Lineage for Protein: Mitochondrial NAD(P)-dependent malic enzyme

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2093723Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 protein domains)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  6. 2093883Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains

Species:

  1. 2093884Domestic pigeon (Columba livia) [TaxId:8932] [75116] (1 PDB entry)
  2. 2093901Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
    1. Domains for 1do8:
      1. 2093922Domain d1do8a1: 1do8 A:280-573 [30289]
        Other proteins in same PDB: d1do8a2, d1do8b4, d1do8c4, d1do8d4
        complexed with mn, nad, oxl
      2. 2093923Domain d1do8b3: 1do8 B:1280-1573 [197453]
        Other proteins in same PDB: d1do8a2, d1do8b4, d1do8c4, d1do8d4
        complexed with mn, nad, oxl
      3. 2093924Domain d1do8c3: 1do8 C:2280-2573 [197455]
        Other proteins in same PDB: d1do8a2, d1do8b4, d1do8c4, d1do8d4
        complexed with mn, nad, oxl
      4. 2093925Domain d1do8d3: 1do8 D:3280-3573 [197457]
        Other proteins in same PDB: d1do8a2, d1do8b4, d1do8c4, d1do8d4
        complexed with mn, nad, oxl
    2. Domains for 1efk:
      1. 2093932Domain d1efka1: 1efk A:280-573 [30299]
        Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
        complexed with mak, mg, nad
      2. 2093933Domain d1efkb1: 1efk B:280-573 [30300]
        Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
        complexed with mak, mg, nad
      3. 2093934Domain d1efkc1: 1efk C:280-573 [30301]
        Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
        complexed with mak, mg, nad
      4. 2093935Domain d1efkd1: 1efk D:280-573 [30302]
        Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
        complexed with mak, mg, nad
    3. Domains for 1efl:
      1. 2093928Domain d1efla1: 1efl A:280-573 [30295]
        Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
        complexed with mg, nad, ttn
      2. 2093929Domain d1eflb1: 1efl B:280-573 [30296]
        Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
        complexed with mg, nad, ttn
      3. 2093930Domain d1eflc1: 1efl C:280-573 [30297]
        Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
        complexed with mg, nad, ttn
      4. 2093931Domain d1efld1: 1efl D:280-573 [30298]
        Other proteins in same PDB: d1efla2, d1eflb2, d1eflc2, d1efld2
        complexed with mg, nad, ttn
    4. Domains for 1gz3:
      1. 2093906Domain d1gz3a1: 1gz3 A:280-573 [83393]
        Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
        complexed with atp, fum, mn, oxl
      2. 2093907Domain d1gz3b1: 1gz3 B:280-573 [83395]
        Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
        complexed with atp, fum, mn, oxl
      3. 2093908Domain d1gz3c1: 1gz3 C:280-573 [83397]
        Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
        complexed with atp, fum, mn, oxl
      4. 2093909Domain d1gz3d1: 1gz3 D:280-573 [83399]
        Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
        complexed with atp, fum, mn, oxl
    5. Domains for 1gz4:
      1. 2093910Domain d1gz4a1: 1gz4 A:280-573 [70794]
        Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
        complexed with atp, fum, mn, ttn
      2. 2093911Domain d1gz4b1: 1gz4 B:280-573 [70796]
        Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
        complexed with atp, fum, mn, ttn
      3. 2093912Domain d1gz4c1: 1gz4 C:280-573 [70798]
        Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
        complexed with atp, fum, mn, ttn
      4. 2093913Domain d1gz4d1: 1gz4 D:280-573 [70800]
        Other proteins in same PDB: d1gz4a2, d1gz4b2, d1gz4c2, d1gz4d2
        complexed with atp, fum, mn, ttn
    6. Domains for 1pj2:
      1. 2093914Domain d1pj2a1: 1pj2 A:280-573 [94718]
        Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
        complexed with fum, mlt, mn, nai
      2. 2093915Domain d1pj2b1: 1pj2 B:1280-1573 [94720]
        Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
        complexed with fum, mlt, mn, nai
      3. 2093916Domain d1pj2c1: 1pj2 C:2280-2573 [94722]
        Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
        complexed with fum, mlt, mn, nai
      4. 2093917Domain d1pj2d1: 1pj2 D:3280-3573 [94724]
        Other proteins in same PDB: d1pj2a2, d1pj2b2, d1pj2c2, d1pj2d2
        complexed with fum, mlt, mn, nai
    7. Domains for 1pj3:
      1. 2093902Domain d1pj3a1: 1pj3 A:280-573 [94726]
        Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
        complexed with fum, mn, nad, pyr
      2. 2093903Domain d1pj3b1: 1pj3 B:1280-1573 [94728]
        Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
        complexed with fum, mn, nad, pyr
      3. 2093904Domain d1pj3c1: 1pj3 C:2280-2573 [94730]
        Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
        complexed with fum, mn, nad, pyr
      4. 2093905Domain d1pj3d1: 1pj3 D:3280-3573 [94732]
        Other proteins in same PDB: d1pj3a2, d1pj3b2, d1pj3c2, d1pj3d2
        complexed with fum, mn, nad, pyr
    8. Domains for 1pj4:
      1. 2093918Domain d1pj4a1: 1pj4 A:280-573 [94734]
        Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
        complexed with atp, fum, mlt, mn
      2. 2093919Domain d1pj4b1: 1pj4 B:1280-1573 [94736]
        Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
        complexed with atp, fum, mlt, mn
      3. 2093920Domain d1pj4c1: 1pj4 C:2280-2573 [94738]
        Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
        complexed with atp, fum, mlt, mn
      4. 2093921Domain d1pj4d1: 1pj4 D:3280-3573 [94740]
        Other proteins in same PDB: d1pj4a2, d1pj4b2, d1pj4c2, d1pj4d2
        complexed with atp, fum, mlt, mn
    9. Domains for 1pjl:
      1. 2093936Domain d1pjla1: 1pjl A:280-573 [88123]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      2. 2093937Domain d1pjlb1: 1pjl B:1280-1573 [88125]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      3. 2093938Domain d1pjlc1: 1pjl C:2280-2573 [88127]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      4. 2093939Domain d1pjld1: 1pjl D:3280-3573 [88129]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      5. 2093940Domain d1pjle1: 1pjl E:4280-4573 [88131]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      6. 2093941Domain d1pjlf1: 1pjl F:5280-5573 [88133]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      7. 2093942Domain d1pjlg1: 1pjl G:6280-6573 [88135]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
      8. 2093943Domain d1pjlh1: 1pjl H:7280-7573 [88137]
        Other proteins in same PDB: d1pjla2, d1pjlb2, d1pjlc2, d1pjld2, d1pjle2, d1pjlf2, d1pjlg2, d1pjlh2
        complexed with lu, nad
    10. Domains for 1qr6:
      1. 2093926Domain d1qr6a1: 1qr6 A:280-573 [30293]
        Other proteins in same PDB: d1qr6a2, d1qr6b2
        complexed with nad
      2. 2093927Domain d1qr6b1: 1qr6 B:1280-1573 [30294]
        Other proteins in same PDB: d1qr6a2, d1qr6b2
        complexed with nad
  3. 2093944Pig roundworm (Ascaris suum) [TaxId:6253] [75117] (2 PDB entries)
    1. Domains for 1llq:
      1. 2093947Domain d1llqa1: 1llq A:296-600 [74008]
        Other proteins in same PDB: d1llqa2, d1llqb2
        complexed with nad
      2. 2093948Domain d1llqb1: 1llq B:296-593 [74010]
        Other proteins in same PDB: d1llqa2, d1llqb2
        complexed with nad
    2. Domains for 1o0s:
      1. 2093945Domain d1o0sa1: 1o0s A:296-603 [86540]
        Other proteins in same PDB: d1o0sa2, d1o0sb2
        complexed with nai, ttn
      2. 2093946Domain d1o0sb1: 1o0s B:296-593 [86542]
        Other proteins in same PDB: d1o0sa2, d1o0sb2
        complexed with nai, ttn

More info for Protein Mitochondrial NAD(P)-dependent malic enzyme from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

Timeline for Protein Mitochondrial NAD(P)-dependent malic enzyme from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain: