SCOPe 2.03: Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

Lineage for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (8 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (15 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

Proteins:

1. Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains [51953] (2 species)

   1. Species Escherichia coli [TaxId:562] [63949] (1 PDB entry)

   2. Species Salmonella typhimurium [TaxId:90371] [51954] (1 PDB entry)

2. Apoptosis-inducing factor (AIF) [75126] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [75127] (1 PDB entry)

   2. Species Mouse (Mus musculus) [TaxId:10090] [75128] (1 PDB entry)

3. Dihydrolipoamide dehydrogenase [51959] (8 species)

   1. Species Azotobacter vinelandii [TaxId:354] [51962] (1 PDB entry)

   2. Species Bacillus stearothermophilus [TaxId:1422] [51963] (1 PDB entry)

   3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [63950] (2 PDB entries)

   4. Species Mycobacterium tuberculosis [TaxId:1773] [117441] (1 PDB entry)
      Uniprot O53355

   5. Species Neisseria meningitidis [TaxId:487] [51964] (2 PDB entries)

   6. Species Pea (Pisum sativum) [TaxId:3888] [51965] (1 PDB entry)

   7. Species Pseudomonas fluorescens [TaxId:294] [51961] (1 PDB entry)

   8. Species Pseudomonas putida [TaxId:303] [51960] (1 PDB entry)

4. Flavin-dependent monoxygenase SPBP16F5.08c [117444] (1 species)

   • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [117445] (3 PDB entries)
     Uniprot Q9HFE4

5. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [51966] (1 species)
   has a smaller C-terminal alpha+beta domain instead the "interface" domain

   • Species Chromatium vinosum [TaxId:1049] [51967] (1 PDB entry)

6. Glutathione reductase [51944] (3 species)

   1. Species Escherichia coli [TaxId:562] [51946] (4 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [51945] (22 PDB entries)

   3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [89548] (1 PDB entry)

7. Mammalian thioredoxin reductase [63947] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [63948] (1 PDB entry)

8. NADH oxidase /nitrite reductase [117442] (1 species)

   • Species Pyrococcus furiosus [TaxId:2261] [117443] (1 PDB entry)
     Uniprot Q8U1K9

9. NADH peroxidase [51955] (1 species)

   • Species Enterococcus faecalis [TaxId:1351] [51956] (8 PDB entries)

10. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82313] (1 species)

    • Species Xanthobacter sp., py2 [TaxId:35809] [82314] (5 PDB entries)

11. NADH-dependent ferredoxin reductase, BphA4 [51957] (1 species)

    • Species Pseudomonas sp., KKS102 [TaxId:306] [51958] (9 PDB entries)

12. Phenylacetone monooxygenase [110440] (1 species)

    • Species Thermobifida fusca [TaxId:2021] [110441] (5 PDB entries)
      Uniprot Q5YS95 # 55% sequence identity; Nocardia farcinica TaxID:37329

13. Putidaredoxin reductase [102185] (1 species)

    • Species Pseudomonas putida [TaxId:303] [102186] (2 PDB entries)

14. Thioredoxin reductase [51950] (2 species)
    lacks the "interface" C-terminal alpha+beta domain

    1. Species Escherichia coli [TaxId:562] [51951] (5 PDB entries)

    2. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [51952] (1 PDB entry)

15. Trypanothione reductase [51947] (2 species)

    1. Species Crithidia fasciculata [TaxId:5656] [51948] (6 PDB entries)

    2. Species Trypanosoma cruzi [TaxId:5693] [51949] (4 PDB entries)

More info for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

Timeline for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains:

• Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains first appeared (with stable ids) in SCOP 1.55
  
• Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains appears in SCOPe 2.02
  
• Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains appears in SCOPe 2.04
  
• Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains appears in the current release, SCOPe 2.08