Lineage for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 977684Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (18 proteins)
    the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
    C-terminal domains also show some similarity

Proteins:

  1. 9776855,10-methenyltetrahydromethanopterin hydrogenase, HMD [141932] (1 species)
  2. 9776886-phosphogluconate dehydrogenase [51871] (2 species)
    1. 977689Species Sheep (Ovis orientalis aries) [TaxId:9940] [51872] (5 PDB entries)
    2. 977695Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51873] (1 PDB entry)
  3. 977698Class I ketol-acid reductoisomerase (KARI) [89532] (1 species)
  4. 977704Class II ketol-acid reductoisomerase (KARI) [51869] (1 species)
    contains additional subdomain at the N-terminus, partly ordered
  5. 977714Coenzyme F420H2:NADP+ oxidoreductase (FNO) [69421] (1 species)
    lacks all but the first helix of the C-terminal all-alpha domain
  6. 977720Conserved hypothetical protein MTH1747 [75113] (1 species)
  7. 977724Fatty oxidation complex alpha subunit, middle domain [110432] (1 species)
  8. 977734GDP-mannose 6-dehydrogenase [89534] (1 species)
  9. 977748Glycerol-3- phosphate dehydrogenase [51881] (2 species)
    1. 977749Species Archaeoglobus fulgidus [TaxId:2234] [117433] (1 PDB entry)
      Uniprot O29390
    2. 977752Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51882] (7 PDB entries)
  10. 977761Hydroxyisobutyrate dehydrogenase [102171] (3 species)
    1. 977762Species Pseudomonas aeruginosa [TaxId:287] [159424] (1 PDB entry)
      Uniprot Q9I5I6 1-162
    2. 977764Species Salmonella typhimurium [TaxId:90371] [110431] (1 PDB entry)
      Uniprot Q8ZLV8
    3. 977766Species Thermus thermophilus [TaxId:274] [102172] (2 PDB entries)
      structural genomics
  11. 977775Hypothetical protein TM1727 [159426] (1 species)
    ProC structural homologue
  12. 977779Ketopantoate reductase PanE [69419] (1 species)
  13. 977786Mannitol 2-dehydrogenase [82301] (1 species)
  14. 977791N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [51879] (1 species)
  15. 977794Prephenate dehydrogenase TyrA [141929] (3 species)
    1. 977795Species Aquifex aeolicus [TaxId:63363] [141930] (1 PDB entry)
      Uniprot O67636 30-200
    2. 977800Species Haemophilus influenzae [TaxId:727] [159425] (1 PDB entry)
      Uniprot P43902 92-243
    3. 977803Species Synechocystis sp. PCC 6803 [TaxId:1148] [141931] (1 PDB entry)
      Uniprot P73906 1-165
  16. 977808Pyrroline-5-carboxylate reductase ProC [117434] (2 species)
    1. 977809Species Neisseria meningitidis, serogroup B [TaxId:487] [117435] (2 PDB entries)
      Uniprot Q9K1N1
    2. 977812Species Streptococcus pyogenes [TaxId:1314] [141928] (2 PDB entries)
      Uniprot Q9A1S9 1-152
  17. 977823Short chain L-3-hydroxyacyl CoA dehydrogenase [51874] (2 species)
    1. 977824Species Human (Homo sapiens) [TaxId:9606] [51875] (11 PDB entries)
    2. 977847Species Pig (Sus scrofa) [TaxId:9823] [51876] (1 PDB entry)
  18. 977851UDP-glucose dehydrogenase (UDPGDH) [51877] (1 species)

More info for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

Timeline for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain: