Lineage for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 476939Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 476940Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 478576Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (11 proteins)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Proteins:

  1. 478577Glutamate dehydrogenase [51884] (7 species)
    1. 478578Species Archaeon Pyrococcus furiosus [TaxId:2261] [51886] (1 PDB entry)
    2. 478582Species Archaeon Thermococcus litoralis [TaxId:2265] [51887] (1 PDB entry)
    3. 478589Species Archaeon Thermococcus profundus [TaxId:49899] [63943] (1 PDB entry)
    4. 478596Species Clostridium symbiosum [TaxId:1512] [51885] (4 PDB entries)
    5. 478603Species Cow (Bos taurus) [TaxId:9913] [51889] (5 PDB entries)
    6. 478646Species Human (Homo sapiens) [TaxId:9606] [75115] (2 PDB entries)
    7. 478659Species Thermotoga maritima [TaxId:243274] [51888] (3 PDB entries)
  2. 478678Glutamyl tRNA-reductase middle domain [69413] (1 species)
    other domains of this protein are distinct from those usually associated with the family domain
  3. 478681Leucine dehydrogenase [51890] (1 species)
  4. 478685Malate oxidoreductase (malic enzyme) [110434] (1 species)
  5. 478691Methylene-tetrahydromethanopterin dehydrogenase [82303] (1 species)
  6. 478699Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
    the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
    1. 478700Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51897] (2 PDB entries)
    2. 478703Species Escherichia coli [TaxId:562] [51896] (1 PDB entry)
    3. 478705Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)
  7. 478714Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains
    1. 478715Species Domestic pigeon (Columba livia) [TaxId:8932] [75116] (1 PDB entry)
    2. 478732Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
    3. 478775Species Pig roundworm (Ascaris suum) [TaxId:6253] [75117] (2 PDB entries)
  8. 478780Phenylalanine dehydrogenase [51892] (1 species)
  9. 478790Putative shikimate dehydrogenase YdiB [82305] (1 species)
  10. 478798Shikimate 5-dehydrogenase AroE [89538] (3 species)
    1. 478799Species Archaeon Methanococcus jannaschii [TaxId:2190] [89540] (1 PDB entry)
      MJ1084
    2. 478802Species Escherichia coli [TaxId:562] [89539] (1 PDB entry)
    3. 478807Species Haemophilus influenzae [TaxId:727] [102173] (2 PDB entries)
  11. 478811Shikimate 5-dehydrogenase-like protein HI0607 [89536] (1 species)

More info for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

Timeline for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain: