SCOP 1.67: Protein: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase

Lineage for Protein: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase

Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (10 proteins)
extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51897] (2 PDB entries)
1. Domain for 1edz:
  - Domain d1edza1: 1edz A:149-319 [30287]
    Other proteins in same PDB: d1edza2
2. Domain for 1ee9:
  - Domain d1ee9a1: 1ee9 A:149-319 [30288]
    Other proteins in same PDB: d1ee9a2
    complexed with nad
Escherichia coli [TaxId:562] [51896] (1 PDB entry)
- Domain for 1b0a:
  - Domain d1b0aa1: 1b0a A:123-288 [30286]
    Other proteins in same PDB: d1b0aa2
Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)
1. Domains for 1a4i:
  1. Domain d1a4ia1: 1a4i A:127-296 [30278]
    Other proteins in same PDB: d1a4ia2, d1a4ib2
  2. Domain d1a4ib1: 1a4i B:127-296 [30279]
    Other proteins in same PDB: d1a4ia2, d1a4ib2
    complexed with ndp
2. Domains for 1dia:
  1. Domain d1diaa1: 1dia A:127-296 [30280]
    Other proteins in same PDB: d1diaa2, d1diab2
  2. Domain d1diab1: 1dia B:1127-1296 [30281]
    Other proteins in same PDB: d1diaa2, d1diab2
    complexed with l24, nap
3. Domains for 1dib:
  1. Domain d1diba1: 1dib A:127-296 [30284]
    Other proteins in same PDB: d1diba2, d1dibb2
  2. Domain d1dibb1: 1dib B:1127-1296 [30285]
    Other proteins in same PDB: d1diba2, d1dibb2
    complexed with l34, nap
4. Domains for 1dig:
  1. Domain d1diga1: 1dig A:127-296 [30282]
    Other proteins in same PDB: d1diga2, d1digb2
  2. Domain d1digb1: 1dig B:1127-1296 [30283]
    Other proteins in same PDB: d1diga2, d1digb2
    complexed with act, l37, nap

More info for Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

Timeline for Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain:

Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain first appeared (with stable ids) in SCOP 1.55, called Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Amino-acid dehydrogenase-like, C-terminal domain
Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain appears in SCOP 1.65
Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain appears in SCOP 1.69
Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain appears in the current release, SCOPe 2.08