Lineage for Protein: Enoyl-ACP reductase

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 975436Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 975885Protein Enoyl-ACP reductase [51791] (10 species)

Species:

  1. 975886Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
  2. 975888Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    1. Domains for 3oif:
      1. 975890Domain d3oifa_: 3oif A: [183048]
        automated match to d1lxca_
        complexed with nad, tcl
      2. 975891Domain d3oifb_: 3oif B: [183049]
        automated match to d1lxca_
        complexed with nad, tcl
      3. 975892Domain d3oifc_: 3oif C: [183050]
        automated match to d1lxca_
        complexed with nad, tcl
      4. 975893Domain d3oifd_: 3oif D: [183051]
        automated match to d1lxca_
        complexed with nad, tcl
    2. Domain for 3oig:
  3. 975894Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    1. Domains for 1c14:
      1. 975911Domain d1c14a_: 1c14 A: [29927]
        complexed with nad, tcl
      2. 975912Domain d1c14b_: 1c14 B: [29928]
        complexed with nad, tcl
    2. Domains for 1d8a:
      1. 975927Domain d1d8aa_: 1d8a A: [29931]
        complexed with nad, tcl
      2. 975928Domain d1d8ab_: 1d8a B: [29932]
        complexed with nad, tcl
    3. Domains for 1dfg:
      1. 975921Domain d1dfga_: 1dfg A: [29933]
        complexed with nad, ndt
      2. 975922Domain d1dfgb_: 1dfg B: [29934]
        complexed with nad, ndt
    4. Domains for 1dfh:
      1. 975913Domain d1dfha_: 1dfh A: [29929]
        complexed with nad, tdb
      2. 975914Domain d1dfhb_: 1dfh B: [29930]
        complexed with nad, tdb
    5. Domains for 1dfi:
      1. 975907Domain d1dfia_: 1dfi A: [29923]
        complexed with nad
      2. 975908Domain d1dfib_: 1dfi B: [29924]
        complexed with nad
      3. 975909Domain d1dfic_: 1dfi C: [29925]
        complexed with nad
      4. 975910Domain d1dfid_: 1dfi D: [29926]
        complexed with nad
    6. Domains for 1i2z:
      1. 975925Domain d1i2za_: 1i2z A: [65989]
        complexed with 654, nad
      2. 975926Domain d1i2zb_: 1i2z B: [65990]
        complexed with 654, nad
    7. Domains for 1i30:
      1. 975923Domain d1i30a_: 1i30 A: [65991]
        complexed with 826, nad
      2. 975924Domain d1i30b_: 1i30 B: [65992]
        complexed with 826, nad
    8. Domains for 1lx6:
      1. 975917Domain d1lx6a_: 1lx6 A: [78287]
        complexed with nad, zam
      2. 975918Domain d1lx6b_: 1lx6 B: [78288]
        complexed with nad, zam
    9. Domains for 1lxc:
      1. 975919Domain d1lxca_: 1lxc A: [78289]
        complexed with aym, nad
      2. 975920Domain d1lxcb_: 1lxc B: [78290]
        complexed with aym, nad
    10. Domains for 1mfp:
      1. 975915Domain d1mfpa_: 1mfp A: [84938]
        complexed with idn, nad, so4
      2. 975916Domain d1mfpb_: 1mfp B: [84939]
        complexed with idn, nad, so4
    11. Domains for 1qg6:
      1. 975903Domain d1qg6a_: 1qg6 A: [29919]
        complexed with nad, tcl
      2. 975904Domain d1qg6b_: 1qg6 B: [29920]
        complexed with nad, tcl
      3. 975905Domain d1qg6c_: 1qg6 C: [29921]
        complexed with nad, tcl
      4. 975906Domain d1qg6d_: 1qg6 D: [29922]
        complexed with nad, tcl
    12. Domains for 1qsg:
      1. 975895Domain d1qsga_: 1qsg A: [29935]
        complexed with glc, nad, tcl
      2. 975896Domain d1qsgb_: 1qsg B: [29936]
        complexed with glc, nad, tcl
      3. 975897Domain d1qsgc_: 1qsg C: [29937]
        complexed with glc, nad, tcl
      4. 975898Domain d1qsgd_: 1qsg D: [29938]
        complexed with glc, nad, tcl
      5. 975899Domain d1qsge_: 1qsg E: [29939]
        complexed with glc, nad, tcl
      6. 975900Domain d1qsgf_: 1qsg F: [29940]
        complexed with glc, nad, tcl
      7. 975901Domain d1qsgg_: 1qsg G: [29941]
        complexed with glc, nad, tcl
      8. 975902Domain d1qsgh_: 1qsg H: [29942]
        complexed with glc, nad, tcl
    13. Domains for 2fhs:
      1. 975929Domain d2fhsa_: 2fhs A: [133501]
        Other proteins in same PDB: d2fhsc_
        automated match to d1qsgg_
      2. 975930Domain d2fhsb_: 2fhs B: [133502]
        Other proteins in same PDB: d2fhsc_
        automated match to d1qsgg_
  4. 975931Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    1. Domains for 2pd3:
      1. 975936Domain d2pd3a_: 2pd3 A: [139656]
        automated match to d1jvfa_
        complexed with nad, tcl
      2. 975937Domain d2pd3b_: 2pd3 B: [139657]
        automated match to d1jvfa_
        complexed with nad, tcl
      3. 975938Domain d2pd3c_: 2pd3 C: [139658]
        automated match to d1jvfa_
        complexed with nad, tcl
      4. 975939Domain d2pd3d_: 2pd3 D: [139659]
        automated match to d1jvfa_
        complexed with nad, tcl
    2. Domains for 2pd4:
      1. 975932Domain d2pd4a_: 2pd4 A: [139660]
        automated match to d1jvfa_
        complexed with dcn, nad
      2. 975933Domain d2pd4b_: 2pd4 B: [139661]
        automated match to d1jvfa_
        complexed with dcn, nad
      3. 975934Domain d2pd4c_: 2pd4 C: [139662]
        automated match to d1jvfa_
        complexed with dcn, nad
      4. 975935Domain d2pd4d_: 2pd4 D: [139663]
        automated match to d1jvfa_
        complexed with dcn, nad
  5. 975940Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
    Uniprot Q9BJJ9 96-424 # fragment
    1. Domains for 1nhg:
      1. 975962Domain d1nhg.1: 1nhg A:,C: [80516]
        complexed with nad, tcl
      2. 975963Domain d1nhg.2: 1nhg B:,D: [80517]
        complexed with nad, tcl
    2. Domains for 1nhw:
      1. 975964Domain d1nhw.1: 1nhw A:,C: [80518]
        complexed with nad, tcc
      2. 975965Domain d1nhw.2: 1nhw B:,D: [80519]
        complexed with nad, tcc
    3. Domains for 1nnu:
      1. 975966Domain d1nnu.1: 1nnu A:,C: [80672]
        complexed with nad, tct
      2. 975967Domain d1nnu.2: 1nnu B:,D: [80673]
        complexed with nad, tct
    4. Domains for 1uh5:
      1. 975945Domain d1uh5a_: 1uh5 A: [107840]
        complexed with nad, tcl
      2. 975946Domain d1uh5b_: 1uh5 B: [107841]
        complexed with nad, tcl
    5. Domains for 1v35:
      1. 975959Domain d1v35a_: 1v35 A: [108301]
        complexed with nai
      2. 975960Domain d1v35b_: 1v35 B: [108302]
        complexed with nai
    6. Domain for 1vrw:
    7. Domains for 1zsn:
      1. 975980Domain d1zsna_: 1zsn A: [125608]
        automated match to d1uh5a_
        complexed with nad, tn2
      2. 975981Domain d1zsnb_: 1zsn B: [125609]
        automated match to d1uh5a_
        complexed with nad, tn2
    8. Domains for 1zw1:
      1. 975986Domain d1zw1a_: 1zw1 A: [125735]
        automated match to d1uh5a_
        complexed with nad, tn5
      2. 975987Domain d1zw1b_: 1zw1 B: [125736]
        automated match to d1uh5a_
        complexed with nad, tn5
    9. Domains for 1zxb:
      1. 975978Domain d1zxba_: 1zxb A: [125767]
        automated match to d1uh5a_
        complexed with nad, tn3
      2. 975979Domain d1zxbb_: 1zxb B: [125768]
        automated match to d1uh5a_
        complexed with nad, tn3
    10. Domains for 1zxl:
      1. 975984Domain d1zxla1: 1zxl A:97-425 [125782]
        automatically matched to 1VRW A:97-425
        complexed with jp1, nad
      2. 975985Domain d1zxlb1: 1zxl B:97-425 [125783]
        automatically matched to 1VRW A:97-425
        complexed with jp1, nad
    11. Domains for 2o2y:
      1. 975951Domain d2o2ya_: 2o2y A: [138894]
        automated match to d1uh5a_
        complexed with cl, nad, so4, tcl
      2. 975952Domain d2o2yb_: 2o2y B: [138895]
        automated match to d1uh5a_
        complexed with cl, nad, so4, tcl
      3. 975953Domain d2o2yc_: 2o2y C: [138896]
        automated match to d1uh5a_
        complexed with cl, nad, so4, tcl
      4. 975954Domain d2o2yd_: 2o2y D: [138897]
        automated match to d1uh5a_
        complexed with cl, nad, so4, tcl
    12. Domains for 2ol4:
      1. 975957Domain d2ol4a_: 2ol4 A: [148811]
        automated match to d1vrwa1
        complexed with jpn, nad
      2. 975958Domain d2ol4b_: 2ol4 B: [148812]
        automated match to d1vrwa1
        complexed with jpn, nad
    13. Domains for 2oos:
      1. 975949Domain d2oosa_: 2oos A: [148938]
        automated match to d1vrwa1
        complexed with jpj, nad
      2. 975950Domain d2oosb_: 2oos B: [148939]
        automated match to d1vrwa1
        complexed with jpj, nad
    14. Domains for 2op0:
      1. 975976Domain d2op0a_: 2op0 A: [148950]
        automated match to d1vrwa1
        complexed with 7pc, nad, so4
      2. 975977Domain d2op0b_: 2op0 B: [148951]
        automated match to d1vrwa1
        complexed with 7pc, nad, so4
    15. Domains for 2op1:
      1. 975974Domain d2op1a_: 2op1 A: [148952]
        automated match to d1vrwa1
        complexed with 8pc, nad
      2. 975975Domain d2op1b_: 2op1 B: [148953]
        automated match to d1vrwa1
        complexed with 8pc, nad
    16. Domains for 3am3:
      1. 975970Domain d3am3a_: 3am3 A: [172238]
        automated match to d1uh5a_
        complexed with nad, tcl; mutant
      2. 975971Domain d3am3b_: 3am3 B: [172239]
        automated match to d1uh5a_
        complexed with nad, tcl; mutant
    17. Domains for 3am4:
      1. 975968Domain d3am4a_: 3am4 A: [172240]
        automated match to d1uh5a_
        complexed with ft1, nad; mutant
      2. 975969Domain d3am4b_: 3am4 B: [172241]
        automated match to d1uh5a_
        complexed with ft1, nad; mutant
    18. Domains for 3am5:
      1. 975943Domain d3am5a_: 3am5 A: [172242]
        automated match to d1uh5a_
        complexed with nad, tcl; mutant
      2. 975944Domain d3am5b_: 3am5 B: [172243]
        automated match to d1uh5a_
        complexed with nad, tcl; mutant
    19. Domains for 3lsy:
      1. 975982Domain d3lsya_: 3lsy A: [180546]
        automated match to d1uh5a_
        complexed with ft0, nad
      2. 975983Domain d3lsyb_: 3lsy B: [180547]
        automated match to d1uh5a_
        complexed with ft0, nad
    20. Domains for 3lt0:
      1. 975941Domain d3lt0a_: 3lt0 A: [180548]
        automated match to d1uh5a_
        complexed with ft1, nad
      2. 975942Domain d3lt0b_: 3lt0 B: [180549]
        automated match to d1uh5a_
        complexed with ft1, nad
    21. Domains for 3lt1:
      1. 975955Domain d3lt1a_: 3lt1 A: [180550]
        automated match to d1uh5a_
        complexed with ft2, nad
      2. 975956Domain d3lt1b_: 3lt1 B: [180551]
        automated match to d1uh5a_
        complexed with ft2, nad
    22. Domains for 3lt2:
      1. 975972Domain d3lt2a_: 3lt2 A: [180552]
        automated match to d1uh5a_
        complexed with ft3, nad
      2. 975973Domain d3lt2b_: 3lt2 B: [180553]
        automated match to d1uh5a_
        complexed with ft3, nad
    23. Domains for 3lt4:
      1. 975947Domain d3lt4a_: 3lt4 A: [180554]
        automated match to d1uh5a_
        complexed with fb4, nad
      2. 975948Domain d3lt4b_: 3lt4 B: [180555]
        automated match to d1uh5a_
        complexed with fb4, nad
  6. 975988Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
  7. 975991Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (36 PDB entries)
    1. Domains for 1bvr:
      1. 976056Domain d1bvra_: 1bvr A: [29913]
        complexed with nad, tht
      2. 976057Domain d1bvrb_: 1bvr B: [29914]
        complexed with nad, tht
      3. 976058Domain d1bvrc_: 1bvr C: [29915]
        complexed with nad, tht
      4. 976059Domain d1bvrd_: 1bvr D: [29916]
        complexed with nad, tht
      5. 976060Domain d1bvre_: 1bvr E: [29917]
        complexed with nad, tht
      6. 976061Domain d1bvrf_: 1bvr F: [29918]
        complexed with nad, tht
    2. Domain for 1eny:
    3. Domain for 1enz:
    4. Domains for 1p44:
      1. 976046Domain d1p44a_: 1p44 A: [94076]
        complexed with geq, nad
      2. 976047Domain d1p44b_: 1p44 B: [94077]
        complexed with geq, nad
      3. 976048Domain d1p44c_: 1p44 C: [94078]
        complexed with geq, nad
      4. 976049Domain d1p44d_: 1p44 D: [94079]
        complexed with geq, nad
      5. 976050Domain d1p44e_: 1p44 E: [94080]
        complexed with geq, nad
      6. 976051Domain d1p44f_: 1p44 F: [94081]
        complexed with geq, nad
    5. Domains for 1p45:
      1. 976054Domain d1p45a_: 1p45 A: [94082]
        complexed with nad, tcl
      2. 976055Domain d1p45b_: 1p45 B: [94083]
        complexed with nad, tcl
    6. Domain for 1zid:
    7. Domain for 2aq8:
    8. Domain for 2aqh:
    9. Domain for 2aqi:
    10. Domain for 2aqk:
    11. Domains for 2b35:
      1. 976034Domain d2b35a_: 2b35 A: [127767]
        automated match to d1bvra_
        complexed with nad, tcl
      2. 976035Domain d2b35b_: 2b35 B: [127768]
        automated match to d1bvra_
        complexed with nad, tcl
      3. 976036Domain d2b35c_: 2b35 C: [127769]
        automated match to d1bvra_
        complexed with nad, tcl
      4. 976037Domain d2b35d_: 2b35 D: [127770]
        automated match to d1bvra_
        complexed with nad, tcl
      5. 976038Domain d2b35e_: 2b35 E: [127771]
        automated match to d1bvra_
        complexed with nad, tcl
      6. 976039Domain d2b35f_: 2b35 F: [127772]
        automated match to d1bvra_
        complexed with nad, tcl
    12. Domains for 2b36:
      1. 976062Domain d2b36a_: 2b36 A: [127773]
        automated match to d1bvra_
        complexed with 5pp, nad
      2. 976063Domain d2b36b_: 2b36 B: [127774]
        automated match to d1bvra_
        complexed with 5pp, nad
      3. 976064Domain d2b36c_: 2b36 C: [127775]
        automated match to d1bvra_
        complexed with 5pp, nad
      4. 976065Domain d2b36d_: 2b36 D: [127776]
        automated match to d1bvra_
        complexed with 5pp, nad
      5. 976066Domain d2b36e_: 2b36 E: [127777]
        automated match to d1bvra_
        complexed with 5pp, nad
      6. 976067Domain d2b36f_: 2b36 F: [127778]
        automated match to d1bvra_
        complexed with 5pp, nad
    13. Domains for 2b37:
      1. 976040Domain d2b37a_: 2b37 A: [127779]
        automated match to d1bvra_
        complexed with 8ps, nad
      2. 976041Domain d2b37b_: 2b37 B: [127780]
        automated match to d1bvra_
        complexed with 8ps, nad
      3. 976042Domain d2b37c_: 2b37 C: [127781]
        automated match to d1bvra_
        complexed with 8ps, nad
      4. 976043Domain d2b37d_: 2b37 D: [127782]
        automated match to d1bvra_
        complexed with 8ps, nad
      5. 976044Domain d2b37e_: 2b37 E: [127783]
        automated match to d1bvra_
        complexed with 8ps, nad
      6. 976045Domain d2b37f_: 2b37 F: [127784]
        automated match to d1bvra_
        complexed with 8ps, nad
    14. Domain for 2h7i:
    15. Domain for 2h7l:
    16. Domain for 2h7m:
    17. Domain for 2h7n:
    18. Domain for 2h7p:
    19. Domain for 2h9i:
    20. Domain for 2idz:
    21. Domain for 2ie0:
    22. Domain for 2ieb:
    23. Domains for 2ied:
      1. 976018Domain d2ieda_: 2ied A: [147643]
        automated match to d1bvra_
        mutant
      2. 976019Domain d2iedb_: 2ied B: [147644]
        automated match to d1bvra_
        mutant
      3. 976020Domain d2iedc_: 2ied C: [147645]
        automated match to d1bvra_
        mutant
      4. 976021Domain d2iedd_: 2ied D: [147646]
        automated match to d1bvra_
        mutant
    24. Domains for 2nsd:
      1. 976016Domain d2nsda_: 2nsd A: [148384]
        automated match to d1bvra_
        complexed with 4pi, nad
      2. 976017Domain d2nsdb_: 2nsd B: [148385]
        automated match to d1bvra_
        complexed with 4pi, nad
    25. Domains for 2ntj:
      1. 976032Domain d2ntja_: 2ntj A: [138581]
        automated match to d1eny__
        complexed with p1h
      2. 976033Domain d2ntjb_: 2ntj B: [138582]
        automated match to d1eny__
        complexed with p1h
    26. Domain for 2nv6:
    27. Domain for 2pr2:
    28. Domains for 2x22:
      1. 976007Domain d2x22a_: 2x22 A: [169811]
        automated match to d1bvra_
        complexed with dms, nad, tcu
      2. 976008Domain d2x22b_: 2x22 B: [169812]
        automated match to d1bvra_
        complexed with dms, nad, tcu
    29. Domains for 2x23:
      1. 975994Domain d2x23a_: 2x23 A: [169813]
        automated match to d1bvra_
        complexed with dms, nad, tcu
      2. 975995Domain d2x23b_: 2x23 B: [169814]
        automated match to d1bvra_
        complexed with dms, nad, tcu
      3. 975996Domain d2x23e_: 2x23 E: [169815]
        automated match to d1bvra_
        complexed with dms, nad, tcu
      4. 975997Domain d2x23g_: 2x23 G: [169816]
        automated match to d1bvra_
        complexed with dms, nad, tcu
    30. Domains for 3fne:
      1. 976010Domain d3fnea_: 3fne A: [175911]
        automated match to d1bvra_
        complexed with 8pc, nad
      2. 976011Domain d3fneb_: 3fne B: [175912]
        automated match to d1bvra_
        complexed with 8pc, nad
      3. 976012Domain d3fnec_: 3fne C: [175913]
        automated match to d1bvra_
        complexed with 8pc, nad
      4. 976013Domain d3fned_: 3fne D: [175914]
        automated match to d1bvra_
        complexed with 8pc, nad
    31. Domains for 3fnf:
      1. 976026Domain d3fnfa_: 3fnf A: [175915]
        automated match to d1bvra_
        complexed with jpm, nad
      2. 976027Domain d3fnfb_: 3fnf B: [175916]
        automated match to d1bvra_
        complexed with jpm, nad
      3. 976028Domain d3fnfc_: 3fnf C: [175917]
        automated match to d1bvra_
        complexed with jpm, nad
      4. 976029Domain d3fnfd_: 3fnf D: [175918]
        automated match to d1bvra_
        complexed with jpm, nad
    32. Domain for 3fng:
    33. Domain for 3fnh:
    34. Domain for 3oew:
    35. Domain for 3oey:
    36. Domain for 3of2:
  8. 976069Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    1. Domains for 1cwu:
      1. 976073Domain d1cwua_: 1cwu A: [29908]
        complexed with nad, tdb; mutant
      2. 976074Domain d1cwub_: 1cwu B: [29909]
        complexed with nad, tdb; mutant
    2. Domain for 1d7o:
    3. Domain for 1eno:
    4. Domain for 1enp:
  9. 976075Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    1. Domain for 3gns:
    2. Domain for 3gnt:
    3. Domains for 3gr6:
      1. 976076Domain d3gr6a_: 3gr6 A: [176926]
        automated match to d1ulua_
        complexed with nap, tcl
      2. 976077Domain d3gr6g_: 3gr6 G: [176927]
        automated match to d1ulua_
        complexed with nap, tcl
      3. 976078Domain d3gr6j_: 3gr6 J: [176928]
        automated match to d1ulua_
        complexed with nap, tcl
  10. 976081Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
    Uniprot Q5SLI9

More info for Protein Enoyl-ACP reductase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Enoyl-ACP reductase from c.2.1.2: Tyrosine-dependent oxidoreductases: