SCOPe 2.01: Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

Lineage for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 proteins)
   this domain interrupts the other domain which defines family

Proteins:

1. D-2-hydroxyisocaproate dehydrogenase [51835] (1 species)

   • Species Lactobacillus casei [TaxId:1582] [51836] (1 PDB entry)

2. D-glycerate dehydrogenase [51837] (1 species)

   • Species Hyphomicrobium methylovorum [TaxId:84] [51838] (1 PDB entry)

3. D-lactate dehydrogenase [51841] (1 species)

   • Species Lactobacillus helveticus [TaxId:1587] [51842] (3 PDB entries)

4. Formate dehydrogenase [51831] (1 species)

   • Species Pseudomonas sp., strain 101 [TaxId:306] [51832] (2 PDB entries)

5. L-alanine dehydrogenase [51843] (1 species)

   • Species Phormidium lapideum [TaxId:32060] [51844] (3 PDB entries)

6. Nicotinamide nucleotide transhydrogenase dI component [63937] (1 species)
   L-alanine dehydrogenase homologue

   • Species Rhodospirillum rubrum [TaxId:1085] [63938] (15 PDB entries)

7. Phosphoglycerate dehydrogenase [51839] (2 species)
   has additional C-terminal domain of the ferredoxin fold

   1. Species Escherichia coli [TaxId:562] [51840] (7 PDB entries)

   2. Species Mycobacterium tuberculosis [TaxId:1773] [141927] (1 PDB entry)
      Uniprot P0A544 98-281

8. Putative formate dehydrogenase [51833] (1 species)

   • Species Pyrobaculum aerophilum [TaxId:13773] [51834] (1 PDB entry)

9. S-adenosylhomocystein hydrolase [51845] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [51846] (2 PDB entries)

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [51847] (7 PDB entries)

   3. Species Plasmodium falciparum, isolate 3D7 [TaxId:5833] [117431] (1 PDB entry)
      Uniprot P50250

10. Transcription corepressor CtbP [82298] (2 species)
    C-terminal binding protein 1; a dehydrogenase

    1. Species Human (Homo sapiens), Ctbp1 [TaxId:9606] [82299] (1 PDB entry)

    2. Species Rat (Rattus norvegicus), Ctbp3 [TaxId:10116] [89529] (2 PDB entries)

More info for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

Timeline for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain:

• Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain appears in SCOP 1.75
  
• Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain appears in SCOPe 2.02
  
• Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain appears in the current release, SCOPe 2.08