SCOPe 2.05: Family c.8.2.1: LeuD-like

Lineage for Family c.8.2.1: LeuD-like

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.8: The "swivelling" beta/beta/alpha domain [52008] (10 superfamilies)
   3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
   this domain is thought to be mobile in most multi-domain proteins known to contain it

4. Superfamily c.8.2: LeuD/IlvD-like [52016] (4 families)
   contains mixed beta-sheet barrel, closed n=7, S=10

5. Family c.8.2.1: LeuD-like [52017] (4 proteins)
   Pfam PF00694; permutation of the domain order in the proteins containing this family domain

Proteins:

1. Aconitase A, C-terminal domain [52018] (2 species)
   other three domains have alpha/beta folds

   1. Species Cow (Bos taurus) [TaxId:9913] [52020] (9 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [52019] (6 PDB entries)

2. Aconitase B, second N-terminal domain [75135] (1 species)

   • Species Escherichia coli [TaxId:562] [75136] (1 PDB entry)

3. Isopropylmalate isomerase LeuD [117454] (1 species)
   3-isopropylmalate dehydratase small subunit

   • Species Pyrococcus horikoshii [TaxId:53953] [117455] (1 PDB entry)
     Uniprot O59393

4. ron-responsive element binding protein 1, C-terminal domain [141974] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141975] (2 PDB entries)
     Uniprot P21399 631-889

More info for Family c.8.2.1: LeuD-like

Timeline for Family c.8.2.1: LeuD-like:

• Family c.8.2.1: LeuD-like first appeared (with stable ids) in SCOP 1.55, called Family c.8.2.1: Aconitase, C-terminal domain
  
• Family c.8.2.1: LeuD-like appears in SCOPe 2.04
  
• Family c.8.2.1: LeuD-like appears in SCOPe 2.06
  
• Family c.8.2.1: LeuD-like appears in the current release, SCOPe 2.08