Lineage for Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 238223Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 238224Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families) (S)
  5. 238741Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (12 proteins)
    family members also share a common alpha+beta fold in C-terminal domain
  6. 238834Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801] (13 species)

Species:

  1. 238835Archaeon Methanothermus fervidus [TaxId:2180] [51807] (1 PDB entry)
  2. 238840Archaeon Sulfolobus solfataricus [TaxId:2287] [51806] (1 PDB entry)
  3. 238843Bacillus stearothermophilus, nca 1503 [TaxId:1422] [51803] (6 PDB entries)
    1. Domains for 1dbv:
      1. 238848Domain d1dbvo1: 1dbv O:0-148,O:313-333 [29966]
        Other proteins in same PDB: d1dbvo2, d1dbvp2, d1dbvq2, d1dbvr2
      2. 238849Domain d1dbvp1: 1dbv P:0-148,P:313-333 [29967]
        Other proteins in same PDB: d1dbvo2, d1dbvp2, d1dbvq2, d1dbvr2
      3. 238850Domain d1dbvq1: 1dbv Q:0-148,Q:313-333 [29968]
        Other proteins in same PDB: d1dbvo2, d1dbvp2, d1dbvq2, d1dbvr2
      4. 238851Domain d1dbvr1: 1dbv R:0-148,R:313-333 [29969]
        Other proteins in same PDB: d1dbvo2, d1dbvp2, d1dbvq2, d1dbvr2
        complexed with nad, so4; mutant
    2. Domains for 1gd1:
      1. 238844Domain d1gd1o1: 1gd1 O:0-148,O:313-333 [29962]
        Other proteins in same PDB: d1gd1o2, d1gd1p2, d1gd1q2, d1gd1r2
      2. 238845Domain d1gd1p1: 1gd1 P:0-148,P:313-333 [29963]
        Other proteins in same PDB: d1gd1o2, d1gd1p2, d1gd1q2, d1gd1r2
      3. 238846Domain d1gd1q1: 1gd1 Q:0-148,Q:313-333 [29964]
        Other proteins in same PDB: d1gd1o2, d1gd1p2, d1gd1q2, d1gd1r2
      4. 238847Domain d1gd1r1: 1gd1 R:0-148,R:313-333 [29965]
        Other proteins in same PDB: d1gd1o2, d1gd1p2, d1gd1q2, d1gd1r2
        complexed with nad, so4
    3. Domains for 2dbv:
      1. 238852Domain d2dbvo1: 2dbv O:0-148,O:313-333 [29970]
        Other proteins in same PDB: d2dbvo2, d2dbvp2, d2dbvq2, d2dbvr2
      2. 238853Domain d2dbvp1: 2dbv P:0-148,P:313-333 [29971]
        Other proteins in same PDB: d2dbvo2, d2dbvp2, d2dbvq2, d2dbvr2
      3. 238854Domain d2dbvq1: 2dbv Q:0-148,Q:313-333 [29972]
        Other proteins in same PDB: d2dbvo2, d2dbvp2, d2dbvq2, d2dbvr2
      4. 238855Domain d2dbvr1: 2dbv R:0-148,R:313-333 [29973]
        Other proteins in same PDB: d2dbvo2, d2dbvp2, d2dbvq2, d2dbvr2
        complexed with ndp, so4; mutant
    4. Domains for 2gd1:
      1. 238860Domain d2gd1o1: 2gd1 O:0-148,O:313-333 [29978]
        Other proteins in same PDB: d2gd1o2, d2gd1p2, d2gd1q2, d2gd1r2
      2. 238861Domain d2gd1p1: 2gd1 P:0-148,P:313-333 [29979]
        Other proteins in same PDB: d2gd1o2, d2gd1p2, d2gd1q2, d2gd1r2
      3. 238862Domain d2gd1q1: 2gd1 Q:0-148,Q:313-333 [29980]
        Other proteins in same PDB: d2gd1o2, d2gd1p2, d2gd1q2, d2gd1r2
      4. 238863Domain d2gd1r1: 2gd1 R:0-148,R:313-333 [29981]
        Other proteins in same PDB: d2gd1o2, d2gd1p2, d2gd1q2, d2gd1r2
        complexed with so4
    5. Domains for 3dbv:
      1. 238864Domain d3dbvo1: 3dbv O:0-148,O:313-333 [29982]
        Other proteins in same PDB: d3dbvo2, d3dbvp2, d3dbvq2, d3dbvr2
      2. 238865Domain d3dbvp1: 3dbv P:0-148,P:313-333 [29983]
        Other proteins in same PDB: d3dbvo2, d3dbvp2, d3dbvq2, d3dbvr2
      3. 238866Domain d3dbvq1: 3dbv Q:0-148,Q:313-333 [29984]
        Other proteins in same PDB: d3dbvo2, d3dbvp2, d3dbvq2, d3dbvr2
      4. 238867Domain d3dbvr1: 3dbv R:0-148,R:313-333 [29985]
        Other proteins in same PDB: d3dbvo2, d3dbvp2, d3dbvq2, d3dbvr2
        complexed with nad, so4; mutant
    6. Domains for 4dbv:
      1. 238856Domain d4dbvo1: 4dbv O:0-148,O:313-333 [29974]
        Other proteins in same PDB: d4dbvo2, d4dbvp2, d4dbvq2, d4dbvr2
      2. 238857Domain d4dbvp1: 4dbv P:0-148,P:313-333 [29975]
        Other proteins in same PDB: d4dbvo2, d4dbvp2, d4dbvq2, d4dbvr2
      3. 238858Domain d4dbvq1: 4dbv Q:0-148,Q:313-333 [29976]
        Other proteins in same PDB: d4dbvo2, d4dbvp2, d4dbvq2, d4dbvr2
      4. 238859Domain d4dbvr1: 4dbv R:0-148,R:313-333 [29977]
        Other proteins in same PDB: d4dbvo2, d4dbvp2, d4dbvq2, d4dbvr2
        complexed with ndp, so4; mutant
  4. 238868Escherichia coli [TaxId:562] [51802] (6 PDB entries)
    1. Domains for 1dc3:
      1. 238877Domain d1dc3a1: 1dc3 A:0-148,A:313-330 [29958]
        Other proteins in same PDB: d1dc3a2, d1dc3b2
      2. 238878Domain d1dc3b1: 1dc3 B:0-148,B:313-330 [29959]
        Other proteins in same PDB: d1dc3a2, d1dc3b2
    2. Domains for 1dc4:
      1. 238879Domain d1dc4a1: 1dc4 A:0-148,A:313-330 [29960]
        Other proteins in same PDB: d1dc4a2, d1dc4b2
      2. 238880Domain d1dc4b1: 1dc4 B:0-148,B:313-330 [29961]
        Other proteins in same PDB: d1dc4a2, d1dc4b2
        complexed with g3h
    3. Domains for 1dc5:
      1. 238871Domain d1dc5a1: 1dc5 A:0-148,A:313-330 [29952]
        Other proteins in same PDB: d1dc5a2, d1dc5b2
      2. 238872Domain d1dc5b1: 1dc5 B:0-148,B:313-330 [29953]
        Other proteins in same PDB: d1dc5a2, d1dc5b2
    4. Domains for 1dc6:
      1. 238873Domain d1dc6a1: 1dc6 A:0-148,A:313-330 [29956]
        Other proteins in same PDB: d1dc6a2, d1dc6b2
      2. 238874Domain d1dc6b1: 1dc6 B:0-148,B:313-330 [29957]
        Other proteins in same PDB: d1dc6a2, d1dc6b2
        complexed with nad
    5. Domains for 1gad:
      1. 238869Domain d1gado1: 1gad O:0-148,O:313-330 [29950]
        Other proteins in same PDB: d1gado2, d1gadp2
      2. 238870Domain d1gadp1: 1gad P:0-148,P:313-330 [29951]
        Other proteins in same PDB: d1gado2, d1gadp2
        complexed with nad
    6. Domains for 1gae:
      1. 238875Domain d1gaeo1: 1gae O:0-148,O:313-330 [29954]
        Other proteins in same PDB: d1gaeo2, d1gaep2
      2. 238876Domain d1gaep1: 1gae P:0-148,P:313-330 [29955]
        Other proteins in same PDB: d1gaeo2, d1gaep2
        complexed with nad; mutant
  5. 238881Human (Homo sapiens) [TaxId:9606] [51812] (1 PDB entry)
  6. 238884Leishmania mexicana [TaxId:5665] [51809] (5 PDB entries)
    1. Domains for 1a7k:
      1. 238895Domain d1a7ka1: 1a7k A:1-165,A:335-358 [30008]
        Other proteins in same PDB: d1a7ka2, d1a7kb2, d1a7kc2, d1a7kd2
      2. 238896Domain d1a7kb1: 1a7k B:1-165,B:335-358 [30009]
        Other proteins in same PDB: d1a7ka2, d1a7kb2, d1a7kc2, d1a7kd2
      3. 238897Domain d1a7kc1: 1a7k C:1-165,C:335-358 [30010]
        Other proteins in same PDB: d1a7ka2, d1a7kb2, d1a7kc2, d1a7kd2
      4. 238898Domain d1a7kd1: 1a7k D:1-165,D:335-358 [30011]
        Other proteins in same PDB: d1a7ka2, d1a7kb2, d1a7kc2, d1a7kd2
        complexed with nad, po4
    2. Domains for 1gyp:
      1. 238891Domain d1gypa1: 1gyp A:1-165,A:335-358 [30004]
        Other proteins in same PDB: d1gypa2, d1gypb2, d1gypc2, d1gypd2
      2. 238892Domain d1gypb1: 1gyp B:1-165,B:335-358 [30005]
        Other proteins in same PDB: d1gypa2, d1gypb2, d1gypc2, d1gypd2
      3. 238893Domain d1gypc1: 1gyp C:1-165,C:335-358 [30006]
        Other proteins in same PDB: d1gypa2, d1gypb2, d1gypc2, d1gypd2
      4. 238894Domain d1gypd1: 1gyp D:1-165,D:335-358 [30007]
        Other proteins in same PDB: d1gypa2, d1gypb2, d1gypc2, d1gypd2
        complexed with nad, po4
    3. Domains for 1gyq:
      1. 238905Domain d1gyqa1: 1gyq A:1-165,A:335-358 [30012]
        Other proteins in same PDB: d1gyqa2, d1gyqb2, d1gyqc2, d1gyqd2
      2. 238906Domain d1gyqb1: 1gyq B:1-165,B:335-358 [30013]
        Other proteins in same PDB: d1gyqa2, d1gyqb2, d1gyqc2, d1gyqd2
      3. 238907Domain d1gyqc1: 1gyq C:1-165,C:335-358 [30014]
        Other proteins in same PDB: d1gyqa2, d1gyqb2, d1gyqc2, d1gyqd2
      4. 238908Domain d1gyqd1: 1gyq D:1-165,D:335-358 [30015]
        Other proteins in same PDB: d1gyqa2, d1gyqb2, d1gyqc2, d1gyqd2
        complexed with nbd
    4. Domains for 1i32:
      1. 238885Domain d1i32a1: 1i32 A:1-165,A:335-358 [65993]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
      2. 238886Domain d1i32b1: 1i32 B:1-165,B:335-358 [65995]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
      3. 238887Domain d1i32c1: 1i32 C:1-165,C:335-358 [65997]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
      4. 238888Domain d1i32d1: 1i32 D:1-165,D:335-358 [65999]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
      5. 238889Domain d1i32e1: 1i32 E:1-165,E:335-358 [66001]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
      6. 238890Domain d1i32f1: 1i32 F:1-165,F:335-358 [66003]
        Other proteins in same PDB: d1i32a2, d1i32b2, d1i32c2, d1i32d2, d1i32e2, d1i32f2
        complexed with nmd
    5. Domains for 1i33:
      1. 238899Domain d1i33a1: 1i33 A:1-165,A:335-358 [66005]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
      2. 238900Domain d1i33b1: 1i33 B:1-165,B:335-358 [66007]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
      3. 238901Domain d1i33c1: 1i33 C:1-165,C:335-358 [66009]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
      4. 238902Domain d1i33d1: 1i33 D:1-165,D:335-358 [66011]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
      5. 238903Domain d1i33e1: 1i33 E:1-165,E:335-358 [66013]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
      6. 238904Domain d1i33f1: 1i33 F:1-165,F:335-358 [66015]
        Other proteins in same PDB: d1i33a2, d1i33b2, d1i33c2, d1i33d2, d1i33e2, d1i33f2
        complexed with tnd
  7. 238909Lobster (Homarus americanus) [51810] (2 PDB entries)
    1. Domains for 1gpd:
      1. 238914Domain d1gpdg1: 1gpd G:1-148,G:313-334 [30020]
        Other proteins in same PDB: d1gpdg2, d1gpdr2
      2. 238915Domain d1gpdr1: 1gpd R:1-148,R:313-334 [30021]
        Other proteins in same PDB: d1gpdg2, d1gpdr2
        complexed with ips, nad, sps
    2. Domains for 4gpd:
      1. 238910Domain d4gpd11: 4gpd 1:1-147,1:312-333 [30016]
        Other proteins in same PDB: d4gpd12, d4gpd22, d4gpd32, d4gpd42
      2. 238911Domain d4gpd21: 4gpd 2:1-147,2:312-333 [30017]
        Other proteins in same PDB: d4gpd12, d4gpd22, d4gpd32, d4gpd42
      3. 238912Domain d4gpd31: 4gpd 3:1-147,3:312-333 [30018]
        Other proteins in same PDB: d4gpd12, d4gpd22, d4gpd32, d4gpd42
      4. 238913Domain d4gpd41: 4gpd 4:1-147,4:312-333 [30019]
        Other proteins in same PDB: d4gpd12, d4gpd22, d4gpd32, d4gpd42
  8. 238916Lobster (Palinurus versicolor) [51811] (5 PDB entries)
    1. Domains for 1crw:
      1. 238919Domain d1crwg1: 1crw G:1-148,G:313-334 [30026]
        Other proteins in same PDB: d1crwg2, d1crwr2
      2. 238920Domain d1crwr1: 1crw R:1-148,R:313-334 [30027]
        Other proteins in same PDB: d1crwg2, d1crwr2
    2. Domains for 1dss:
      1. 238917Domain d1dssg1: 1dss G:1-148,G:313-334 [30022]
        Other proteins in same PDB: d1dssg2, d1dssr2
      2. 238918Domain d1dssr1: 1dss R:1-148,R:313-334 [30023]
        Other proteins in same PDB: d1dssg2, d1dssr2
        complexed with nad, so4
    3. Domains for 1ihx:
      1. 238923Domain d1ihxa1: 1ihx A:1-148,A:313-334 [71211]
        Other proteins in same PDB: d1ihxa2, d1ihxb2, d1ihxc2, d1ihxd2
      2. 238924Domain d1ihxb1: 1ihx B:1-148,B:313-334 [71213]
        Other proteins in same PDB: d1ihxa2, d1ihxb2, d1ihxc2, d1ihxd2
      3. 238925Domain d1ihxc1: 1ihx C:1-148,C:313-334 [71215]
        Other proteins in same PDB: d1ihxa2, d1ihxb2, d1ihxc2, d1ihxd2
      4. 238926Domain d1ihxd1: 1ihx D:1-148,D:313-334 [71217]
        Other proteins in same PDB: d1ihxa2, d1ihxb2, d1ihxc2, d1ihxd2
        complexed with snd, so4
    4. Domains for 1ihy:
      1. 238927Domain d1ihya1: 1ihy A:1-148,A:313-334 [71219]
        Other proteins in same PDB: d1ihya2, d1ihyb2, d1ihyc2, d1ihyd2
      2. 238928Domain d1ihyb1: 1ihy B:1-148,B:313-334 [71221]
        Other proteins in same PDB: d1ihya2, d1ihyb2, d1ihyc2, d1ihyd2
      3. 238929Domain d1ihyc1: 1ihy C:1-148,C:313-334 [71223]
        Other proteins in same PDB: d1ihya2, d1ihyb2, d1ihyc2, d1ihyd2
      4. 238930Domain d1ihyd1: 1ihy D:1-148,D:313-334 [71225]
        Other proteins in same PDB: d1ihya2, d1ihyb2, d1ihyc2, d1ihyd2
        complexed with apr, so4
    5. Domains for 1szj:
      1. 238921Domain d1szjg1: 1szj G:1-148,G:313-334 [30024]
        Other proteins in same PDB: d1szjg2, d1szjr2
      2. 238922Domain d1szjr1: 1szj R:1-148,R:313-334 [30025]
        Other proteins in same PDB: d1szjg2, d1szjr2
        complexed with nad, so4
  9. 238931Spinach (Spinacia oleracea) [TaxId:3562] [69409] (1 PDB entry)
  10. 238935Thermotoga maritima [TaxId:243274] [51805] (1 PDB entry)
  11. 238938Thermus aquaticus [TaxId:271] [51804] (1 PDB entry)
  12. 238943Trypanosoma brucei brucei, glycosome [TaxId:5702] [51808] (1 PDB entry)
  13. 238950Trypanosoma cruzi [TaxId:5693] [75104] (1 PDB entry)

More info for Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain

Timeline for Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain:

  • Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain first appeared (with stable ids) in SCOP 1.55
  • Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain appears in SCOP 1.61
  • Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain appears in SCOP 1.65
  • Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain appears in the current release, SCOPe 2.07