SCOP 1.71: Species: Human (Homo sapiens)

Lineage for Species: Human (Homo sapiens)

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (11 proteins)
extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
includes C-terminal additional subdomains
Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)

PDB entries in Species: Human (Homo sapiens):

Domain(s) for 1do8:
1. Domain d1do8a1: 1do8 A:280-573 [30289]
  Other proteins in same PDB: d1do8a2, d1do8b2, d1do8c2, d1do8d2
2. Domain d1do8b1: 1do8 B:280-573 [30290]
  Other proteins in same PDB: d1do8a2, d1do8b2, d1do8c2, d1do8d2
3. Domain d1do8c1: 1do8 C:280-573 [30291]
  Other proteins in same PDB: d1do8a2, d1do8b2, d1do8c2, d1do8d2
4. Domain d1do8d1: 1do8 D:280-573 [30292]
  Other proteins in same PDB: d1do8a2, d1do8b2, d1do8c2, d1do8d2
  complexed with mn, nad, oxl; mutant
Domain(s) for 1efk:
1. Domain d1efka1: 1efk A:280-573 [30299]
  Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
2. Domain d1efkb1: 1efk B:280-573 [30300]
  Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
3. Domain d1efkc1: 1efk C:280-573 [30301]
  Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
4. Domain d1efkd1: 1efk D:280-573 [30302]
  Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
  complexed with mak, mo1, nad
Domain(s) for 1efl:
1. Domain d1efla1: 1efl A:280-573 [30295]
  Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
2. Domain d1eflb1: 1efl B:280-573 [30296]
  Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
3. Domain d1eflc1: 1efl C:280-573 [30297]
  Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
4. Domain d1efld1: 1efl D:280-573 [30298]
  Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
  complexed with mg, nad, ttn
Domain(s) for 1gz3:
1. Domain d1gz3a1: 1gz3 A:280-573 [83393]
  Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
2. Domain d1gz3b1: 1gz3 B:280-573 [83395]
  Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
3. Domain d1gz3c1: 1gz3 C:280-573 [83397]
  Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
4. Domain d1gz3d1: 1gz3 D:280-573 [83399]
  Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
  complexed with atp, fum, mn, oxl; mutant
Domain(s) for 1gz4:
1. Domain d1gz4a1: 1gz4 A:280-573 [70794]
  Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
2. Domain d1gz4b1: 1gz4 B:280-573 [70796]
  Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
3. Domain d1gz4c1: 1gz4 C:280-573 [70798]
  Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
4. Domain d1gz4d1: 1gz4 D:280-573 [70800]
  Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
  complexed with atp, fum, mn, mse, ttn
Domain(s) for 1pj2:
1. Domain d1pj2a1: 1pj2 A:280-573 [94718]
  Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
2. Domain d1pj2b1: 1pj2 B:1280-1573 [94720]
  Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
3. Domain d1pj2c1: 1pj2 C:2280-2573 [94722]
  Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
4. Domain d1pj2d1: 1pj2 D:3280-3573 [94724]
  Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
  complexed with fum, mlt, mn, nai
Domain(s) for 1pj3:
1. Domain d1pj3a1: 1pj3 A:280-573 [94726]
  Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
2. Domain d1pj3b1: 1pj3 B:1280-1573 [94728]
  Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
3. Domain d1pj3c1: 1pj3 C:2280-2573 [94730]
  Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
4. Domain d1pj3d1: 1pj3 D:3280-3573 [94732]
  Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
  complexed with fum, mn, nad, pyr
Domain(s) for 1pj4:
1. Domain d1pj4a1: 1pj4 A:280-573 [94734]
  Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
2. Domain d1pj4b1: 1pj4 B:1280-1573 [94736]
  Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
3. Domain d1pj4c1: 1pj4 C:2280-2573 [94738]
  Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
4. Domain d1pj4d1: 1pj4 D:3280-3573 [94740]
  Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
  complexed with atp, fum, mlt, mn
Domain(s) for 1pjl:
1. Domain d1pjla1: 1pjl A:280-573 [88123]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
2. Domain d1pjlb1: 1pjl B:1280-1573 [88125]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
3. Domain d1pjlc1: 1pjl C:2280-2573 [88127]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
4. Domain d1pjld1: 1pjl D:3280-3573 [88129]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
5. Domain d1pjle1: 1pjl E:4280-4573 [88131]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
6. Domain d1pjlf1: 1pjl F:5280-5573 [88133]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
7. Domain d1pjlg1: 1pjl G:6280-6573 [88135]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
8. Domain d1pjlh1: 1pjl H:7280-7573 [88137]
  Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
  complexed with lu, mse, nad
Domain(s) for 1qr6:
1. Domain d1qr6a1: 1qr6 A:280-573 [30293]
  Other proteins in same PDB: d1qr6a2, d1qr6b2
2. Domain d1qr6b1: 1qr6 B:1280-1573 [30294]
  Other proteins in same PDB: d1qr6a2, d1qr6b2
  complexed with nad; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme:

Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme first appeared (with stable ids) in SCOP 1.55, called Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependenent malic enzyme
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme appears in SCOP 1.69
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme appears in SCOP 1.73
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.7 Mitochondrial NAD(P)-dependent malic enzyme appears in the current release, SCOPe 2.08