Lineage for Protein: Enoyl-ACP reductase

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 685975Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 685976Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 686289Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 686655Protein Enoyl-ACP reductase [51791] (6 species)

Species:

  1. 686656Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    1. Domains for 1c14:
      1. 686673Domain d1c14a_: 1c14 A: [29927]
      2. 686674Domain d1c14b_: 1c14 B: [29928]
        complexed with nad, tcl
    2. Domains for 1d8a:
      1. 686679Domain d1d8aa_: 1d8a A: [29931]
      2. 686680Domain d1d8ab_: 1d8a B: [29932]
    3. Domains for 1dfg:
      1. 686681Domain d1dfga_: 1dfg A: [29933]
      2. 686682Domain d1dfgb_: 1dfg B: [29934]
        complexed with nad, ndt
    4. Domains for 1dfh:
      1. 686675Domain d1dfha_: 1dfh A: [29929]
      2. 686676Domain d1dfhb_: 1dfh B: [29930]
        complexed with nad, tdb
    5. Domains for 1dfi:
      1. 686665Domain d1dfia_: 1dfi A: [29923]
      2. 686666Domain d1dfib_: 1dfi B: [29924]
      3. 686667Domain d1dfic_: 1dfi C: [29925]
      4. 686668Domain d1dfid_: 1dfi D: [29926]
        complexed with nad
    6. Domains for 1i2z:
      1. 686691Domain d1i2za_: 1i2z A: [65989]
      2. 686692Domain d1i2zb_: 1i2z B: [65990]
        complexed with 654, nad
    7. Domains for 1i30:
      1. 686689Domain d1i30a_: 1i30 A: [65991]
      2. 686690Domain d1i30b_: 1i30 B: [65992]
        complexed with 826, nad
    8. Domains for 1lx6:
      1. 686683Domain d1lx6a_: 1lx6 A: [78287]
      2. 686684Domain d1lx6b_: 1lx6 B: [78288]
        complexed with nad, zam
    9. Domains for 1lxc:
      1. 686687Domain d1lxca_: 1lxc A: [78289]
      2. 686688Domain d1lxcb_: 1lxc B: [78290]
        complexed with aym, nad
    10. Domains for 1mfp:
      1. 686685Domain d1mfpa_: 1mfp A: [84938]
      2. 686686Domain d1mfpb_: 1mfp B: [84939]
        complexed with idn, nad, so4
    11. Domains for 1qg6:
      1. 686669Domain d1qg6a_: 1qg6 A: [29919]
      2. 686670Domain d1qg6b_: 1qg6 B: [29920]
      3. 686671Domain d1qg6c_: 1qg6 C: [29921]
      4. 686672Domain d1qg6d_: 1qg6 D: [29922]
        complexed with nad, tcl
    12. Domains for 1qsg:
      1. 686657Domain d1qsga_: 1qsg A: [29935]
      2. 686658Domain d1qsgb_: 1qsg B: [29936]
      3. 686659Domain d1qsgc_: 1qsg C: [29937]
      4. 686660Domain d1qsgd_: 1qsg D: [29938]
      5. 686661Domain d1qsge_: 1qsg E: [29939]
      6. 686662Domain d1qsgf_: 1qsg F: [29940]
      7. 686663Domain d1qsgg_: 1qsg G: [29941]
      8. 686664Domain d1qsgh_: 1qsg H: [29942]
        complexed with glc, nad, tcs
    13. Domains for 2fhs:
      1. 686677Domain d2fhsa1: 2fhs A:2-259 [133501]
        Other proteins in same PDB: d2fhsc1
        automatically matched to d1qsgg_
      2. 686678Domain d2fhsb1: 2fhs B:2-259 [133502]
        Other proteins in same PDB: d2fhsc1
        automatically matched to d1qsgg_
  2. 686693Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    1. Domains for 2pd3:
      1. 686698Domain d2pd3a1: 2pd3 A:2-275 [139656]
        automatically matched to d1jvfa_
        complexed with nad, tcl
      2. 686699Domain d2pd3b1: 2pd3 B:2-275 [139657]
        automatically matched to d1jvfa_
        complexed with nad, tcl
      3. 686700Domain d2pd3c1: 2pd3 C:2-275 [139658]
        automatically matched to d1jvfa_
        complexed with nad, tcl
      4. 686701Domain d2pd3d1: 2pd3 D:2-275 [139659]
        automatically matched to d1jvfa_
        complexed with nad, tcl
    2. Domains for 2pd4:
      1. 686694Domain d2pd4a1: 2pd4 A:2-275 [139660]
        automatically matched to d1jvfa_
        complexed with dcn, nad
      2. 686695Domain d2pd4b1: 2pd4 B:2-275 [139661]
        automatically matched to d1jvfa_
        complexed with dcn, nad
      3. 686696Domain d2pd4c1: 2pd4 C:2-275 [139662]
        automatically matched to d1jvfa_
        complexed with dcn, nad
      4. 686697Domain d2pd4d1: 2pd4 D:2-275 [139663]
        automatically matched to d1jvfa_
        complexed with dcn, nad
  3. 686702Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (11 PDB entries)
    1. Domains for 1nhg:
      1. 686709Domain d1nhg.1: 1nhg A:,C: [80516]
      2. 686710Domain d1nhg.2: 1nhg B:,D: [80517]
        complexed with nad, tcl
    2. Domains for 1nhw:
      1. 686711Domain d1nhw.1: 1nhw A:,C: [80518]
      2. 686712Domain d1nhw.2: 1nhw B:,D: [80519]
        complexed with nad, tcc
    3. Domains for 1nnu:
      1. 686717Domain d1nnu.1: 1nnu A:,C: [80672]
      2. 686718Domain d1nnu.2: 1nnu B:,D: [80673]
        complexed with nad, tct
    4. Domains for 1uh5:
      1. 686703Domain d1uh5a_: 1uh5 A: [107840]
      2. 686704Domain d1uh5b_: 1uh5 B: [107841]
        complexed with nad, tcl
    5. Domains for 1v35:
      1. 686715Domain d1v35a_: 1v35 A: [108301]
      2. 686716Domain d1v35b_: 1v35 B: [108302]
        complexed with nai
    6. Domains for 1vrw:
      1. 686713Domain d1vrwa1: 1vrw A:97-425 [120484]
        complexed with nad
      2. 686714Domain d1vrwb1: 1vrw B:97-425 [120485]
        automatically matched to 1VRW A:97-425
        complexed with nad
    7. Domains for 1zsn:
      1. 686719Domain d1zsna1: 1zsn A:97-425 [125608]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn2
      2. 686720Domain d1zsnb1: 1zsn B:97-425 [125609]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn2
    8. Domains for 1zw1:
      1. 686725Domain d1zw1a1: 1zw1 A:97-425 [125735]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn5
      2. 686726Domain d1zw1b1: 1zw1 B:97-425 [125736]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn5
    9. Domains for 1zxb:
      1. 686721Domain d1zxba1: 1zxb A:97-425 [125767]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn3
      2. 686722Domain d1zxbb1: 1zxb B:97-425 [125768]
        automatically matched to 1VRW A:97-425
        complexed with nad, tn3
    10. Domains for 1zxl:
      1. 686723Domain d1zxla1: 1zxl A:97-425 [125782]
        automatically matched to 1VRW A:97-425
        complexed with jp1, nad
      2. 686724Domain d1zxlb1: 1zxl B:97-425 [125783]
        automatically matched to 1VRW A:97-425
        complexed with jp1, nad
    11. Domains for 2o2y:
      1. 686705Domain d2o2ya1: 2o2y A:15-342 [138894]
        automatically matched to 1VRW A:97-425
        complexed with cl, nad, so4, tcl
      2. 686706Domain d2o2yb1: 2o2y B:15-342 [138895]
        automatically matched to 1VRW A:97-425
        complexed with cl, nad, so4, tcl
      3. 686707Domain d2o2yc1: 2o2y C:14-342 [138896]
        automatically matched to 1VRW A:97-425
        complexed with cl, nad, so4, tcl
      4. 686708Domain d2o2yd1: 2o2y D:15-342 [138897]
        automatically matched to 1VRW A:97-425
        complexed with cl, nad, so4, tcl
  4. 686727Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (19 PDB entries)
    1. Domains for 1bvr:
      1. 686762Domain d1bvra_: 1bvr A: [29913]
      2. 686763Domain d1bvrb_: 1bvr B: [29914]
      3. 686764Domain d1bvrc_: 1bvr C: [29915]
      4. 686765Domain d1bvrd_: 1bvr D: [29916]
      5. 686766Domain d1bvre_: 1bvr E: [29917]
      6. 686767Domain d1bvrf_: 1bvr F: [29918]
        complexed with nad, tht
    2. Domain for 1eny:
    3. Domain for 1enz:
    4. Domains for 1p44:
      1. 686741Domain d1p44a_: 1p44 A: [94076]
      2. 686742Domain d1p44b_: 1p44 B: [94077]
      3. 686743Domain d1p44c_: 1p44 C: [94078]
      4. 686744Domain d1p44d_: 1p44 D: [94079]
      5. 686745Domain d1p44e_: 1p44 E: [94080]
      6. 686746Domain d1p44f_: 1p44 F: [94081]
        complexed with geq, nad
    5. Domains for 1p45:
      1. 686754Domain d1p45a_: 1p45 A: [94082]
      2. 686755Domain d1p45b_: 1p45 B: [94083]
        complexed with nad, tcl
    6. Domain for 1zid:
    7. Domain for 2aq8:
    8. Domain for 2aqk:
    9. Domains for 2b35:
      1. 686748Domain d2b35a1: 2b35 A:2-269 [127767]
        automatically matched to d1bvra_
        complexed with nad, tcl
      2. 686749Domain d2b35b1: 2b35 B:2-269 [127768]
        automatically matched to d1bvra_
        complexed with nad, tcl
      3. 686750Domain d2b35c1: 2b35 C:2-269 [127769]
        automatically matched to d1bvra_
        complexed with nad, tcl
      4. 686751Domain d2b35d1: 2b35 D:2-269 [127770]
        automatically matched to d1bvra_
        complexed with nad, tcl
      5. 686752Domain d2b35e1: 2b35 E:2-269 [127771]
        automatically matched to d1bvra_
        complexed with nad, tcl
      6. 686753Domain d2b35f1: 2b35 F:2-269 [127772]
        automatically matched to d1bvra_
        complexed with nad, tcl
    10. Domains for 2b36:
      1. 686768Domain d2b36a1: 2b36 A:2-269 [127773]
        automatically matched to d1bvra_
        complexed with 5pp, nad
      2. 686769Domain d2b36b1: 2b36 B:2-269 [127774]
        automatically matched to d1bvra_
        complexed with 5pp, nad
      3. 686770Domain d2b36c1: 2b36 C:2-269 [127775]
        automatically matched to d1bvra_
        complexed with 5pp, nad
      4. 686771Domain d2b36d1: 2b36 D:2-269 [127776]
        automatically matched to d1bvra_
        complexed with 5pp, nad
      5. 686772Domain d2b36e1: 2b36 E:2-269 [127777]
        automatically matched to d1bvra_
        complexed with 5pp, nad
      6. 686773Domain d2b36f1: 2b36 F:2-269 [127778]
        automatically matched to d1bvra_
        complexed with 5pp, nad
    11. Domains for 2b37:
      1. 686756Domain d2b37a1: 2b37 A:2-269 [127779]
        automatically matched to d1bvra_
        complexed with 8ps, nad
      2. 686757Domain d2b37b1: 2b37 B:2-269 [127780]
        automatically matched to d1bvra_
        complexed with 8ps, nad
      3. 686758Domain d2b37c1: 2b37 C:2-269 [127781]
        automatically matched to d1bvra_
        complexed with 8ps, nad
      4. 686759Domain d2b37d1: 2b37 D:2-269 [127782]
        automatically matched to d1bvra_
        complexed with 8ps, nad
      5. 686760Domain d2b37e1: 2b37 E:2-269 [127783]
        automatically matched to d1bvra_
        complexed with 8ps, nad
      6. 686761Domain d2b37f1: 2b37 F:2-269 [127784]
        automatically matched to d1bvra_
        complexed with 8ps, nad
    12. Domain for 2h7i:
    13. Domain for 2h7l:
    14. Domain for 2h7m:
    15. Domain for 2h7n:
    16. Domain for 2h7p:
    17. Domain for 2h9i:
    18. Domains for 2ntj:
      1. 686736Domain d2ntja1: 2ntj A:3-269 [138581]
        automatically matched to d1bvra_
        complexed with p1h; mutant
      2. 686737Domain d2ntjb1: 2ntj B:3-269 [138582]
        automatically matched to d1bvra_
        complexed with p1h; mutant
    19. Domain for 2nv6:
  5. 686774Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    1. Domains for 1cwu:
      1. 686778Domain d1cwua_: 1cwu A: [29908]
      2. 686779Domain d1cwub_: 1cwu B: [29909]
        complexed with nad, tdb; mutant
    2. Domain for 1d7o:
    3. Domain for 1eno:
    4. Domain for 1enp:
  6. 686780Thermus thermophilus [TaxId:274] [117409] (2 PDB entries)
    1. Domains for 1ulu:
      1. 686781Domain d1ulua_: 1ulu A: [113292]
      2. 686782Domain d1ulub_: 1ulu B: [113293]
      3. 686783Domain d1uluc_: 1ulu C: [113294]
      4. 686784Domain d1ulud_: 1ulu D: [113295]
    2. Domains for 2yw9:
      1. 686785Domain d2yw9a1: 2yw9 A:1-256 [140087]
        automatically matched to d1ulud_
        complexed with nap
      2. 686786Domain d2yw9b1: 2yw9 B:1-256 [140088]
        automatically matched to d1ulud_
        complexed with nap
      3. 686787Domain d2yw9c1: 2yw9 C:1-256 [140089]
        automatically matched to d1ulud_
        complexed with nap
      4. 686788Domain d2yw9d1: 2yw9 D:1-256 [140090]
        automatically matched to d1ulud_
        complexed with nap
      5. 686789Domain d2yw9e1: 2yw9 E:1-256 [140091]
        automatically matched to d1ulud_
        complexed with nap
      6. 686790Domain d2yw9f1: 2yw9 F:1-256 [140092]
        automatically matched to d1ulud_
        complexed with nap
      7. 686791Domain d2yw9g1: 2yw9 G:1-256 [140093]
        automatically matched to d1ulud_
        complexed with nap
      8. 686792Domain d2yw9h1: 2yw9 H:1-256 [140094]
        automatically matched to d1ulud_
        complexed with nap

More info for Protein Enoyl-ACP reductase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Enoyl-ACP reductase from c.2.1.2: Tyrosine-dependent oxidoreductases: