Lineage for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2093723Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 protein domains)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Protein Domains:

  1. 2093724Glutamate dehydrogenase [51884] (8 species)
    1. 2093725Species Clostridium symbiosum [TaxId:1512] [51885] (4 PDB entries)
    2. 2093732Species Cow (Bos taurus) [TaxId:9913] [51889] (8 PDB entries)
    3. 2093790Species Human (Homo sapiens) [TaxId:9606] [75115] (2 PDB entries)
    4. 2093803Species Pyrobaculum islandicum [TaxId:2277] [117436] (1 PDB entry)
      Uniprot Q9Y8I4
    5. 2093810Species Pyrococcus furiosus [TaxId:2261] [51886] (1 PDB entry)
    6. 2093814Species Thermococcus litoralis [TaxId:2265] [51887] (1 PDB entry)
    7. 2093821Species Thermococcus profundus [TaxId:49899] [63943] (1 PDB entry)
    8. 2093828Species Thermotoga maritima [TaxId:2336] [51888] (3 PDB entries)
  2. 2093847Glutamyl tRNA-reductase middle domain [69413] (1 species)
    other domains of this protein are distinct from those usually associated with the family domain
  3. 2093850Leucine dehydrogenase [51890] (1 species)
  4. 2093854Malate oxidoreductase (malic enzyme) [110434] (1 species)
  5. 2093860Methylene-tetrahydromethanopterin dehydrogenase [82303] (1 species)
  6. 2093868Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
    the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
    1. 2093869Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51897] (2 PDB entries)
    2. 2093872Species Escherichia coli [TaxId:562] [51896] (1 PDB entry)
    3. 2093874Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)
  7. 2093883Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains
    1. 2093884Species Domestic pigeon (Columba livia) [TaxId:8932] [75116] (1 PDB entry)
    2. 2093901Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
    3. 2093944Species Pig roundworm (Ascaris suum) [TaxId:6253] [75117] (2 PDB entries)
  8. 2093949Phenylalanine dehydrogenase [51892] (1 species)
  9. 2093959Putative shikimate dehydrogenase YdiB [82305] (1 species)
  10. 2093967Shikimate 5-dehydrogenase AroE [89538] (6 species)
    1. 2093968Species Aquifex aeolicus [TaxId:63363] [225281] (3 PDB entries)
    2. 2093983Species Escherichia coli [TaxId:562] [89539] (1 PDB entry)
    3. 2093988Species Geobacillus kaustophilus [TaxId:1462] [225426] (1 PDB entry)
    4. 2093991Species Haemophilus influenzae [TaxId:727] [102173] (2 PDB entries)
    5. 2093995Species Methanococcus jannaschii [TaxId:2190] [89540] (1 PDB entry)
      MJ1084
    6. 2093998Species Staphylococcus epidermidis [TaxId:176279] [225658] (2 PDB entries)
  11. 2094001Shikimate 5-dehydrogenase-like protein HI0607 [89536] (1 species)
  12. 2094007automated matches [227005] (3 species)
    not a true protein
    1. 2094008Species Cow (Bos taurus) [TaxId:9913] [225674] (3 PDB entries)
    2. 2094027Species Salmonella enterica [TaxId:90371] [226190] (1 PDB entry)
    3. Species Thermotoga maritima [TaxId:2336] [255206] (1 PDB entry)

More info for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

Timeline for Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain: