase [52287] (1 species)

   • Species Pyrobaculum aerophilum [TaxId:13773] [52288] (1 PDB entry)

7. Transcription corepressor CtbP [82347] (2 species)
   C-terminal binding protein 1; a dehydrogenase

   1. Species Human (Homo sapiens), Ctbp1 [TaxId:9606] [82348] (4 PDB entries)

   2. Species Norway rat (Rattus norvegicus), Ctbp3 [TaxId:10116] [89597] (2 PDB entries)

More info for Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain

Timeline for Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain:

• Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.23.12.1: Formate/glycerate dehydrogenases, substrate-binding domain appears in SCOPe 2.07