Lineage for Protein: Malate dehydrogenase

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 238223Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 238224Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families) (S)
  5. 239087Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain [51848] (4 proteins)
  6. 239148Protein Malate dehydrogenase [51849] (11 species)

Species:

  1. 239149Aquaspirillum arcticum [TaxId:87645] [51856] (3 PDB entries)
    1. Domain for 1b8p:
    2. Domain for 1b8u:
    3. Domain for 1b8v:
  2. 239153Archaeon Haloarcula marismortui [TaxId:2238] [51855] (5 PDB entries)
    1. Domains for 1d3a:
      1. 239160Domain d1d3aa1: 1d3a A:22-162 [30143]
        Other proteins in same PDB: d1d3aa2, d1d3ab2
      2. 239161Domain d1d3ab1: 1d3a B:22-162 [30144]
        Other proteins in same PDB: d1d3aa2, d1d3ab2
        complexed with cl, na
    2. Domains for 1gt2:
      1. 239162Domain d1gt2a1: 1gt2 A:22-162 [76338]
        Other proteins in same PDB: d1gt2a2, d1gt2b2
      2. 239163Domain d1gt2b1: 1gt2 B:22-162 [76340]
        Other proteins in same PDB: d1gt2a2, d1gt2b2
        complexed with cl, na, nad; mutant
    3. Domains for 1hlp:
      1. 239164Domain d1hlpa1: 1hlp A:21-162 [30145]
        Other proteins in same PDB: d1hlpa2, d1hlpb2
      2. 239165Domain d1hlpb1: 1hlp B:21-162 [30146]
        Other proteins in same PDB: d1hlpa2, d1hlpb2
        complexed with nad
    4. Domains for 1o6z:
      1. 239154Domain d1o6za1: 1o6z A:22-162 [81107]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      2. 239155Domain d1o6zb1: 1o6z B:22-162 [81109]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      3. 239156Domain d1o6zc1: 1o6z C:22-162 [81111]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
      4. 239157Domain d1o6zd1: 1o6z D:22-162 [81113]
        Other proteins in same PDB: d1o6za2, d1o6zb2, d1o6zc2, d1o6zd2
        complexed with cl, nad; mutant
    5. Domains for 2hlp:
      1. 239158Domain d2hlpa1: 2hlp A:22-162 [30141]
        Other proteins in same PDB: d2hlpa2, d2hlpb2
      2. 239159Domain d2hlpb1: 2hlp B:22-162 [30142]
        Other proteins in same PDB: d2hlpa2, d2hlpb2
  3. 239166Chlorobium tepidum [TaxId:1097] [69416] (1 PDB entry)
  4. 239169Chlorobium vibrioforme [TaxId:1098] [69417] (2 PDB entries)
    1. Domains for 1guz:
      1. 239170Domain d1guza1: 1guz A:1-142 [65586]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      2. 239171Domain d1guzb1: 1guz B:1-142 [65588]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      3. 239172Domain d1guzc1: 1guz C:1-142 [65590]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
      4. 239173Domain d1guzd1: 1guz D:1-142 [65592]
        Other proteins in same PDB: d1guza2, d1guzb2, d1guzc2, d1guzd2
        complexed with nad
    2. Domains for 1gv1:
      1. 239174Domain d1gv1a1: 1gv1 A:1-142 [65598]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      2. 239175Domain d1gv1b1: 1gv1 B:1-142 [65600]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      3. 239176Domain d1gv1c1: 1gv1 C:1-142 [65602]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
      4. 239177Domain d1gv1d1: 1gv1 D:1-142 [65604]
        Other proteins in same PDB: d1gv1a2, d1gv1b2, d1gv1c2, d1gv1d2
  5. 239178Chloroflexus aurantiacus [69415] (1 PDB entry)
  6. 239181Escherichia coli [TaxId:562] [51853] (4 PDB entries)
    1. Domain for 1emd:
    2. Domains for 1ib6:
      1. 239184Domain d1ib6a1: 1ib6 A:1-145 [62146]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      2. 239185Domain d1ib6b1: 1ib6 B:1-145 [62148]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      3. 239186Domain d1ib6c1: 1ib6 C:1-145 [62150]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
      4. 239187Domain d1ib6d1: 1ib6 D:1-145 [62152]
        Other proteins in same PDB: d1ib6a2, d1ib6b2, d1ib6c2, d1ib6d2
        complexed with nad, so4; mutant
    3. Domains for 1ie3:
      1. 239188Domain d1ie3a1: 1ie3 A:1-145 [62304]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      2. 239189Domain d1ie3b1: 1ie3 B:1-145 [62306]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      3. 239190Domain d1ie3c1: 1ie3 C:1-145 [62308]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
      4. 239191Domain d1ie3d1: 1ie3 D:1-145 [62310]
        Other proteins in same PDB: d1ie3a2, d1ie3b2, d1ie3c2, d1ie3d2
        complexed with nad, pyr; mutant
    4. Domain for 2cmd:
  7. 239192Flaveria bidentis, chloroplast [TaxId:4224] [51852] (1 PDB entry)
  8. 239194Pig (Sus scrofa) [TaxId:9823] [51850] (3 PDB entries)
    1. Domains for 1mld:
      1. 239195Domain d1mlda1: 1mld A:1-144 [30122]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      2. 239196Domain d1mldb1: 1mld B:1-144 [30123]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      3. 239197Domain d1mldc1: 1mld C:1-144 [30124]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
      4. 239198Domain d1mldd1: 1mld D:1-144 [30125]
        Other proteins in same PDB: d1mlda2, d1mldb2, d1mldc2, d1mldd2
        complexed with cit
    2. Domains for 4mdh:
      1. 239201Domain d4mdha1: 4mdh A:1-154 [30128]
        Other proteins in same PDB: d4mdha2, d4mdhb2
      2. 239202Domain d4mdhb1: 4mdh B:1-154 [30129]
        Other proteins in same PDB: d4mdha2, d4mdhb2
        complexed with nad, sul
    3. Domains for 5mdh:
      1. 239199Domain d5mdha1: 5mdh A:1-154 [30126]
        Other proteins in same PDB: d5mdha2, d5mdhb2
      2. 239200Domain d5mdhb1: 5mdh B:1-154 [30127]
        Other proteins in same PDB: d5mdha2, d5mdhb2
        complexed with mak, nad
  9. 239203Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [51851] (1 PDB entry)
  10. 239208Thermus flavus [TaxId:274] [51854] (2 PDB entries)
    1. Domains for 1bdm:
      1. 239209Domain d1bdma1: 1bdm A:0-154 [30137]
        Other proteins in same PDB: d1bdma2, d1bdmb2
      2. 239210Domain d1bdmb1: 1bdm B:0-154 [30138]
        Other proteins in same PDB: d1bdma2, d1bdmb2
        complexed with nax; mutant
    2. Domains for 1bmd:
      1. 239211Domain d1bmda1: 1bmd A:0-154 [30139]
        Other proteins in same PDB: d1bmda2, d1bmdb2
      2. 239212Domain d1bmdb1: 1bmd B:0-154 [30140]
        Other proteins in same PDB: d1bmda2, d1bmdb2
        complexed with nad
  11. 239213Thermus thermophilus [TaxId:274] [82300] (1 PDB entry)
    identical sequence to that from the Thermus flavus enzyme

More info for Protein Malate dehydrogenase from c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain

Timeline for Protein Malate dehydrogenase from c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain: