Lineage for Protein: Malate dehydrogenase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 819418Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 819419Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 821465Family c.2.1.5: LDH N-terminal domain-like [51848] (8 proteins)
  6. 821602Protein Malate dehydrogenase [51849] (12 species)

Species:

  1. 821603Aquaspirillum arcticum [TaxId:87645] [51856] (3 PDB entries)
    1. Domain for 1b8p:
    2. Domain for 1b8u:
    3. Domain for 1b8v:
  2. 821607Archaeon Archaeoglobus fulgidus [TaxId:2234] [110427] (2 PDB entries)
    Uniprot O08349
    1. Domain for 1ojs:
    2. Domain for 1oju:
  3. 821610Archaeon Haloarcula marismortui [TaxId:2238] [51855] (8 PDB entries)
    1. Domains for 1d3a:
      1. 821629Domain d1d3aa1: 1d3a A:22-162 [30143]
        Other proteins in same PDB: d1d3aa2, d1d3ab2
      2. 821630Domain d1d3ab1: 1d3a B:22-162 [30144]
        Other proteins in same PDB: d1d3aa2, d1d3ab2
        complexed with cl, na
    2. Domains for 1gt2:
      1. 821631Domain d1gt2a1: 1gt2 A:22-162 [76338]
        Other proteins in same PDB: d1gt2a2, d1gt2b2
      2. 821632Domain d1gt2b1: 1gt2 B:22-162 [76340]
        Other proteins in same PDB: d1gt2a2, d1gt2b2
        complexed with cl, na, nad; mutant
    3. Domains for 1hlp:
      1. 821633Domain d1hlpa1: 1hlp A:21-162 [30145]
        Other proteins in same PDB: d1hlpa2, d1hlpb2
      2. 821634Domain d1hlpb1: 1hlp B:21-162 [30146]
        Other proteins in same PDB: d1hlpa2, d1hlpb2
        complexed with nad
    4. Domains for 1o6z:
      1. 821611Domain d1o6za1: 1o6z A:22-162 [81107]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      2. 821612Domain d1o6zb1: 1o6z B:22-162 [81109]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      3. 821613Domain d1o6zc1: 1o6z C:22-162 [81111]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      4. 821614Domain d1o6zd1: 1o6z D:22-162 [81113]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
        complexed with cl, nad; mutant
    5. Domains for 2hlp:
      1. 821627Domain d2hlpa1: 2hlp A:22-162 [30141]
        Other proteins in same PDB: d2hlpa2, d2hlpb2
      2. 821628Domain d2hlpb1: 2hlp B:22-162 [30142]
        Other proteins in same PDB: d2hlpa2, d2hlpb2
    6. Domains for 2j5k:
      1. 821615Domain d2j5ka1: 2j5k A:22-163 [138037]
        Other proteins in same PDB: d2j5ka2, d2j5kb2, d2j5kc2, d2j5kd2
        automatically matched to d1hlpa1
        complexed with cl
      2. 821616Domain d2j5kb1: 2j5k B:22-163 [138039]
        Other proteins in same PDB: d2j5ka2, d2j5kb2, d2j5kc2, d2j5kd2
        automatically matched to d1hlpa1
        complexed with cl
      3. 821617Domain d2j5kc1: 2j5k C:22-163 [138041]
        Other proteins in same PDB: d2j5ka2, d2j5kb2, d2j5kc2, d2j5kd2
        automatically matched to d1hlpa1
        complexed with cl
      4. 821618Domain d2j5kd1: 2j5k D:22-163 [138043]
        Other proteins in same PDB: d2j5ka2, d2j5kb2, d2j5kc2, d2j5kd2
        automatically matched to d1hlpa1
        complexed with cl
    7. Domains for 2j5q:
      1. 821619Domain d2j5qa1: 2j5q A:22-163 [138051]
        Other proteins in same PDB: d2j5qa2, d2j5qb2, d2j5qc2, d2j5qd2
        automatically matched to d1hlpa1
        complexed with cl
      2. 821620Domain d2j5qb1: 2j5q B:22-163 [138053]
        Other proteins in same PDB: d2j5qa2, d2j5qb2, d2j5qc2, d2j5qd2
        automatically matched to d1hlpa1
        complexed with cl
      3. 821621Domain d2j5qc1: 2j5q C:22-163 [138055]
        Other proteins in same PDB: d2j5qa2, d2j5qb2, d2j5qc2, d2j5qd2
        automatically matched to d1hlpa1
        complexed with cl
      4. 821622Domain d2j5qd1: 2j5q D:22-163 [138057]
        Other proteins in same PDB: d2j5qa2, d2j5qb2, d2j5qc2, d2j5qd2
        automatically matched to d1hlpa1
        complexed with cl
    8. Domains for 2j5r:
      1. 821623Domain d2j5ra1: 2j5r A:22-163 [138059]
        Other proteins in same PDB: d2j5ra2, d2j5rb2, d2j5rc2, d2j5rd2
        automatically matched to d1hlpa1
        complexed with cl
      2. 821624Domain d2j5rb1: 2j5r B:22-163 [138061]
        Other proteins in same PDB: d2j5ra2, d2j5rb2, d2j5rc2, d2j5rd2
        automatically matched to d1hlpa1
        complexed with cl
      3. 821625Domain d2j5rc1: 2j5r C:22-163 [138063]
        Other proteins in same PDB: d2j5ra2, d2j5rb2, d2j5rc2, d2j5rd2
        automatically matched to d1hlpa1
        complexed with cl
      4. 821626Domain d2j5rd1: 2j5r D:22-163 [138065]
        Other proteins in same PDB: d2j5ra2, d2j5rb2, d2j5rc2, d2j5rd2
        automatically matched to d1hlpa1
        complexed with cl
  4. 821635Chlorobium tepidum [TaxId:1097] [69416] (1 PDB entry)
  5. 821638Chlorobium vibrioforme [TaxId:1098] [69417] (2 PDB entries)
    1. Domains for 1guz:
      1. 821639Domain d1guza1: 1guz A:1-142 [65586]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      2. 821640Domain d1guzb1: 1guz B:1-142 [65588]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      3. 821641Domain d1guzc1: 1guz C:1-142 [65590]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      4. 821642Domain d1guzd1: 1guz D:1-142 [65592]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
        complexed with nad
    2. Domains for 1gv1:
      1. 821643Domain d1gv1a1: 1gv1 A:1-142 [65598]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      2. 821644Domain d1gv1b1: 1gv1 B:1-142 [65600]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      3. 821645Domain d1gv1c1: 1gv1 C:1-142 [65602]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      4. 821646Domain d1gv1d1: 1gv1 D:1-142 [65604]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
  6. 821647Chloroflexus aurantiacus [TaxId:1108] [69415] (7 PDB entries)
    Uniprot P80040
    1. Domains for 1guy:
      1. 821654Domain d1guya1: 1guy A:1-143 [65582]
        Other proteins in same PDB: d1guya2, d1guyc2
      2. 821655Domain d1guyc1: 1guy C:1-143 [65584]
        Other proteins in same PDB: d1guya2, d1guyc2
        complexed with cd, nad
    2. Domains for 1ur5:
      1. 821650Domain d1ur5a1: 1ur5 A:2-143 [99807]
        Other proteins in same PDB: d1ur5a2, d1ur5c2
      2. 821651Domain d1ur5c1: 1ur5 C:2-143 [99809]
        Other proteins in same PDB: d1ur5a2, d1ur5c2
        complexed with cd, cl, na, nad; mutant
    3. Domains for 1uxg:
      1. 821656Domain d1uxga1: 1uxg A:2-143 [108100]
        Other proteins in same PDB: d1uxga2, d1uxgb2
      2. 821657Domain d1uxgb1: 1uxg B:2-143 [108102]
        Other proteins in same PDB: d1uxga2, d1uxgb2
        complexed with fmr, nad; mutant
    4. Domains for 1uxh:
      1. 821658Domain d1uxha1: 1uxh A:2-143 [108104]
        Other proteins in same PDB: d1uxha2, d1uxhb2
      2. 821659Domain d1uxhb1: 1uxh B:2-143 [108106]
        Other proteins in same PDB: d1uxha2, d1uxhb2
        complexed with fmr, nad; mutant
    5. Domains for 1uxi:
      1. 821660Domain d1uxia1: 1uxi A:2-143 [108108]
        Other proteins in same PDB: d1uxia2, d1uxib2
      2. 821661Domain d1uxib1: 1uxi B:2-143 [108110]
        Other proteins in same PDB: d1uxia2, d1uxib2
        complexed with fmr, na, nad; mutant
    6. Domains for 1uxj:
      1. 821648Domain d1uxja1: 1uxj A:2-143 [108112]
        Other proteins in same PDB: d1uxja2, d1uxjc2
      2. 821649Domain d1uxjc1: 1uxj C:2-143 [108114]
        Other proteins in same PDB: d1uxja2, d1uxjc2
        complexed with cd, cl, na, nad; mutant
    7. Domains for 1uxk:
      1. 821652Domain d1uxka1: 1uxk A:2-143 [108116]
        Other proteins in same PDB: d1uxka2, d1uxkc2
      2. 821653Domain d1uxkc1: 1uxk C:2-143 [108118]
        Other proteins in same PDB: d1uxka2, d1uxkc2
        complexed with cd, cl, na, nad; mutant
  7. 821662Escherichia coli [TaxId:562] [51853] (5 PDB entries)
    1. Domain for 1emd:
    2. Domains for 1ib6:
      1. 821665Domain d1ib6a1: 1ib6 A:1-145 [62146]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      2. 821666Domain d1ib6b1: 1ib6 B:1-145 [62148]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      3. 821667Domain d1ib6c1: 1ib6 C:1-145 [62150]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      4. 821668Domain d1ib6d1: 1ib6 D:1-145 [62152]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
        complexed with nad, so4; mutant
    3. Domains for 1ie3:
      1. 821673Domain d1ie3a1: 1ie3 A:1-145 [62304]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      2. 821674Domain d1ie3b1: 1ie3 B:1-145 [62306]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      3. 821675Domain d1ie3c1: 1ie3 C:1-145 [62308]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      4. 821676Domain d1ie3d1: 1ie3 D:1-145 [62310]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
        complexed with nad, pyr; mutant
    4. Domain for 2cmd:
    5. Domains for 2pwz:
      1. 821669Domain d2pwza1: 2pwz A:1-145 [139766]
        Other proteins in same PDB: d2pwza2, d2pwzc2, d2pwze2, d2pwzg2
        automatically matched to d1emd_1
      2. 821670Domain d2pwzc1: 2pwz C:1-145 [139768]
        Other proteins in same PDB: d2pwza2, d2pwzc2, d2pwze2, d2pwzg2
        automatically matched to d1emd_1
      3. 821671Domain d2pwze1: 2pwz E:1-145 [139770]
        Other proteins in same PDB: d2pwza2, d2pwzc2, d2pwze2, d2pwzg2
        automatically matched to d1emd_1
      4. 821672Domain d2pwzg1: 2pwz G:1-145 [139772]
        Other proteins in same PDB: d2pwza2, d2pwzc2, d2pwze2, d2pwzg2
        automatically matched to d1emd_1
  8. 821677Flaveria bidentis, chloroplast [TaxId:4224] [51852] (1 PDB entry)
  9. 821679Pig (Sus scrofa) [TaxId:9823] [51850] (3 PDB entries)
    1. Domains for 1mld:
      1. 821680Domain d1mlda1: 1mld A:1-144 [30122]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      2. 821681Domain d1mldb1: 1mld B:1-144 [30123]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      3. 821682Domain d1mldc1: 1mld C:1-144 [30124]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      4. 821683Domain d1mldd1: 1mld D:1-144 [30125]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
        complexed with cit
    2. Domains for 4mdh:
      1. 821686Domain d4mdha1: 4mdh A:1-154 [30128]
        Other proteins in same PDB: d4mdha2, d4mdhb2
      2. 821687Domain d4mdhb1: 4mdh B:1-154 [30129]
        Other proteins in same PDB: d4mdha2, d4mdhb2
        complexed with nad, sul
    3. Domains for 5mdh:
      1. 821684Domain d5mdha1: 5mdh A:1-154 [30126]
        Other proteins in same PDB: d5mdha2, d5mdhb2
      2. 821685Domain d5mdhb1: 5mdh B:1-154 [30127]
        Other proteins in same PDB: d5mdha2, d5mdhb2
        complexed with mak, nad
  10. 821688Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [51851] (1 PDB entry)
  11. 821693Thermus flavus [TaxId:274] [51854] (2 PDB entries)
    1. Domains for 1bdm:
      1. 821694Domain d1bdma1: 1bdm A:0-154 [30137]
        Other proteins in same PDB: d1bdma2, d1bdmb2
      2. 821695Domain d1bdmb1: 1bdm B:0-154 [30138]
        Other proteins in same PDB: d1bdma2, d1bdmb2
        complexed with nax; mutant
    2. Domains for 1bmd:
      1. 821696Domain d1bmda1: 1bmd A:0-154 [30139]
        Other proteins in same PDB: d1bmda2, d1bmdb2
      2. 821697Domain d1bmdb1: 1bmd B:0-154 [30140]
        Other proteins in same PDB: d1bmda2, d1bmdb2
        complexed with nad
  12. 821698Thermus thermophilus [TaxId:274] [82300] (5 PDB entries)
    identical sequence to that from the Thermus flavus enzyme
    1. Domains for 1iz9:
      1. 821705Domain d1iz9a1: 1iz9 A:1-154 [76984]
        Other proteins in same PDB: d1iz9a2, d1iz9b2
      2. 821706Domain d1iz9b1: 1iz9 B:1-154 [76986]
        Other proteins in same PDB: d1iz9a2, d1iz9b2
    2. Domains for 1wze:
      1. 821701Domain d1wzea1: 1wze A:0-153 [121495]
        Other proteins in same PDB: d1wzea2, d1wzeb2
        automatically matched to d1iz9a1
        complexed with nad; mutant
      2. 821702Domain d1wzeb1: 1wze B:0-153 [121497]
        Other proteins in same PDB: d1wzea2, d1wzeb2
        automatically matched to d1iz9a1
        complexed with nad; mutant
    3. Domains for 1wzi:
      1. 821703Domain d1wzia1: 1wzi A:0-153 [121503]
        Other proteins in same PDB: d1wzia2, d1wzib2
        automatically matched to d1iz9a1
        complexed with ndp; mutant
      2. 821704Domain d1wzib1: 1wzi B:0-153 [121505]
        Other proteins in same PDB: d1wzia2, d1wzib2
        automatically matched to d1iz9a1
        complexed with ndp; mutant
    4. Domains for 1y7t:
      1. 821699Domain d1y7ta1: 1y7t A:0-153 [122718]
        Other proteins in same PDB: d1y7ta2, d1y7tb2
        automatically matched to d1iz9a1
        complexed with ndp, trs
      2. 821700Domain d1y7tb1: 1y7t B:0-153 [122720]
        Other proteins in same PDB: d1y7ta2, d1y7tb2
        automatically matched to d1iz9a1
        complexed with ndp, trs
    5. Domains for 2cvq:
      1. 821707Domain d2cvqa1: 2cvq A:0-153 [130885]
        Other proteins in same PDB: d2cvqa2, d2cvqb2
        automatically matched to d1iz9a1
        complexed with nap, trs
      2. 821708Domain d2cvqb1: 2cvq B:0-153 [130887]
        Other proteins in same PDB: d2cvqa2, d2cvqb2
        automatically matched to d1iz9a1
        complexed with nap, trs

More info for Protein Malate dehydrogenase from c.2.1.5: LDH N-terminal domain-like

Timeline for Protein Malate dehydrogenase from c.2.1.5: LDH N-terminal domain-like: