![]() | Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
![]() | Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
![]() | Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) ![]() |
![]() | Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins) extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site |
![]() | Glutamate dehydrogenase [51884] (8 species) |
![]() | Species Clostridium symbiosum [TaxId:1512] [51885] (4 PDB entries) |
![]() | Species Cow (Bos taurus) [TaxId:9913] [51889] (6 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [75115] (2 PDB entries) |
![]() | Species Pyrobaculum islandicum [TaxId:2277] [117436] (1 PDB entry) Uniprot Q9Y8I4 |
![]() | Species Pyrococcus furiosus [TaxId:2261] [51886] (1 PDB entry) |
![]() | Species Thermococcus litoralis [TaxId:2265] [51887] (1 PDB entry) |
![]() | Species Thermococcus profundus [TaxId:49899] [63943] (1 PDB entry) |
![]() | Species Thermotoga maritima [TaxId:2336] [51888] (3 PDB entries) |
![]() | Glutamyl tRNA-reductase middle domain [69413] (1 species) other domains of this protein are distinct from those usually associated with the family domain |
![]() | Species Methanopyrus kandleri [TaxId:2320] [69414] (1 PDB entry) |
![]() | Leucine dehydrogenase [51890] (1 species) |
![]() | Species Bacillus sphaericus [TaxId:1421] [51891] (1 PDB entry) |
![]() | Malate oxidoreductase (malic enzyme) [110434] (1 species) |
![]() | Species Thermotoga maritima [TaxId:2336] [110435] (1 PDB entry) Uniprot Q9WZ12 |
![]() | Methylene-tetrahydromethanopterin dehydrogenase [82303] (1 species) |
![]() | Species Methylobacterium extorquens [TaxId:408] [82304] (2 PDB entries) |
![]() | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species) the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated |
![]() | Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51897] (2 PDB entries) |
![]() | Species Escherichia coli [TaxId:562] [51896] (1 PDB entry) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries) |
![]() | Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species) includes C-terminal additional subdomains |
![]() | Species Domestic pigeon (Columba livia) [TaxId:8932] [75116] (1 PDB entry) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries) |
![]() | Species Pig roundworm (Ascaris suum) [TaxId:6253] [75117] (2 PDB entries) |
![]() | Phenylalanine dehydrogenase [51892] (1 species) |
![]() | Species Rhodococcus sp., M4 [TaxId:1831] [51893] (4 PDB entries) |
![]() | Putative shikimate dehydrogenase YdiB [82305] (1 species) |
![]() | Species Escherichia coli [TaxId:562] [82306] (3 PDB entries) |
![]() | Shikimate 5-dehydrogenase AroE [89538] (6 species) |
![]() | Species Aquifex aeolicus [TaxId:63363] [225281] (3 PDB entries) |
![]() | Species Escherichia coli [TaxId:562] [89539] (1 PDB entry) |
![]() | Species Geobacillus kaustophilus [TaxId:1462] [225426] (1 PDB entry) |
![]() | Species Haemophilus influenzae [TaxId:727] [102173] (2 PDB entries) |
![]() | Species Methanococcus jannaschii [TaxId:2190] [89540] (1 PDB entry) MJ1084 |
![]() | Species Staphylococcus epidermidis [TaxId:176279] [225658] (2 PDB entries) |
![]() | Shikimate 5-dehydrogenase-like protein HI0607 [89536] (1 species) |
![]() | Species Haemophilus influenzae [TaxId:727] [89537] (1 PDB entry) |
![]() | automated matches [227005] (3 species) not a true protein |
![]() | Species Cow (Bos taurus) [TaxId:9913] [225674] (3 PDB entries) |
![]() | Species Salmonella enterica [TaxId:90371] [226190] (1 PDB entry) |
Species Thermotoga maritima [TaxId:2336] [255206] (1 PDB entry) |
Timeline for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain: