SCOP 1.63: Protein: Human estrogenic 17beta-hydroxysteroid dehydrogenase

Lineage for Protein: Human estrogenic 17beta-hydroxysteroid dehydrogenase

Root: SCOP 1.63
Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (31 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51773] (11 PDB entries)
1. Domain for 1a27:
  - Domain d1a27__: 1a27 - [29839]
    complexed with est, nap; mutant
2. Domain for 1bhs:
  - Domain d1bhs__: 1bhs - [29840]
3. Domain for 1dht:
  - Domain d1dhta_: 1dht A: [29843]
    complexed with dht
4. Domains for 1equ:
  1. Domain d1equa_: 1equ A: [29846]
  2. Domain d1equb_: 1equ B: [29847]
    complexed with equ, ndp
5. Domain for 1fds:
  - Domain d1fds__: 1fds - [29838]
    complexed with est
6. Domain for 1fdt:
  - Domain d1fdt__: 1fdt - [29841]
    complexed with est, nap, so4
7. Domains for 1fdu:
  1. Domain d1fdua_: 1fdu A: [29848]
  2. Domain d1fdub_: 1fdu B: [29849]
  3. Domain d1fduc_: 1fdu C: [29850]
  4. Domain d1fdud_: 1fdu D: [29851]
    complexed with est, nap, so4; mutant
8. Domains for 1fdv:
  1. Domain d1fdva_: 1fdv A: [29852]
  2. Domain d1fdvb_: 1fdv B: [29853]
  3. Domain d1fdvc_: 1fdv C: [29854]
  4. Domain d1fdvd_: 1fdv D: [29855]
    complexed with nad, so4; mutant
9. Domain for 1fdw:
  - Domain d1fdw__: 1fdw - [29845]
    complexed with est; mutant
10. Domain for 1iol:
  - Domain d1iol__: 1iol - [29842]
    complexed with est
11. Domain for 3dhe:
  - Domain d3dhea_: 3dhe A: [29844]
    complexed with and

More info for Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.61
Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.65
Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08