SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily c.10.2: L domain-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2098542Fold c.10: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3 superfamilies)
    2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
  4. 2098611Superfamily c.10.2: L domain-like [52058] (9 families) (S)
    less regular structure consisting of variable repeats


  1. 2098612c.10.2.1: Internalin LRR domain [52059] (4 protein domains)
    capped at the N-end with a truncated EF-hand subdomain
  2. 2098653c.10.2.2: Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [52062] (1 protein)
  3. 2098659c.10.2.3: mRNA export factor tap [52065] (2 protein domains)
  4. 2098682c.10.2.4: U2A'-like [52068] (1 protein)
    duplication: consists of 5-6 partly irregular repeats
  5. 2098687c.10.2.5: L domain [52071] (6 protein domains)
  6. 2098749c.10.2.6: Leucine rich effector protein YopM [69433] (1 protein)
  7. 2098754c.10.2.7: Ngr ectodomain-like [75142] (7 protein domains)
  8. 2098801c.10.2.8: Polygalacturonase inhibiting protein PGIP [89569] (1 protein)
  9. 2098805c.10.2.0: automated matches [191489] (1 protein)
    not a true family

More info for Superfamily c.10.2: L domain-like

Timeline for Superfamily c.10.2: L domain-like: