SCOPe 2.04: Family c.2.1.5: LDH N-terminal domain-like

Lineage for Family c.2.1.5: LDH N-terminal domain-like

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.5: LDH N-terminal domain-like [51848] (9 proteins)

Proteins:

1. 6-phospho-beta-glucosidase [110428] (2 species)

   1. Species Bacillus stearothermophilus [TaxId:1422] [110429] (1 PDB entry)
      Uniprot P84135

   2. Species Thermotoga maritima [TaxId:2336] [110430] (3 PDB entries)
      Uniprot Q9X108

2. Alpha-glucosidase AglA [89530] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [89531] (1 PDB entry)
     TM1834

3. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [51857] (1 species)

   • Species Lactobacillus confusus [TaxId:1583] [51858] (1 PDB entry)

4. Lactate dehydrogenase [51859] (18 species)

   1. Species Bacillus stearothermophilus [TaxId:1422] [51864] (3 PDB entries)

   2. Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [51866] (2 PDB entries)

   3. Species Clostridium thermocellum [TaxId:1515] [117432] (1 PDB entry)
      Uniprot Q4CDK5

   4. Species Cryptosporidium parvum [TaxId:5807] [225185] (4 PDB entries)

   5. Species Dogfish (Squalus acanthias) [TaxId:7797] [51862] (3 PDB entries)

   6. Species Homo sapiens [TaxId:9606] [256976] (1 PDB entry)

   7. Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [63939] (2 PDB entries)

   8. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (7 PDB entries)

   9. Species Lactobacillus casei [TaxId:1582] [51865] (6 PDB entries)

   10. Species Lactobacillus pentosus [TaxId:1589] [69418] (1 PDB entry)

   11. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51863] (13 PDB entries)

   12. Species Mouse (Mus musculus) [TaxId:10090] [51861] (1 PDB entry)

   13. Species Pig (Sus scrofa) [TaxId:9823] [51860] (3 PDB entries)

   14. Species Plasmodium berghei [TaxId:5821] [102165] (1 PDB entry)

   15. Species Plasmodium vivax [TaxId:5855] [225043] (2 PDB entries)

   16. Species Thermotoga maritima [TaxId:2336] [51867] (1 PDB entry)

   17. Species Thermus caldophilus [TaxId:272] [226614] (2 PDB entries)

   18. Species Toxoplasma gondii [TaxId:5811] [102166] (5 PDB entries)

5. Malate dehydrogenase [51849] (13 species)

   1. Species Aquaspirillum arcticum [TaxId:87645] [51856] (3 PDB entries)

   2. Species Archaeoglobus fulgidus [TaxId:2234] [110427] (2 PDB entries)
      Uniprot O08349

   3. Species Chlorobium tepidum [TaxId:1097] [69416] (1 PDB entry)

   4. Species Chlorobium vibrioforme [TaxId:1098] [69417] (2 PDB entries)

   5. Species Chloroflexus aurantiacus [TaxId:1108] [69415] (7 PDB entries)
      Uniprot P80040

   6. Species Chloroflexus sp. [TaxId:480224] [236527] (1 PDB entry)

   7. Species Escherichia coli [TaxId:562] [51853] (4 PDB entries)

   8. Species Flaveria bidentis, chloroplast [TaxId:4224] [51852] (1 PDB entry)

   9. Species Haloarcula marismortui [TaxId:2238] [51855] (5 PDB entries)

   10. Species Pig (Sus scrofa) [TaxId:9823] [51850] (3 PDB entries)

   11. Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [51851] (1 PDB entry)

   12. Species Thermus flavus [TaxId:274] [51854] (2 PDB entries)

   13. Species Thermus thermophilus [TaxId:274] [82300] (7 PDB entries)
       identical sequence to that from the Thermus flavus enzyme

6. Maltose-6'-phosphate glucosidase GlvA [102169] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [102170] (1 PDB entry)
     Uniprot P54716

7. MJ0490, lactate/malate dehydrogenase [63941] (1 species)

   • Species Methanococcus jannaschii [TaxId:2190] [63942] (2 PDB entries)

8. Putative alpha-glucosidase TM0752 [102167] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [102168] (1 PDB entry)

9. automated matches [226881] (6 species)
   not a true protein

   1. Species Cryptosporidium parvum [TaxId:353152] [261793] (5 PDB entries)

   2. Species Haloarcula marismortui [TaxId:2238] [225147] (4 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [225056] (1 PDB entry)

   4. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [254908] (5 PDB entries)

   5. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [225718] (5 PDB entries)

   6. Species Toxoplasma gondii [TaxId:5811] [233099] (1 PDB entry)

More info for Family c.2.1.5: LDH N-terminal domain-like

Timeline for Family c.2.1.5: LDH N-terminal domain-like:

• Family c.2.1.5: LDH N-terminal domain-like first appeared (with stable ids) in SCOP 1.55, called Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain
  
• Family c.2.1.5: LDH N-terminal domain-like appears in SCOPe 2.03
  
• Family c.2.1.5: LDH N-terminal domain-like appears in SCOPe 2.05
  
• Family c.2.1.5: LDH N-terminal domain-like appears in the current release, SCOPe 2.08